Chemical enhancement of percutaneous absorption in relation to stratum corneum structural alterations
The outermost layer of the skin, stratum corneum (SC), provides an outstanding barrier against the external environment and is also responsible for skin impermeability toward most solutes. The barrier function is related to the unique composition of the SC lipids and their complex structural arrange...
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Published in | Journal of controlled release Vol. 59; no. 2; pp. 149 - 161 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Amsterdam
Elsevier B.V
20.05.1999
Elsevier |
Subjects | |
Online Access | Get full text |
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Abstract | The outermost layer of the skin, stratum corneum (SC), provides an outstanding barrier against the external environment and is also responsible for skin impermeability toward most solutes. The barrier function is related to the unique composition of the SC lipids and their complex structural arrangement. The lipoidal matrix of the SC, therefore, is a target of penetration enhancer action. The literature on the skin barrier structure and function and on the mechanisms of action of some well established permeation promoters, with a focus on their impact on SC structural alterations, is reviewed. Data obtained from infrared, thermal, and fluorescence spectroscopic examinations of the SC and its components imply enhancer improved permeation of solutes through the SC is associated with alterations involving the hydrocarbon chains of the SC lipid components. Data obtained from electron microscopy and X-ray diffraction reveals that the disordering of the lamellar packing is also an important mechanism for increased permeation of drugs induced by penetration enhancers. |
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AbstractList | The outermost layer of the skin, stratum corneum (SC), provides an outstanding barrier against the external environment and is also responsible for skin impermeability toward most solutes. The barrier function is related to the unique composition of the SC lipids and their complex structural arrangement. The lipoidal matrix of the SC, therefore, is a target of penetration enhancer action. The literature on the skin barrier structure and function and on the mechanisms of action of some well established permeation promoters, with a focus on their impact on SC structural alterations, is reviewed. Data obtained from infrared, thermal, and fluorescence spectroscopic examinations of the SC and its components imply enhancer improved permeation of solutes through the SC is associated with alterations involving the hydrocarbon chains of the SC lipid components. Data obtained from electron microscopy and X-ray diffraction reveals that the disordering of the lamellar packing is also an important mechanism for increased permeation of drugs induced by penetration enhancers. |
Author | Urtti, Arto A. Bouwstra, Joke Marjukka Suhonen, T |
Author_xml | – sequence: 1 givenname: T surname: Marjukka Suhonen fullname: Marjukka Suhonen, T organization: Department of Pharmaceutics, University of Kuopio, Kuopio, Finland – sequence: 2 givenname: Joke surname: A. Bouwstra fullname: A. Bouwstra, Joke organization: LACDR Gorlaeus Laboratories, Leiden, The Netherlands – sequence: 3 givenname: Arto surname: Urtti fullname: Urtti, Arto organization: Department of Pharmaceutics, University of Kuopio, Kuopio, Finland |
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Keywords | Lipid layers Skin Stratum corneum Permeability Penetration enhancers Pharmaceutical technology Permeation Molecular interaction Lipids X ray diffraction Fluorescence spectrometry Infrared spectrometry Absorption Absorption enhancer Mechanism of action |
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SubjectTerms | Animals Biological and medical sciences Epidermis - anatomy & histology Epidermis - chemistry Ethanol - chemistry General pharmacology Humans Lipid layers Lipids - chemistry Medical sciences Penetration enhancers Permeability Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Proteins - metabolism Skin Skin Absorption - drug effects Spectrum Analysis Stratum corneum Water - chemistry |
Title | Chemical enhancement of percutaneous absorption in relation to stratum corneum structural alterations |
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