CD1 lipidomes reveal lipid-binding motifs and size-based antigen-display mechanisms

• Published in: Cell Vol. 186; no. 21; pp. 4583 - 4596.e13
• Main Authors: Huang, Shouxiong, Shahine, Adam, Cheng, Tan-Yun, Chen, Yi-Ling, Ng, Soo Weei, Balaji, Gautham R., Farquhar, Rachel, Gras, Stephanie, Hardman, Clare S., Altman, John D., Tahiri, Nabil, Minnaard, Adriaan J., Ogg, Graham S., Mayfield, Jacob A., Rossjohn, Jamie, Moody, D. Branch
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.10.2023
• Subjects: Amino Acid Motifs; Antigen Presentation; antigen processing; Antigens, CD1 - chemistry; Antigens, CD1 - metabolism; CD1; dendritic cells; Humans; Lipidomics; Lipids - chemistry; major histocompatibility complex; sphingolipids; T cell receptor; T cells; T-Lymphocytes; CD1; dendritic cells; T cell receptor; antigen presentation; sphingolipids; major histocompatibility complex; antigen processing; T cells; lipidomics

The CD1 system binds lipid antigens for display to T cells. Here, we solved lipidomes for the four human CD1 antigen-presenting molecules, providing a map of self-lipid display. Answering a basic question, the detection of >2,000 CD1-lipid complexes demonstrates broad presentation of self-sphingo...