Chemical enhancement of percutaneous absorption in relation to stratum corneum structural alterations
The outermost layer of the skin, stratum corneum (SC), provides an outstanding barrier against the external environment and is also responsible for skin impermeability toward most solutes. The barrier function is related to the unique composition of the SC lipids and their complex structural arrange...
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| Published in | Journal of controlled release Vol. 59; no. 2; pp. 149 - 161 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
Elsevier B.V
20.05.1999
Elsevier |
| Subjects | |
| Online Access | Get full text |
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| Abstract | The outermost layer of the skin, stratum corneum (SC), provides an outstanding barrier against the external environment and is also responsible for skin impermeability toward most solutes. The barrier function is related to the unique composition of the SC lipids and their complex structural arrangement. The lipoidal matrix of the SC, therefore, is a target of penetration enhancer action. The literature on the skin barrier structure and function and on the mechanisms of action of some well established permeation promoters, with a focus on their impact on SC structural alterations, is reviewed. Data obtained from infrared, thermal, and fluorescence spectroscopic examinations of the SC and its components imply enhancer improved permeation of solutes through the SC is associated with alterations involving the hydrocarbon chains of the SC lipid components. Data obtained from electron microscopy and X-ray diffraction reveals that the disordering of the lamellar packing is also an important mechanism for increased permeation of drugs induced by penetration enhancers. |
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| AbstractList | The outermost layer of the skin, stratum corneum (SC), provides an outstanding barrier against the external environment and is also responsible for skin impermeability toward most solutes. The barrier function is related to the unique composition of the SC lipids and their complex structural arrangement. The lipoidal matrix of the SC, therefore, is a target of penetration enhancer action. The literature on the skin barrier structure and function and on the mechanisms of action of some well established permeation promoters, with a focus on their impact on SC structural alterations, is reviewed. Data obtained from infrared, thermal, and fluorescence spectroscopic examinations of the SC and its components imply enhancer improved permeation of solutes through the SC is associated with alterations involving the hydrocarbon chains of the SC lipid components. Data obtained from electron microscopy and X-ray diffraction reveals that the disordering of the lamellar packing is also an important mechanism for increased permeation of drugs induced by penetration enhancers. |
| Author | Urtti, Arto A. Bouwstra, Joke Marjukka Suhonen, T |
| Author_xml | – sequence: 1 givenname: T surname: Marjukka Suhonen fullname: Marjukka Suhonen, T organization: Department of Pharmaceutics, University of Kuopio, Kuopio, Finland – sequence: 2 givenname: Joke surname: A. Bouwstra fullname: A. Bouwstra, Joke organization: LACDR Gorlaeus Laboratories, Leiden, The Netherlands – sequence: 3 givenname: Arto surname: Urtti fullname: Urtti, Arto organization: Department of Pharmaceutics, University of Kuopio, Kuopio, Finland |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1796976$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/10332050$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/0168-3659(94)00105-4 10.1016/S0022-2275(20)42010-3 10.1016/0168-3659(85)90034-3 10.1023/A:1015921702258 10.1111/1523-1747.ep12492217 10.1172/JCI117352 10.1002/jps.2600760108 10.1016/0378-5173(86)90057-8 10.1016/0378-5173(92)90365-9 10.1001/archderm.118.7.474 10.1111/1523-1747.ep12328031 10.1016/S0006-3495(94)80629-0 10.1016/0009-3084(86)90069-1 10.1016/S0022-2275(20)40054-9 10.1016/S0021-9258(19)86027-1 10.1002/bip.1977.360161017 10.1016/0168-3659(87)90066-6 10.1016/0005-2760(94)90252-6 10.1111/1523-1747.ep12470197 10.1016/0378-5173(92)90105-B 10.1111/j.2042-7158.1979.tb13456.x 10.1023/A:1015960815578 10.1023/A:1018954420874 10.1016/0168-3659(91)90129-2 10.1111/1523-1747.ep12285373 10.1016/0005-2736(93)90171-U 10.1016/S0022-2275(20)37950-5 10.1016/0168-3659(91)90112-Q 10.1016/0005-2736(94)90040-X 10.1016/0168-3659(90)90184-U 10.1002/jps.2600800111 10.1073/pnas.90.22.10504 10.1111/j.2042-7158.1994.tb03248.x 10.1038/jid.1968.3 10.1016/0378-5173(94)90457-X 10.1111/1523-1747.ep12687968 10.1016/S0022-2275(20)38401-7 10.1016/0005-2736(95)00069-F 10.1023/A:1015873511692 10.1016/0378-5173(91)90274-R 10.1111/j.1365-2133.1994.tb08452.x 10.1111/1523-1747.ep12515931 10.1083/jcb.65.1.180 10.1016/S0022-2275(20)38005-6 10.1021/bi00410a031 10.1023/A:1015810312465 10.1023/A:1015879925147 10.1016/0168-3659(93)90068-G 10.1016/0168-3659(90)90123-B 10.1016/0378-5173(89)90356-6 10.1007/BF02431971 10.1016/0168-3659(90)90086-9 10.1021/bi00382a045 10.1023/A:1015980516564 10.1023/A:1015845632280 10.1016/0005-2736(92)90402-8 10.1001/archderm.129.6.728 10.1159/000211300 10.1016/0168-3659(91)90115-T 10.1023/A:1018953929457 10.3109/03639048309044701 10.1016/0378-5173(91)90297-2 10.1002/jps.2600730831 10.2340/00015555741214 10.1111/1523-1747.ep12291678 10.1111/1523-1747.ep12470233 10.1023/A:1018998529283 10.1016/0168-3659(91)90006-Y 10.1016/0168-3659(94)90008-6 10.1111/1523-1747.ep12531118 10.1016/0378-5173(91)90341-K 10.1152/physrev.1971.51.4.702 10.1111/1523-1747.ep12514716 10.1111/j.1365-2133.1969.tb16056.x 10.1016/0005-2736(93)90418-Y 10.1016/0005-2736(94)90024-8 10.1016/0168-3659(94)90179-1 10.1111/1523-1747.ep12475655 10.1023/A:1015822312426 10.1038/jid.1983.12 10.1016/S0378-5173(96)04726-6 10.1016/0168-3659(87)90063-0 10.1016/B978-0-12-024924-4.50006-7 10.1016/0378-5173(92)90158-X 10.1016/0378-5173(90)90145-T 10.1111/1523-1747.ep12393214 10.1016/0378-5173(88)90004-X |
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| Keywords | Lipid layers Skin Stratum corneum Permeability Penetration enhancers Pharmaceutical technology Permeation Molecular interaction Lipids X ray diffraction Fluorescence spectrometry Infrared spectrometry Absorption Absorption enhancer Mechanism of action |
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| References | Behl, Flynn, Kurihara, Harper, Smith, Higuchi, Ho, Pierson (BIB68) 1980; 75 Sweeney, Downing (BIB20) 1970; 55 H. Schaefer, T. Redelmeier, Skin barrier, Karger, 1996, pp. 87–117. M. Goodman, B.W. Barry, Action of penetration enhancers on human stratum corneum as assessed by differential scanning calorimetry, in: R.L. Bronaugh, H.I. Maibach (Eds.), Percutaneous Absorption: Mechanisms-Methodology-Drug Delivery, Marcel Dekker, New York, 1989, pp. 567–593. Kou, Roy, Du, Fujiki (BIB49) 1993; 10 Mak, Potts, Guy (BIB93) 1990; 7 Squier, Cox, Wertz (BIB21) 1991; 96 Golden, Guzek, Kennedy, McKie, Potts (BIB26) 1987; 26 Grubauer, Feingold, Harris, Elias (BIB17) 1989; 30 Bouwstra, Gooris, van der Spek, Lavrijsen, Bras (BIB37) 1994; 1212 Hueber, Schaefer, Wepierre (BIB47) 1994; 7 Williams, Elias (BIB33) 1987; 3 Ongpipattanakul, Burnette, Potts, Francoeur (BIB60) 1992; 19 Bouwstra, S, Cheng, Weerheim, Bras, Ponec (BIB46) 1996; 37 G.F. Odland, Structure of the skin, in: L.A. Goldsmith (Ed.), Biochemistry and physiology of the skin, Oxford University Press, New York, 1983, pp. 3–63. Bommannan, Potts, Guy (BIB74) 1991; 16 Schückler, Bouwstra, Gooris, Lee (BIB101) 1993; 23 Seki, Kawaguchi, Juni, Sugibayashi, Morimoto (BIB9) 1991; 17 Fenske, Thewalt, Bloom, Kitson (BIB41) 1994; 67 Wiechers, deZeeuw (BIB96) 1990; 6 Stoughton, McClure (BIB97) 1983; 9 Kurihara-Bergstrom, Knutson, DeNoble, Goates (BIB76) 1990; 7 Paige, Morse-Fisher, Harper (BIB23) 1994; 131 Lewis, Hadgraft (BIB99) 1990; 65 Oertel (BIB106) 1977; 16 Knutson, Potts, Guzek, Golden, McKie, Lambert, Higuchi (BIB56) 1985; 2 Elias (BIB50) 1983; 80 Schurer, Elias (BIB28) 1991; 24 Cornwell, Barry, Stoddart, Bouwstra (BIB40) 1994; 46 Engblom, Engström, Fontell (BIB45) 1995; 33 Goates, Knutson (BIB55) 1993; 1153 Rolland, Brzokewicz, Shroot, Jamoulle (BIB92) 1991; 76 Ghanem, Mahmoud, Higuchi, Liu, Good (BIB71) 1992; 78 Träuble (BIB57) 1971; 4 Aungst, Rogers, Shefter (BIB84) 1986; 33 Bouwstra, Gooris, Bras, Downing (BIB38) 1995; 36 G.L. Flynn, Mechanism of percutaneous absorption from physicochemical evidence, in: R.L. Bronaugh, H.I. Maibach (Eds.), Percutaneous Absorption: Mechanisms-Methodology-Drug Delivery, Marcel Dekker, New York, 1989, pp. 27–51. G.L. Flynn, Topical drug absorption and topical pharmaceutical systems, in: G.S. Banker, C.T. Rhodes (Eds.), Modem Pharmaceutics, Marcel Dekker, New York, 1990, pp. 263–325. Potts, Guy (BIB52) 1992; 9 Cooper (BIB86) 1984; 73 Inamori, Ghanem, Higuchi, Srinivasan (BIB81) 1994; 105 Francoeur, Golden, Potts (BIB62) 1990; 7 Forslind (BIB44) 1994; 74 Mak, Potts, Guy (BIB69) 1991; 8 Man, Feingold, Elias (BIB24) 1993; 129 B.W. Barry, Penetration enhancers. Mode of action in human skin, in: B. Shroot, H. Schaefer (Eds.), Pharmacology of the Skin, Karger, Basel, 1987, pp. 121–137. White, Mirejovsky, King (BIB39) 1988; 27 Imokawa, Yada, Higuchi, Okuda, Ohashi, Kawamata (BIB25) 1994; 94 Lampe, Burlingame, Whitney, Williams, Brown, Roitman, Elias (BIB18) 1983; 24 Klausner, Kleinfeld, Hoover, Karnovsky (BIB102) 1980; 255 Ongpipattanakul, Burnette, Potts, Francoeur (BIB61) 1991; 8 L.A. Goldsmith, Postranslational modification of proteins in keratinized tissue, in: L.A. Goldsmith (Ed.), The Biochemistry and Physiology of the Skin, Oxford University Press, New York, 1983, pp. 197–199. Ongpipattanakul, Francoeur, Potts (BIB43) 1994; 1190 Kobayashi, Matsuzawa, Sugibayashi, Morimoto, Kimura (BIB80) 1994; 11 Bouwstra, Gooris, van der Spek, Bras (BIB36) 1991; 97 U. Täuber, Drug metabolism in the skin: advantages and disadvantages, in: J. Hadgraft, R.H. Guy (Eds.), Transdermal Drug Delivery: Developmental Issues and Research Initiatives, Marcel Dekker, New York, 1989, pp. 99–112. Elias, Goerke, Friend (BIB31) 1977; 69 Boddé, Kruithof, Brussee, Koerten (BIB54) 1989; 253 Rolf (BIB5) 1988; 7 Krill, Knutson, Higuchi (BIB73) 1992; 112 Barry (BIB7) 1987; 6 Tsuzuki, Wong, Higuchi (BIB87) 1988; 46 Kim, Higuchi, Herron, Abraham (BIB72) 1993; 1148 L.A. Goldsmith, The epidermal cell periphery, in: L.A. Goldsmith (Ed.), The Biochemistry and Physiology of the Skin, Oxford University Press, New York, 1983, pp. 184–196. Goates, Knutson (BIB78) 1994; 1195 van Hal, Jeremiasse, Spies, Junginger, Bouwstra (BIB70) 1996; 106 Mak, Potts, Guy (BIB94) 1990; 12 Scheuplein, Blank (BIB2) 1971; 51 Bonina, Montenegro, De Capraris, Bousquet, Tirendi (BIB10) 1991; 77 Prausnitz, Bose, Langer, Weaver (BIB12) 1993; 90 Blank, Scheuplein (BIB1) 1969; 81 Peck, Ghanem, Higuchi (BIB82) 1994; 11 Singh, Maibach (BIB11) 1994; 11 J. Kost, D. Levy, R. Langer, Ultrasound as a transdermal enhancer, in: R.L. Bronaugh, H.I. Maibach (Eds.), Percutaneous absorption: mechanisms, methodology-drug delivery, Marcel Dekker, New York, 1989, pp. 595–601. Golden, Guzek, Harris, McKie, Potts (BIB65) 1986; 86 Knutson, Krill, Zhang (BIB75) 1990; 11 Alonso, Meirelles, Tabak (BIB67) 1995; 1237 Wertz, Downing (BIB29) 1983; 24 Garson, Doucet, Lévêque, Tsoucaris (BIB34) 1991; 96 Albery, Hadgraft (BIB51) 1979; 31 Guy, Hadgraft (BIB53) 1988; 5 Elias, Friend (BIB3) 1975; 65 P. Wertz, D. Downing, Epidermal lipids, in: L. Goldsmith (Ed.), Physiology, Biochemistry, and Molecular Biology of the Skin, Oxford University Press, New York, 1991, pp. 205–236. Aungst (BIB85) 1989; 6 Okamoto, Hashida, Sezaki (BIB89) 1991; 80 Potts, Francoeur (BIB19) 1991; 96 K.A. Walters, Penetration enhancers and their use in transdermal therapeutic systems, in: J. Hadgraft, R.H. Guy (Eds.), Transdermal Drug Delivery: Developmental Issues and Research Initiatives, Marcel Dekker, New York, 1989, pp. 197–246. Imokawa, Abe, Jin, Higaki, Kawashima, Hidano (BIB22) 1991; 96 Garrison, Doh, Potts, Abraham (BIB95) 1994; 31 Deamer, Bramhall (BIB58) 1986; 40 Kurihara-Bergstrom, Good (BIB103) 1987; 6 Goodman, Barry (BIB91) 1988; 91 Golden, McKie, Potts (BIB90) 1987; 76 Bouwstra, Gooris, Brussee, Salomons-de Vries, Bras (BIB100) 1992; 79 Hoogstraate, Verhoef, Brussee, IJzerman, Spies, Bodde (BIB88) 1991; 76 Stoughton (BIB98) 1982; 118 P.W. Wertz, D.T. Downing, Stratum corneum: biological and biochemical considerations, in: J. Hadgraft, R.H. Guy (Eds.), Transdermal Drug Delivery: Developmental Issues and Research Initiatives, Marcel Dekker, New York, 1989, pp. 1–22. Kai, Mak, Potts, Guy (BIB77) 1990; 12 Bouwstra, de Vries, Gooris, Bras, Brussee, Ponec (BIB64) 1991; 15 Elias, Leventhal (BIB32) 1979; 27 Bouwstra, Gooris, Salomons-de Vries, van der Spek, Bras (BIB35) 1992; 84 Oakeson, Goates, Knutson (BIB79) 1994; 28 Gay, Guy, Golden, Mak, Francoeur (BIB42) 1994; 103 Bouwstra, Salomons-de Vries, van den Bergh, Gooris (BIB83) 1996; 144 Matoltsy, Downes, Sweeney (BIB16) 1968; 50 Barry (BIB8) 1991; 15 Bommannan (10.1016/S0168-3659(98)00187-4_BIB74) 1991; 16 Blank (10.1016/S0168-3659(98)00187-4_BIB1) 1969; 81 Barry (10.1016/S0168-3659(98)00187-4_BIB7) 1987; 6 Forslind (10.1016/S0168-3659(98)00187-4_BIB44) 1994; 74 Williams (10.1016/S0168-3659(98)00187-4_BIB33) 1987; 3 10.1016/S0168-3659(98)00187-4_BIB63 Okamoto (10.1016/S0168-3659(98)00187-4_BIB89) 1991; 80 Elias (10.1016/S0168-3659(98)00187-4_BIB50) 1983; 80 Kurihara-Bergstrom (10.1016/S0168-3659(98)00187-4_BIB103) 1987; 6 10.1016/S0168-3659(98)00187-4_BIB66 Golden (10.1016/S0168-3659(98)00187-4_BIB90) 1987; 76 Cornwell (10.1016/S0168-3659(98)00187-4_BIB40) 1994; 46 Ongpipattanakul (10.1016/S0168-3659(98)00187-4_BIB60) 1992; 19 Bouwstra (10.1016/S0168-3659(98)00187-4_BIB37) 1994; 1212 Fenske (10.1016/S0168-3659(98)00187-4_BIB41) 1994; 67 Elias (10.1016/S0168-3659(98)00187-4_BIB3) 1975; 65 Grubauer (10.1016/S0168-3659(98)00187-4_BIB17) 1989; 30 Behl (10.1016/S0168-3659(98)00187-4_BIB68) 1980; 75 Bouwstra (10.1016/S0168-3659(98)00187-4_BIB100) 1992; 79 Kou (10.1016/S0168-3659(98)00187-4_BIB49) 1993; 10 Inamori (10.1016/S0168-3659(98)00187-4_BIB81) 1994; 105 Schückler (10.1016/S0168-3659(98)00187-4_BIB101) 1993; 23 Goates (10.1016/S0168-3659(98)00187-4_BIB78) 1994; 1195 Aungst (10.1016/S0168-3659(98)00187-4_BIB85) 1989; 6 Golden (10.1016/S0168-3659(98)00187-4_BIB65) 1986; 86 10.1016/S0168-3659(98)00187-4_BIB59 Oakeson (10.1016/S0168-3659(98)00187-4_BIB79) 1994; 28 Prausnitz (10.1016/S0168-3659(98)00187-4_BIB12) 1993; 90 Boddé (10.1016/S0168-3659(98)00187-4_BIB54) 1989; 253 Hoogstraate (10.1016/S0168-3659(98)00187-4_BIB88) 1991; 76 Imokawa (10.1016/S0168-3659(98)00187-4_BIB22) 1991; 96 van Hal (10.1016/S0168-3659(98)00187-4_BIB70) 1996; 106 Stoughton (10.1016/S0168-3659(98)00187-4_BIB97) 1983; 9 Paige (10.1016/S0168-3659(98)00187-4_BIB23) 1994; 131 10.1016/S0168-3659(98)00187-4_BIB4 10.1016/S0168-3659(98)00187-4_BIB6 Hueber (10.1016/S0168-3659(98)00187-4_BIB47) 1994; 7 Bouwstra (10.1016/S0168-3659(98)00187-4_BIB64) 1991; 15 Gay (10.1016/S0168-3659(98)00187-4_BIB42) 1994; 103 Imokawa (10.1016/S0168-3659(98)00187-4_BIB25) 1994; 94 Francoeur (10.1016/S0168-3659(98)00187-4_BIB62) 1990; 7 Ghanem (10.1016/S0168-3659(98)00187-4_BIB71) 1992; 78 Wiechers (10.1016/S0168-3659(98)00187-4_BIB96) 1990; 6 Knutson (10.1016/S0168-3659(98)00187-4_BIB56) 1985; 2 10.1016/S0168-3659(98)00187-4_BIB48 Krill (10.1016/S0168-3659(98)00187-4_BIB73) 1992; 112 Garson (10.1016/S0168-3659(98)00187-4_BIB34) 1991; 96 Bouwstra (10.1016/S0168-3659(98)00187-4_BIB38) 1995; 36 Scheuplein (10.1016/S0168-3659(98)00187-4_BIB2) 1971; 51 Bouwstra (10.1016/S0168-3659(98)00187-4_BIB35) 1992; 84 Peck (10.1016/S0168-3659(98)00187-4_BIB82) 1994; 11 10.1016/S0168-3659(98)00187-4_BIB30 Träuble (10.1016/S0168-3659(98)00187-4_BIB57) 1971; 4 Man (10.1016/S0168-3659(98)00187-4_BIB24) 1993; 129 Kurihara-Bergstrom (10.1016/S0168-3659(98)00187-4_BIB76) 1990; 7 Ongpipattanakul (10.1016/S0168-3659(98)00187-4_BIB43) 1994; 1190 Lampe (10.1016/S0168-3659(98)00187-4_BIB18) 1983; 24 Bouwstra (10.1016/S0168-3659(98)00187-4_BIB83) 1996; 144 Squier (10.1016/S0168-3659(98)00187-4_BIB21) 1991; 96 Deamer (10.1016/S0168-3659(98)00187-4_BIB58) 1986; 40 Mak (10.1016/S0168-3659(98)00187-4_BIB93) 1990; 7 Singh (10.1016/S0168-3659(98)00187-4_BIB11) 1994; 11 Kai (10.1016/S0168-3659(98)00187-4_BIB77) 1990; 12 Kobayashi (10.1016/S0168-3659(98)00187-4_BIB80) 1994; 11 Rolf (10.1016/S0168-3659(98)00187-4_BIB5) 1988; 7 Elias (10.1016/S0168-3659(98)00187-4_BIB32) 1979; 27 Barry (10.1016/S0168-3659(98)00187-4_BIB8) 1991; 15 10.1016/S0168-3659(98)00187-4_BIB27 Wertz (10.1016/S0168-3659(98)00187-4_BIB29) 1983; 24 Bouwstra (10.1016/S0168-3659(98)00187-4_BIB46) 1996; 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| References_xml | – volume: 81 start-page: 4 year: 1969 end-page: 10 ident: BIB1 article-title: Transport into and within the skin publication-title: Br. J. Dermatol. contributor: fullname: Scheuplein – volume: 24 start-page: 120 year: 1983 end-page: 130 ident: BIB18 article-title: Human stratum corneum lipids: characterization and regional variations publication-title: J. Lipid Res. contributor: fullname: Elias – volume: 7 start-page: 237 year: 1994 end-page: 244 ident: BIB47 article-title: Role of transepidermal and transfollicular routes in percutaneous absorption of steroids: in vitro studies on human skin publication-title: Skin Pharmacol. contributor: fullname: Wepierre – volume: 65 start-page: 211 year: 1990 end-page: 218 ident: BIB99 article-title: Mixed monolayers of dipalmitoylphopsphatidylcholine with Azone or oleic acid at the air–water interface publication-title: Int. J. Pharm. contributor: fullname: Hadgraft – volume: 80 start-page: 44s year: 1983 end-page: 49s ident: BIB50 article-title: Epidermal lipids, barrier function, and desquamation publication-title: J. Invest. Dermatol. contributor: fullname: Elias – volume: 12 start-page: 67 year: 1990 end-page: 75 ident: BIB94 article-title: Oleic acid concentration and effect in human stratum corneum: noninvasive determination by attenuated total reflectance infrared spectroscopy in vivo publication-title: J. Control. Rel. contributor: fullname: Guy – volume: 75 start-page: 346 year: 1980 end-page: 352 ident: BIB68 article-title: Hydration and percutaneous absorption: I. Influence of hydration on alkanol permeation through hairless mouse skin publication-title: J. Invest. Dermatol. contributor: fullname: Pierson – volume: 50 start-page: 19 year: 1968 end-page: 26 ident: BIB16 article-title: Studies of the epidermal water barrier. Part II. Investigation of the chemical nature of the water barrier publication-title: J. Invest. Dermatol. contributor: fullname: Sweeney – volume: 6 start-page: 87 year: 1990 end-page: 100 ident: BIB96 article-title: Transdermal drug delivery: efficacy and potential applications of the penetration enhancer Azone publication-title: Drug Design Deliv. contributor: fullname: deZeeuw – volume: 129 start-page: 728 year: 1993 end-page: 738 ident: BIB24 article-title: Exogenous lipids influence permeability barrier recovery in acetone-treated murine skin publication-title: Arch. Dermatol. contributor: fullname: Elias – volume: 84 start-page: 205 year: 1992 end-page: 216 ident: BIB35 article-title: Structure of human stratum corneum as a function of temperature and hydration: A wide-angle X-ray diffraction study publication-title: Int. J. Pharm. contributor: fullname: Bras – volume: 65 start-page: 180 year: 1975 end-page: 191 ident: BIB3 article-title: The permeability barrier in mammalian epidermis publication-title: J. Cell. Biol. contributor: fullname: Friend – volume: 6 start-page: 244 year: 1989 end-page: 247 ident: BIB85 article-title: Structure/effect studies of fatty acid isomers as skin penetration enhancers and skin irritants publication-title: Pharm. Res. contributor: fullname: Aungst – volume: 40 start-page: 167 year: 1986 end-page: 188 ident: BIB58 article-title: Permeability of lipid bilayers to water and ionic solutes publication-title: Chem. Phys. Lipids contributor: fullname: Bramhall – volume: 11 start-page: 93 year: 1990 end-page: 103 ident: BIB75 article-title: Solvent-mediated alterations of the stratum corneum publication-title: J. Control. Rel. contributor: fullname: Zhang – volume: 51 start-page: 702 year: 1971 end-page: 747 ident: BIB2 article-title: Permeability of the skin publication-title: Physiol. Rev. contributor: fullname: Blank – volume: 23 start-page: 27 year: 1993 end-page: 36 ident: BIB101 article-title: An X-ray diffraction study of some model stratum corneum lipids containing Azone and dodecyl- publication-title: J. Control. Rel. contributor: fullname: Lee – volume: 96 start-page: 523 year: 1991 end-page: 526 ident: BIB22 article-title: Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? publication-title: J. Invest. Dermatol. contributor: fullname: Hidano – volume: 16 start-page: 2329 year: 1977 end-page: 2345 ident: BIB106 article-title: Protein conformational changes induced in human stratum corneum by organic sulfoxides: an infrared spectroscopic investigation publication-title: Biopolymers contributor: fullname: Oertel – volume: 7 start-page: 762 year: 1990 end-page: 766 ident: BIB76 article-title: Percutaneous absorption enhancement of an ionic molecule by ethanol–water systems in human skin publication-title: Pharm. Res. contributor: fullname: Goates – volume: 11 start-page: 161 year: 1994 end-page: 213 ident: BIB11 article-title: Iontophoresis in drug delivery: basic principles and applications publication-title: Crit. Rev. Ther. Drug Carrier Syst. contributor: fullname: Maibach – volume: 1212 start-page: 183 year: 1994 end-page: 192 ident: BIB37 article-title: The lipid and protein structure of mouse stratum corneum: A wide and small angle diffraction study publication-title: Biochim. Biophys. Acta contributor: fullname: Bras – volume: 19 start-page: 143 year: 1992 end-page: 144 ident: BIB60 article-title: Solid phase behavior of lipids in porcine stratum corneum publication-title: Proc. Int. Symp. Control. Rel. Bioact. Mater. contributor: fullname: Francoeur – volume: 16 start-page: 299 year: 1991 end-page: 304 ident: BIB74 article-title: Examination of the effect of ethanol on human stratum corneum in vivo using infrared spectroscopy publication-title: J. Control. Rel. contributor: fullname: Guy – volume: 11 start-page: 1306 year: 1994 end-page: 1314 ident: BIB82 article-title: Hindered diffusion of polar molecules through and effective pore radii estimates of intact and ethanol treated human epidermal membrane publication-title: Pharm. Res. contributor: fullname: Higuchi – volume: 28 start-page: 277 year: 1994 end-page: 278 ident: BIB79 article-title: Selective extraction of stratum corneum components to probe mechanisms of enhanced percutaneous absorption publication-title: J. Control. Rel. contributor: fullname: Knutson – volume: 15 start-page: 237 year: 1991 end-page: 248 ident: BIB8 article-title: Lipid–protein-partitioning theory of skin penetration enhancement publication-title: J. Control. Rel. contributor: fullname: Barry – volume: 112 start-page: 273 year: 1992 end-page: 280 ident: BIB73 article-title: Ethanol effects on the stratum corneum lipid phase behavior publication-title: Biochim. Biophys. Acta contributor: fullname: Higuchi – volume: 46 start-page: 19 year: 1988 end-page: 23 ident: BIB87 article-title: Effect of primary alcohols on percutaneous absorption publication-title: Int. J. Pharm. contributor: fullname: Higuchi – volume: 96 start-page: 495 year: 1991 end-page: 499 ident: BIB19 article-title: The influence of stratum corneum morphology on water permeability publication-title: J. Invest. Dermatol. contributor: fullname: Francoeur – volume: 76 start-page: 217 year: 1991 end-page: 224 ident: BIB92 article-title: Effect of penetration enhancers on the phase transition of multilamellar liposomes of dipalmitoylphosphatidylcholine. A study by differential scanning calorimetry publication-title: Int. J. Pharm. contributor: fullname: Jamoulle – volume: 69 start-page: 535 year: 1977 end-page: 546 ident: BIB31 article-title: Mammalian epidermal barrier layer lipids: composition and influence on structure publication-title: J. Invest. Dermatol. contributor: fullname: Friend – volume: 131 start-page: 23 year: 1994 end-page: 27 ident: BIB23 article-title: Quantification of stratum corneum ceramides and lipid envelope ceramides in the hereditary ichthyoses publication-title: Br. J. Dermatol. contributor: fullname: Harper – volume: 253 start-page: 13 year: 1989 end-page: 24 ident: BIB54 article-title: Visualisation of normal and enhanced HgCI publication-title: Int. J. Pharm. contributor: fullname: Koerten – volume: 12 start-page: 103 year: 1990 end-page: 112 ident: BIB77 article-title: Mechanism of percutaneous penetration enhancement: effect of publication-title: J. Control. Rel. contributor: fullname: Guy – volume: 46 start-page: 938 year: 1994 end-page: 950 ident: BIB40 article-title: Wide-angle X-ray diffraction of human stratum corneum: effects of hydration and terpene enhancer treatment publication-title: J. Pharm. Pharmacol. contributor: fullname: Bouwstra – volume: 1190 start-page: 115 year: 1994 end-page: 122 ident: BIB43 article-title: Polymorphism in stratum corneum lipids publication-title: Biochim. Biophys. Acta contributor: fullname: Potts – volume: 1237 start-page: 6 year: 1995 end-page: 15 ident: BIB67 article-title: Effect of hydration upon the fluidity of intercellular membranes of stratum corneum: an EPR study publication-title: Biochim. Biophys. Acta contributor: fullname: Tabak – volume: 33 start-page: 225 year: 1986 end-page: 234 ident: BIB84 article-title: Enhancement of naloxone penetration through human skin in vitro using fatty acids, fatty alcohols, surfactants, sulfoxides and amides publication-title: Int. J. Pharm. contributor: fullname: Shefter – volume: 27 start-page: 525A year: 1979 ident: BIB32 article-title: Intercellular volume changes and cell surface area expansion during cornification publication-title: Clin. Res. contributor: fullname: Leventhal – volume: 7 start-page: 835 year: 1990 end-page: 841 ident: BIB93 article-title: Percutaneous penetration enhancement in vivo measured by attenuated total reflectance infrared spectroscopy publication-title: Pharm. Res. contributor: fullname: Guy – volume: 15 start-page: 209 year: 1991 end-page: 220 ident: BIB64 article-title: Thermodynamic and structural aspects of the skin barrier publication-title: J. Control. Rel. contributor: fullname: Ponec – volume: 31 start-page: 263 year: 1994 end-page: 269 ident: BIB95 article-title: Effect of oleic acid on human epidermis: fluorescence spectroscopic investigation publication-title: J. Control. Rel. contributor: fullname: Abraham – volume: 79 start-page: 141 year: 1992 end-page: 148 ident: BIB100 article-title: The influence of alkyl-azones on the ordering of the lamellae in human stratum corneum publication-title: Int. J. Pharm. contributor: fullname: Bras – volume: 67 start-page: 1562 year: 1994 end-page: 1573 ident: BIB41 article-title: Models of stratum corneum intercellular membranes: publication-title: Biophys. J. contributor: fullname: Kitson – volume: 76 start-page: 37 year: 1991 end-page: 47 ident: BIB88 article-title: Kinetics, ultrastructural aspects and molecular modelling of transdermal peptide flux enhancement by publication-title: Int. J. Pharm. contributor: fullname: Bodde – volume: 106 start-page: 89 year: 1996 end-page: 95 ident: BIB70 article-title: The structure of hydrated human stratum corneum by freeze fracture electron microscopy publication-title: I. Invest. Dermatol. contributor: fullname: Bouwstra – volume: 1148 start-page: 139 year: 1993 end-page: 151 ident: BIB72 article-title: Fluorescence anisotropy studies on the interaction of the short chain publication-title: Biochim. Biophys. Acta contributor: fullname: Abraham – volume: 96 start-page: 123 year: 1991 end-page: 126 ident: BIB21 article-title: Lipid content and water permeability of skin and oral mucosa publication-title: J. Invest. Dermatol. contributor: fullname: Wertz – volume: 3 start-page: 95 year: 1987 end-page: 122 ident: BIB33 article-title: The extracellular matrix of stratum corneum: Role of lipids in normal and pathological function publication-title: CRC Crit. Rev. Ther. Drug Carrier Syst. contributor: fullname: Elias – volume: 24 start-page: 759 year: 1983 end-page: 765 ident: BIB29 article-title: Ceramides of pig epidermis: structure determination publication-title: J. Lipid Res. contributor: fullname: Downing – volume: 9 start-page: 725 year: 1983 end-page: 744 ident: BIB97 article-title: Azone: A new non-toxic enhancer of cutaneous penetration publication-title: Drug Dev. Ind. Pharm. contributor: fullname: McClure – volume: 105 start-page: 113 year: 1994 end-page: 123 ident: BIB81 article-title: Macromolecular transport in and effective pore size of ethanol pretreated human epidermal membrane publication-title: Int. J. Pharm. contributor: fullname: Srinivasan – volume: 118 start-page: 474 year: 1982 end-page: 477 ident: BIB98 article-title: Enhanced percutaneous penetration with 1-dodecylazacycloheptan-2-one publication-title: Arch. Dermatol. contributor: fullname: Stoughton – volume: 55 start-page: 135 year: 1970 end-page: 140 ident: BIB20 article-title: The role of lipids in the epidermal barrier to water diffusion publication-title: J. Invest. Dermatol. contributor: fullname: Downing – volume: 86 start-page: 255 year: 1986 end-page: 259 ident: BIB65 article-title: Lipid thermotropic transitions in human stratum corneum publication-title: J. Invest. Dermatol. contributor: fullname: Potts – volume: 94 start-page: 89 year: 1994 end-page: 96 ident: BIB25 article-title: Pseudo-acylceramide with linoleic acid produces selective recovery of diminished cutaneous barrier function in essential fatty acid-deficient rats and has an inhibitory effect on epidermal hyperplasia publication-title: J. Clin. Invest. contributor: fullname: Kawamata – volume: 11 start-page: 96 year: 1994 end-page: 103 ident: BIB80 article-title: Analysis of the combined effect of 1-menthol and ethanol as skin permeation enhancers based on a two-layer skin model publication-title: Pharm. Res. contributor: fullname: Kimura – volume: 26 start-page: 2382 year: 1987 end-page: 2388 ident: BIB26 article-title: Stratum corneum lipid phase transitions and water barrier properties publication-title: Biochemistry contributor: fullname: Potts – volume: 2 start-page: 67 year: 1985 end-page: 87 ident: BIB56 article-title: Macro- and molecular physical–chemical considerations in understanding drug transport in the stratum corneum publication-title: J. Control. Rel. contributor: fullname: Higuchi – volume: 30 start-page: 89 year: 1989 end-page: 96 ident: BIB17 article-title: Lipid content and lipid type as determinants of the epidermal permeability barrier publication-title: J. Lipid Res. contributor: fullname: Elias – volume: 144 start-page: 81 year: 1996 end-page: 89 ident: BIB83 article-title: Changes in lipid organisation of the skin barrier by publication-title: Int. J. Pharm. contributor: fullname: Gooris – volume: 6 start-page: 85 year: 1987 end-page: 97 ident: BIB7 article-title: Mode of action of penetration enhancers in human skin publication-title: J. Control. Rel. contributor: fullname: Barry – volume: 91 start-page: 323 year: 1988 end-page: 327 ident: BIB91 article-title: Action of penetration enhancers on human skin as assessed by the permeation of model drugs 5-fluorouracil and estradiol. I. Infinite dose technique. publication-title: J. Invest. Dermatol. contributor: fullname: Barry – volume: 90 start-page: 10504 year: 1993 end-page: 10508 ident: BIB12 article-title: Electroporation of mammalian skin: A mechanism to enhance transdermal drug delivery publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Weaver – volume: 7 start-page: 130 year: 1988 end-page: 140 ident: BIB5 article-title: Chemical and physical methods of enhancing transdermal drug delivery publication-title: Pharm. Technol. contributor: fullname: Rolf – volume: 8 start-page: 1064 year: 1991 end-page: 1065 ident: BIB69 article-title: Does hydration affect intercellular lipid organization in the stratum corneum? publication-title: Pharm. Res. contributor: fullname: Guy – volume: 37 start-page: 999 year: 1996 end-page: 1011 ident: BIB46 article-title: Isolated SC lipids as a model for the skin barrier publication-title: J. Lipid Res. contributor: fullname: Ponec – volume: 77 start-page: 21 year: 1991 end-page: 29 ident: BIB10 article-title: 1-Alkylazacycloalkan-2-one esters as prodrugs of indomethacin for improved delivery through human skin publication-title: Int. J. Pharm. contributor: fullname: Tirendi – volume: 27 start-page: 3725 year: 1988 end-page: 3732 ident: BIB39 article-title: Structure of lamellar lipid domains and corneocyte envelopes of murine stratum corneum. An X-ray diffraction study publication-title: Biochemistry contributor: fullname: King – volume: 36 start-page: 685 year: 1995 end-page: 695 ident: BIB38 article-title: Lipid organization in pig stratum corneum publication-title: J. Lipid Res. contributor: fullname: Downing – volume: 33 start-page: 299 year: 1995 end-page: 305 ident: BIB45 article-title: The effect of the skin penetration enhancer Azone publication-title: J. Control. Rel. contributor: fullname: Fontell – volume: 4 start-page: 193 year: 1971 end-page: 208 ident: BIB57 article-title: The movement of molecules across lipid membranes: a molecular theory publication-title: J. Membr. Biol. contributor: fullname: Träuble – volume: 1153 start-page: 289 year: 1993 end-page: 298 ident: BIB55 article-title: Enhanced permeation and stratum corneum structural alterations in the presence of dithiothreitol publication-title: Biochim. Biophys. Acta contributor: fullname: Knutson – volume: 103 start-page: 233 year: 1994 end-page: 239 ident: BIB42 article-title: Characterization of low-temperature (i.e., <65°C) lipid transitions in human stratum corneum publication-title: J. Invest. Dermatol. contributor: fullname: Francoeur – volume: 76 start-page: 25 year: 1987 end-page: 28 ident: BIB90 article-title: Role of stratum corneum lipid fluidity in transdermal drug flux publication-title: J. Pharm. Sci. contributor: fullname: Potts – volume: 31 start-page: 140 year: 1979 end-page: 147 ident: BIB51 article-title: Percutaneous absorption: in vivo experiments publication-title: J. Pharm. Pharmacol. contributor: fullname: Hadgraft – volume: 5 start-page: 753 year: 1988 end-page: 758 ident: BIB53 article-title: Physicochemical aspects of percutaneous penetration and its enhancement publication-title: Pharm. Res. contributor: fullname: Hadgraft – volume: 1195 start-page: 169 year: 1994 end-page: 179 ident: BIB78 article-title: Enhanced permeation of polar compounds through human epidermis. I. Permeability and membrane structural changes in the presence of short chain alcohols publication-title: Biochim. Biophys. Acta contributor: fullname: Knutson – volume: 7 start-page: 621 year: 1990 end-page: 627 ident: BIB62 article-title: Oleic acid: its effects on stratum corneum in relation to (trans)dermal drug delivery publication-title: Pharm. Res. contributor: fullname: Potts – volume: 8 start-page: 350 year: 1991 end-page: 354 ident: BIB61 article-title: Evidence that oleic acid exists in a separate phase within stratum corneum lipids publication-title: Pharm. Res. contributor: fullname: Francoeur – volume: 97 start-page: 1005 year: 1991 end-page: 1012 ident: BIB36 article-title: Structural investigations of human stratum corneum by small-angle X-ray scattering publication-title: J. Invest. Dermatol. contributor: fullname: Bras – volume: 6 start-page: 51 year: 1987 end-page: 58 ident: BIB103 article-title: Skin development and permeability publication-title: J. Control. Rel. contributor: fullname: Good – volume: 24 start-page: 27 year: 1991 end-page: 56 ident: BIB28 article-title: The biochemistry and function of stratum corneum lipids publication-title: Adv. Lipid Res. contributor: fullname: Elias – volume: 17 start-page: 41 year: 1991 end-page: 48 ident: BIB9 article-title: Sustained transdermal delivery of zidovudine via controlled release of penetration enhancer publication-title: J. Control. Rel. contributor: fullname: Morimoto – volume: 74 start-page: 1 year: 1994 end-page: 6 ident: BIB44 article-title: A domain mosaic model of the skin barrier publication-title: Acta Derm. Venereol. contributor: fullname: Forslind – volume: 9 start-page: 663 year: 1992 end-page: 669 ident: BIB52 article-title: Predicting skin permeability publication-title: Pharm. Res. contributor: fullname: Guy – volume: 96 start-page: 43 year: 1991 end-page: 49 ident: BIB34 article-title: Oriented structure in human statum corneum revealed by X-ray diffraction publication-title: J. Invest. Dermatol. contributor: fullname: Tsoucaris – volume: 78 start-page: 137 year: 1992 end-page: 156 ident: BIB71 article-title: The effects of ethanol on the transport of lipophilic and polar permeants across hairless mouse skin: Methods/validation of a novel approach publication-title: Int. J. Pharm. contributor: fullname: Good – volume: 10 start-page: 986 year: 1993 end-page: 990 ident: BIB49 article-title: Effect of receiver fluid pH on publication-title: Pharm. Res. contributor: fullname: Fujiki – volume: 255 start-page: 1286 year: 1980 end-page: 1295 ident: BIB102 article-title: Lipid domains in membranes publication-title: J. Biol. Chem. contributor: fullname: Karnovsky – volume: 73 start-page: 1153 year: 1984 end-page: 1156 ident: BIB86 article-title: Increased skin permeability for lipophilic molecules publication-title: J. Pharm. Sci. contributor: fullname: Cooper – volume: 80 start-page: 39 year: 1991 end-page: 45 ident: BIB89 article-title: Effect of 1-alkyl- or 1-alkenylazacycloalkanone derivatives on the penetration of drugs with different lipophilicities through guinea pig skin publication-title: J. Pharm. Sci. contributor: fullname: Sezaki – volume: 33 start-page: 299 year: 1995 ident: 10.1016/S0168-3659(98)00187-4_BIB45 article-title: The effect of the skin penetration enhancer Azone® on fatty acid-sodium soap-water mixtures publication-title: J. Control. Rel. doi: 10.1016/0168-3659(94)00105-4 contributor: fullname: Engblom – volume: 37 start-page: 999 year: 1996 ident: 10.1016/S0168-3659(98)00187-4_BIB46 article-title: Isolated SC lipids as a model for the skin barrier publication-title: J. Lipid Res. doi: 10.1016/S0022-2275(20)42010-3 contributor: fullname: Bouwstra – volume: 2 start-page: 67 year: 1985 ident: 10.1016/S0168-3659(98)00187-4_BIB56 article-title: Macro- and molecular physical–chemical considerations in understanding drug transport in the stratum corneum publication-title: J. Control. Rel. doi: 10.1016/0168-3659(85)90034-3 contributor: fullname: Knutson – volume: 6 start-page: 87 year: 1990 ident: 10.1016/S0168-3659(98)00187-4_BIB96 article-title: Transdermal drug delivery: efficacy and potential applications of the penetration enhancer Azone publication-title: Drug Design Deliv. contributor: fullname: Wiechers – volume: 6 start-page: 244 year: 1989 ident: 10.1016/S0168-3659(98)00187-4_BIB85 article-title: Structure/effect studies of fatty acid isomers as skin penetration enhancers and skin irritants publication-title: Pharm. Res. doi: 10.1023/A:1015921702258 contributor: fullname: Aungst – volume: 97 start-page: 1005 year: 1991 ident: 10.1016/S0168-3659(98)00187-4_BIB36 article-title: Structural investigations of human stratum corneum by small-angle X-ray scattering publication-title: J. Invest. Dermatol. doi: 10.1111/1523-1747.ep12492217 contributor: fullname: Bouwstra – volume: 94 start-page: 89 year: 1994 ident: 10.1016/S0168-3659(98)00187-4_BIB25 article-title: Pseudo-acylceramide with linoleic acid produces selective recovery of diminished cutaneous barrier function in essential fatty acid-deficient rats and has an inhibitory effect on epidermal hyperplasia publication-title: J. Clin. Invest. doi: 10.1172/JCI117352 contributor: fullname: Imokawa – volume: 76 start-page: 25 year: 1987 ident: 10.1016/S0168-3659(98)00187-4_BIB90 article-title: Role of stratum corneum lipid fluidity in transdermal drug flux publication-title: J. Pharm. Sci. doi: 10.1002/jps.2600760108 contributor: fullname: Golden – volume: 33 start-page: 225 year: 1986 ident: 10.1016/S0168-3659(98)00187-4_BIB84 article-title: Enhancement of naloxone penetration through human skin in vitro using fatty acids, fatty alcohols, surfactants, sulfoxides and amides publication-title: Int. J. Pharm. doi: 10.1016/0378-5173(86)90057-8 contributor: fullname: Aungst – volume: 78 start-page: 137 year: 1992 ident: 10.1016/S0168-3659(98)00187-4_BIB71 article-title: The effects of ethanol on the transport of lipophilic and polar permeants across hairless mouse skin: Methods/validation of a novel approach publication-title: Int. J. Pharm. doi: 10.1016/0378-5173(92)90365-9 contributor: fullname: Ghanem – volume: 118 start-page: 474 year: 1982 ident: 10.1016/S0168-3659(98)00187-4_BIB98 article-title: Enhanced percutaneous penetration with 1-dodecylazacycloheptan-2-one publication-title: Arch. Dermatol. doi: 10.1001/archderm.118.7.474 contributor: fullname: Stoughton – volume: 106 start-page: 89 year: 1996 ident: 10.1016/S0168-3659(98)00187-4_BIB70 article-title: The structure of hydrated human stratum corneum by freeze fracture electron microscopy publication-title: I. Invest. Dermatol. doi: 10.1111/1523-1747.ep12328031 contributor: fullname: van Hal – volume: 67 start-page: 1562 year: 1994 ident: 10.1016/S0168-3659(98)00187-4_BIB41 article-title: Models of stratum corneum intercellular membranes: 3H NMR of macroscopically oriented multilayers publication-title: Biophys. J. doi: 10.1016/S0006-3495(94)80629-0 contributor: fullname: Fenske – volume: 7 start-page: 130 year: 1988 ident: 10.1016/S0168-3659(98)00187-4_BIB5 article-title: Chemical and physical methods of enhancing transdermal drug delivery publication-title: Pharm. Technol. contributor: fullname: Rolf – volume: 40 start-page: 167 year: 1986 ident: 10.1016/S0168-3659(98)00187-4_BIB58 article-title: Permeability of lipid bilayers to water and ionic solutes publication-title: Chem. Phys. Lipids doi: 10.1016/0009-3084(86)90069-1 contributor: fullname: Deamer – volume: 36 start-page: 685 year: 1995 ident: 10.1016/S0168-3659(98)00187-4_BIB38 article-title: Lipid organization in pig stratum corneum publication-title: J. Lipid Res. doi: 10.1016/S0022-2275(20)40054-9 contributor: fullname: Bouwstra – ident: 10.1016/S0168-3659(98)00187-4_BIB4 – volume: 255 start-page: 1286 year: 1980 ident: 10.1016/S0168-3659(98)00187-4_BIB102 article-title: Lipid domains in membranes publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)86027-1 contributor: fullname: Klausner – volume: 16 start-page: 2329 year: 1977 ident: 10.1016/S0168-3659(98)00187-4_BIB106 article-title: Protein conformational changes induced in human stratum corneum by organic sulfoxides: an infrared spectroscopic investigation publication-title: Biopolymers doi: 10.1002/bip.1977.360161017 contributor: fullname: Oertel – volume: 6 start-page: 85 year: 1987 ident: 10.1016/S0168-3659(98)00187-4_BIB7 article-title: Mode of action of penetration enhancers in human skin publication-title: J. Control. Rel. doi: 10.1016/0168-3659(87)90066-6 contributor: fullname: Barry – volume: 1212 start-page: 183 year: 1994 ident: 10.1016/S0168-3659(98)00187-4_BIB37 article-title: The lipid and protein structure of mouse stratum corneum: A wide and small angle diffraction study publication-title: Biochim. Biophys. Acta doi: 10.1016/0005-2760(94)90252-6 contributor: fullname: Bouwstra – volume: 96 start-page: 495 year: 1991 ident: 10.1016/S0168-3659(98)00187-4_BIB19 article-title: The influence of stratum corneum morphology on water permeability publication-title: J. Invest. Dermatol. doi: 10.1111/1523-1747.ep12470197 contributor: fullname: Potts – volume: 79 start-page: 141 year: 1992 ident: 10.1016/S0168-3659(98)00187-4_BIB100 article-title: The influence of alkyl-azones on the ordering of the lamellae in human stratum corneum publication-title: Int. J. Pharm. doi: 10.1016/0378-5173(92)90105-B contributor: fullname: Bouwstra – volume: 31 start-page: 140 year: 1979 ident: 10.1016/S0168-3659(98)00187-4_BIB51 article-title: Percutaneous absorption: in vivo experiments publication-title: J. Pharm. Pharmacol. doi: 10.1111/j.2042-7158.1979.tb13456.x contributor: fullname: Albery – volume: 7 start-page: 835 year: 1990 ident: 10.1016/S0168-3659(98)00187-4_BIB93 article-title: Percutaneous penetration enhancement in vivo measured by attenuated total reflectance infrared spectroscopy publication-title: Pharm. Res. doi: 10.1023/A:1015960815578 contributor: fullname: Mak – volume: 27 start-page: 525A year: 1979 ident: 10.1016/S0168-3659(98)00187-4_BIB32 article-title: Intercellular volume changes and cell surface area expansion during cornification publication-title: Clin. Res. contributor: fullname: Elias – volume: 10 start-page: 986 year: 1993 ident: 10.1016/S0168-3659(98)00187-4_BIB49 article-title: Effect of receiver fluid pH on in vitro skin flux of weakly ionizable drugs publication-title: Pharm. Res. doi: 10.1023/A:1018954420874 contributor: fullname: Kou – ident: 10.1016/S0168-3659(98)00187-4_BIB14 – volume: 17 start-page: 41 year: 1991 ident: 10.1016/S0168-3659(98)00187-4_BIB9 article-title: Sustained transdermal delivery of zidovudine via controlled release of penetration enhancer publication-title: J. Control. Rel. doi: 10.1016/0168-3659(91)90129-2 contributor: fullname: Seki – volume: 86 start-page: 255 year: 1986 ident: 10.1016/S0168-3659(98)00187-4_BIB65 article-title: Lipid thermotropic transitions in human stratum corneum publication-title: J. Invest. Dermatol. doi: 10.1111/1523-1747.ep12285373 contributor: fullname: Golden – volume: 1148 start-page: 139 year: 1993 ident: 10.1016/S0168-3659(98)00187-4_BIB72 article-title: Fluorescence anisotropy studies on the interaction of the short chain n-alkanols with stratum corneum lipid liposomes (SCLL) and distearoylphosphatidylcholine (DSPC)/distearoylphosphatidic acid (DSPA) liposomes publication-title: Biochim. Biophys. Acta doi: 10.1016/0005-2736(93)90171-U contributor: fullname: Kim – volume: 24 start-page: 759 year: 1983 ident: 10.1016/S0168-3659(98)00187-4_BIB29 article-title: Ceramides of pig epidermis: structure determination publication-title: J. Lipid Res. doi: 10.1016/S0022-2275(20)37950-5 contributor: fullname: Wertz – volume: 15 start-page: 209 year: 1991 ident: 10.1016/S0168-3659(98)00187-4_BIB64 article-title: Thermodynamic and structural aspects of the skin barrier publication-title: J. Control. Rel. doi: 10.1016/0168-3659(91)90112-Q contributor: fullname: Bouwstra – volume: 1190 start-page: 115 year: 1994 ident: 10.1016/S0168-3659(98)00187-4_BIB43 article-title: Polymorphism in stratum corneum lipids publication-title: Biochim. Biophys. Acta doi: 10.1016/0005-2736(94)90040-X contributor: fullname: Ongpipattanakul – volume: 12 start-page: 67 year: 1990 ident: 10.1016/S0168-3659(98)00187-4_BIB94 article-title: Oleic acid concentration and effect in human stratum corneum: noninvasive determination by attenuated total reflectance infrared spectroscopy in vivo publication-title: J. Control. Rel. doi: 10.1016/0168-3659(90)90184-U contributor: fullname: Mak – volume: 80 start-page: 39 year: 1991 ident: 10.1016/S0168-3659(98)00187-4_BIB89 article-title: Effect of 1-alkyl- or 1-alkenylazacycloalkanone derivatives on the penetration of drugs with different lipophilicities through guinea pig skin publication-title: J. Pharm. Sci. doi: 10.1002/jps.2600800111 contributor: fullname: Okamoto – volume: 90 start-page: 10504 year: 1993 ident: 10.1016/S0168-3659(98)00187-4_BIB12 article-title: Electroporation of mammalian skin: A mechanism to enhance transdermal drug delivery publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.90.22.10504 contributor: fullname: Prausnitz – volume: 46 start-page: 938 year: 1994 ident: 10.1016/S0168-3659(98)00187-4_BIB40 article-title: Wide-angle X-ray diffraction of human stratum corneum: effects of hydration and terpene enhancer treatment publication-title: J. Pharm. Pharmacol. doi: 10.1111/j.2042-7158.1994.tb03248.x contributor: fullname: Cornwell – volume: 50 start-page: 19 year: 1968 ident: 10.1016/S0168-3659(98)00187-4_BIB16 article-title: Studies of the epidermal water barrier. Part II. Investigation of the chemical nature of the water barrier publication-title: J. Invest. Dermatol. doi: 10.1038/jid.1968.3 contributor: fullname: Matoltsy – volume: 105 start-page: 113 year: 1994 ident: 10.1016/S0168-3659(98)00187-4_BIB81 article-title: Macromolecular transport in and effective pore size of ethanol pretreated human epidermal membrane publication-title: Int. J. Pharm. doi: 10.1016/0378-5173(94)90457-X contributor: fullname: Inamori – ident: 10.1016/S0168-3659(98)00187-4_BIB48 – volume: 69 start-page: 535 year: 1977 ident: 10.1016/S0168-3659(98)00187-4_BIB31 article-title: Mammalian epidermal barrier layer lipids: composition and influence on structure publication-title: J. Invest. Dermatol. doi: 10.1111/1523-1747.ep12687968 contributor: fullname: Elias – volume: 30 start-page: 89 year: 1989 ident: 10.1016/S0168-3659(98)00187-4_BIB17 article-title: Lipid content and lipid type as determinants of the epidermal permeability barrier publication-title: J. Lipid Res. doi: 10.1016/S0022-2275(20)38401-7 contributor: fullname: Grubauer – volume: 1237 start-page: 6 year: 1995 ident: 10.1016/S0168-3659(98)00187-4_BIB67 article-title: Effect of hydration upon the fluidity of intercellular membranes of stratum corneum: an EPR study publication-title: Biochim. Biophys. Acta doi: 10.1016/0005-2736(95)00069-F contributor: fullname: Alonso – ident: 10.1016/S0168-3659(98)00187-4_BIB105 – ident: 10.1016/S0168-3659(98)00187-4_BIB59 – volume: 8 start-page: 1064 year: 1991 ident: 10.1016/S0168-3659(98)00187-4_BIB69 article-title: Does hydration affect intercellular lipid organization in the stratum corneum? publication-title: Pharm. Res. doi: 10.1023/A:1015873511692 contributor: fullname: Mak – volume: 76 start-page: 217 year: 1991 ident: 10.1016/S0168-3659(98)00187-4_BIB92 article-title: Effect of penetration enhancers on the phase transition of multilamellar liposomes of dipalmitoylphosphatidylcholine. A study by differential scanning calorimetry publication-title: Int. J. Pharm. doi: 10.1016/0378-5173(91)90274-R contributor: fullname: Rolland – volume: 131 start-page: 23 year: 1994 ident: 10.1016/S0168-3659(98)00187-4_BIB23 article-title: Quantification of stratum corneum ceramides and lipid envelope ceramides in the hereditary ichthyoses publication-title: Br. J. Dermatol. doi: 10.1111/j.1365-2133.1994.tb08452.x contributor: fullname: Paige – volume: 96 start-page: 123 year: 1991 ident: 10.1016/S0168-3659(98)00187-4_BIB21 article-title: Lipid content and water permeability of skin and oral mucosa publication-title: J. Invest. Dermatol. doi: 10.1111/1523-1747.ep12515931 contributor: fullname: Squier – volume: 3 start-page: 95 year: 1987 ident: 10.1016/S0168-3659(98)00187-4_BIB33 article-title: The extracellular matrix of stratum corneum: Role of lipids in normal and pathological function publication-title: CRC Crit. Rev. Ther. Drug Carrier Syst. contributor: fullname: Williams – ident: 10.1016/S0168-3659(98)00187-4_BIB6 – volume: 65 start-page: 180 year: 1975 ident: 10.1016/S0168-3659(98)00187-4_BIB3 article-title: The permeability barrier in mammalian epidermis publication-title: J. Cell. Biol. doi: 10.1083/jcb.65.1.180 contributor: fullname: Elias – volume: 24 start-page: 120 year: 1983 ident: 10.1016/S0168-3659(98)00187-4_BIB18 article-title: Human stratum corneum lipids: characterization and regional variations publication-title: J. Lipid Res. doi: 10.1016/S0022-2275(20)38005-6 contributor: fullname: Lampe – ident: 10.1016/S0168-3659(98)00187-4_BIB104 – volume: 27 start-page: 3725 year: 1988 ident: 10.1016/S0168-3659(98)00187-4_BIB39 article-title: Structure of lamellar lipid domains and corneocyte envelopes of murine stratum corneum. An X-ray diffraction study publication-title: Biochemistry doi: 10.1021/bi00410a031 contributor: fullname: White – volume: 9 start-page: 663 year: 1992 ident: 10.1016/S0168-3659(98)00187-4_BIB52 article-title: Predicting skin permeability publication-title: Pharm. Res. doi: 10.1023/A:1015810312465 contributor: fullname: Potts – volume: 7 start-page: 762 year: 1990 ident: 10.1016/S0168-3659(98)00187-4_BIB76 article-title: Percutaneous absorption enhancement of an ionic molecule by ethanol–water systems in human skin publication-title: Pharm. Res. doi: 10.1023/A:1015879925147 contributor: fullname: Kurihara-Bergstrom – volume: 23 start-page: 27 year: 1993 ident: 10.1016/S0168-3659(98)00187-4_BIB101 article-title: An X-ray diffraction study of some model stratum corneum lipids containing Azone and dodecyl-L-pyroglutamate publication-title: J. Control. Rel. doi: 10.1016/0168-3659(93)90068-G contributor: fullname: Schückler – volume: 11 start-page: 93 year: 1990 ident: 10.1016/S0168-3659(98)00187-4_BIB75 article-title: Solvent-mediated alterations of the stratum corneum publication-title: J. Control. Rel. doi: 10.1016/0168-3659(90)90123-B contributor: fullname: Knutson – volume: 253 start-page: 13 year: 1989 ident: 10.1016/S0168-3659(98)00187-4_BIB54 article-title: Visualisation of normal and enhanced HgCI2 transport through human skin in vitro publication-title: Int. J. Pharm. doi: 10.1016/0378-5173(89)90356-6 contributor: fullname: Boddé – volume: 4 start-page: 193 year: 1971 ident: 10.1016/S0168-3659(98)00187-4_BIB57 article-title: The movement of molecules across lipid membranes: a molecular theory publication-title: J. Membr. Biol. doi: 10.1007/BF02431971 contributor: fullname: Träuble – volume: 12 start-page: 103 year: 1990 ident: 10.1016/S0168-3659(98)00187-4_BIB77 article-title: Mechanism of percutaneous penetration enhancement: effect of n-alkanols on the permeability barrier of hairless mouse skin publication-title: J. Control. Rel. doi: 10.1016/0168-3659(90)90086-9 contributor: fullname: Kai – ident: 10.1016/S0168-3659(98)00187-4_BIB63 doi: 10.1016/0168-3659(87)90066-6 – volume: 26 start-page: 2382 year: 1987 ident: 10.1016/S0168-3659(98)00187-4_BIB26 article-title: Stratum corneum lipid phase transitions and water barrier properties publication-title: Biochemistry doi: 10.1021/bi00382a045 contributor: fullname: Golden – volume: 5 start-page: 753 year: 1988 ident: 10.1016/S0168-3659(98)00187-4_BIB53 article-title: Physicochemical aspects of percutaneous penetration and its enhancement publication-title: Pharm. Res. doi: 10.1023/A:1015980516564 contributor: fullname: Guy – volume: 8 start-page: 350 year: 1991 ident: 10.1016/S0168-3659(98)00187-4_BIB61 article-title: Evidence that oleic acid exists in a separate phase within stratum corneum lipids publication-title: Pharm. Res. doi: 10.1023/A:1015845632280 contributor: fullname: Ongpipattanakul – ident: 10.1016/S0168-3659(98)00187-4_BIB15 – volume: 112 start-page: 273 year: 1992 ident: 10.1016/S0168-3659(98)00187-4_BIB73 article-title: Ethanol effects on the stratum corneum lipid phase behavior publication-title: Biochim. Biophys. Acta doi: 10.1016/0005-2736(92)90402-8 contributor: fullname: Krill – volume: 129 start-page: 728 year: 1993 ident: 10.1016/S0168-3659(98)00187-4_BIB24 article-title: Exogenous lipids influence permeability barrier recovery in acetone-treated murine skin publication-title: Arch. Dermatol. doi: 10.1001/archderm.129.6.728 contributor: fullname: Man – volume: 7 start-page: 237 year: 1994 ident: 10.1016/S0168-3659(98)00187-4_BIB47 article-title: Role of transepidermal and transfollicular routes in percutaneous absorption of steroids: in vitro studies on human skin publication-title: Skin Pharmacol. doi: 10.1159/000211300 contributor: fullname: Hueber – volume: 15 start-page: 237 year: 1991 ident: 10.1016/S0168-3659(98)00187-4_BIB8 article-title: Lipid–protein-partitioning theory of skin penetration enhancement publication-title: J. Control. Rel. doi: 10.1016/0168-3659(91)90115-T contributor: fullname: Barry – volume: 11 start-page: 96 year: 1994 ident: 10.1016/S0168-3659(98)00187-4_BIB80 article-title: Analysis of the combined effect of 1-menthol and ethanol as skin permeation enhancers based on a two-layer skin model publication-title: Pharm. Res. doi: 10.1023/A:1018953929457 contributor: fullname: Kobayashi – volume: 11 start-page: 161 year: 1994 ident: 10.1016/S0168-3659(98)00187-4_BIB11 article-title: Iontophoresis in drug delivery: basic principles and applications publication-title: Crit. Rev. Ther. Drug Carrier Syst. contributor: fullname: Singh – volume: 9 start-page: 725 year: 1983 ident: 10.1016/S0168-3659(98)00187-4_BIB97 article-title: Azone: A new non-toxic enhancer of cutaneous penetration publication-title: Drug Dev. Ind. Pharm. doi: 10.3109/03639048309044701 contributor: fullname: Stoughton – volume: 77 start-page: 21 year: 1991 ident: 10.1016/S0168-3659(98)00187-4_BIB10 article-title: 1-Alkylazacycloalkan-2-one esters as prodrugs of indomethacin for improved delivery through human skin publication-title: Int. J. Pharm. doi: 10.1016/0378-5173(91)90297-2 contributor: fullname: Bonina – volume: 73 start-page: 1153 year: 1984 ident: 10.1016/S0168-3659(98)00187-4_BIB86 article-title: Increased skin permeability for lipophilic molecules publication-title: J. Pharm. Sci. doi: 10.1002/jps.2600730831 contributor: fullname: Cooper – volume: 74 start-page: 1 year: 1994 ident: 10.1016/S0168-3659(98)00187-4_BIB44 article-title: A domain mosaic model of the skin barrier publication-title: Acta Derm. Venereol. doi: 10.2340/00015555741214 contributor: fullname: Forslind – volume: 55 start-page: 135 year: 1970 ident: 10.1016/S0168-3659(98)00187-4_BIB20 article-title: The role of lipids in the epidermal barrier to water diffusion publication-title: J. Invest. Dermatol. doi: 10.1111/1523-1747.ep12291678 contributor: fullname: Sweeney – volume: 96 start-page: 523 year: 1991 ident: 10.1016/S0168-3659(98)00187-4_BIB22 article-title: Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? publication-title: J. Invest. Dermatol. doi: 10.1111/1523-1747.ep12470233 contributor: fullname: Imokawa – volume: 11 start-page: 1306 year: 1994 ident: 10.1016/S0168-3659(98)00187-4_BIB82 article-title: Hindered diffusion of polar molecules through and effective pore radii estimates of intact and ethanol treated human epidermal membrane publication-title: Pharm. Res. doi: 10.1023/A:1018998529283 contributor: fullname: Peck – volume: 16 start-page: 299 year: 1991 ident: 10.1016/S0168-3659(98)00187-4_BIB74 article-title: Examination of the effect of ethanol on human stratum corneum in vivo using infrared spectroscopy publication-title: J. Control. Rel. doi: 10.1016/0168-3659(91)90006-Y contributor: fullname: Bommannan – volume: 31 start-page: 263 year: 1994 ident: 10.1016/S0168-3659(98)00187-4_BIB95 article-title: Effect of oleic acid on human epidermis: fluorescence spectroscopic investigation publication-title: J. Control. Rel. doi: 10.1016/0168-3659(94)90008-6 contributor: fullname: Garrison – ident: 10.1016/S0168-3659(98)00187-4_BIB66 – ident: 10.1016/S0168-3659(98)00187-4_BIB30 – volume: 75 start-page: 346 year: 1980 ident: 10.1016/S0168-3659(98)00187-4_BIB68 article-title: Hydration and percutaneous absorption: I. Influence of hydration on alkanol permeation through hairless mouse skin publication-title: J. Invest. Dermatol. doi: 10.1111/1523-1747.ep12531118 contributor: fullname: Behl – volume: 76 start-page: 37 year: 1991 ident: 10.1016/S0168-3659(98)00187-4_BIB88 article-title: Kinetics, ultrastructural aspects and molecular modelling of transdermal peptide flux enhancement by Nalkylazacycloheptanones publication-title: Int. J. Pharm. doi: 10.1016/0378-5173(91)90341-K contributor: fullname: Hoogstraate – volume: 51 start-page: 702 year: 1971 ident: 10.1016/S0168-3659(98)00187-4_BIB2 article-title: Permeability of the skin publication-title: Physiol. Rev. doi: 10.1152/physrev.1971.51.4.702 contributor: fullname: Scheuplein – volume: 96 start-page: 43 year: 1991 ident: 10.1016/S0168-3659(98)00187-4_BIB34 article-title: Oriented structure in human statum corneum revealed by X-ray diffraction publication-title: J. Invest. Dermatol. doi: 10.1111/1523-1747.ep12514716 contributor: fullname: Garson – volume: 19 start-page: 143 year: 1992 ident: 10.1016/S0168-3659(98)00187-4_BIB60 article-title: Solid phase behavior of lipids in porcine stratum corneum publication-title: Proc. Int. Symp. Control. Rel. Bioact. Mater. contributor: fullname: Ongpipattanakul – volume: 81 start-page: 4 year: 1969 ident: 10.1016/S0168-3659(98)00187-4_BIB1 article-title: Transport into and within the skin publication-title: Br. J. Dermatol. doi: 10.1111/j.1365-2133.1969.tb16056.x contributor: fullname: Blank – volume: 1153 start-page: 289 year: 1993 ident: 10.1016/S0168-3659(98)00187-4_BIB55 article-title: Enhanced permeation and stratum corneum structural alterations in the presence of dithiothreitol publication-title: Biochim. Biophys. Acta doi: 10.1016/0005-2736(93)90418-Y contributor: fullname: Goates – volume: 1195 start-page: 169 year: 1994 ident: 10.1016/S0168-3659(98)00187-4_BIB78 article-title: Enhanced permeation of polar compounds through human epidermis. I. Permeability and membrane structural changes in the presence of short chain alcohols publication-title: Biochim. Biophys. Acta doi: 10.1016/0005-2736(94)90024-8 contributor: fullname: Goates – ident: 10.1016/S0168-3659(98)00187-4_BIB27 – volume: 28 start-page: 277 year: 1994 ident: 10.1016/S0168-3659(98)00187-4_BIB79 article-title: Selective extraction of stratum corneum components to probe mechanisms of enhanced percutaneous absorption publication-title: J. Control. Rel. doi: 10.1016/0168-3659(94)90179-1 contributor: fullname: Oakeson – volume: 91 start-page: 323 year: 1988 ident: 10.1016/S0168-3659(98)00187-4_BIB91 article-title: Action of penetration enhancers on human skin as assessed by the permeation of model drugs 5-fluorouracil and estradiol. I. Infinite dose technique. publication-title: J. Invest. Dermatol. doi: 10.1111/1523-1747.ep12475655 contributor: fullname: Goodman – volume: 7 start-page: 621 year: 1990 ident: 10.1016/S0168-3659(98)00187-4_BIB62 article-title: Oleic acid: its effects on stratum corneum in relation to (trans)dermal drug delivery publication-title: Pharm. Res. doi: 10.1023/A:1015822312426 contributor: fullname: Francoeur – volume: 80 start-page: 44s year: 1983 ident: 10.1016/S0168-3659(98)00187-4_BIB50 article-title: Epidermal lipids, barrier function, and desquamation publication-title: J. Invest. Dermatol. doi: 10.1038/jid.1983.12 contributor: fullname: Elias – volume: 144 start-page: 81 year: 1996 ident: 10.1016/S0168-3659(98)00187-4_BIB83 article-title: Changes in lipid organisation of the skin barrier by N-alkyl-azocycloheptanones: a visualisation and X-ray diffraction study publication-title: Int. J. Pharm. doi: 10.1016/S0378-5173(96)04726-6 contributor: fullname: Bouwstra – ident: 10.1016/S0168-3659(98)00187-4_BIB13 – volume: 6 start-page: 51 year: 1987 ident: 10.1016/S0168-3659(98)00187-4_BIB103 article-title: Skin development and permeability publication-title: J. Control. Rel. doi: 10.1016/0168-3659(87)90063-0 contributor: fullname: Kurihara-Bergstrom – volume: 24 start-page: 27 year: 1991 ident: 10.1016/S0168-3659(98)00187-4_BIB28 article-title: The biochemistry and function of stratum corneum lipids publication-title: Adv. Lipid Res. doi: 10.1016/B978-0-12-024924-4.50006-7 contributor: fullname: Schurer – volume: 84 start-page: 205 year: 1992 ident: 10.1016/S0168-3659(98)00187-4_BIB35 article-title: Structure of human stratum corneum as a function of temperature and hydration: A wide-angle X-ray diffraction study publication-title: Int. J. Pharm. doi: 10.1016/0378-5173(92)90158-X contributor: fullname: Bouwstra – volume: 65 start-page: 211 year: 1990 ident: 10.1016/S0168-3659(98)00187-4_BIB99 article-title: Mixed monolayers of dipalmitoylphopsphatidylcholine with Azone or oleic acid at the air–water interface publication-title: Int. J. Pharm. doi: 10.1016/0378-5173(90)90145-T contributor: fullname: Lewis – volume: 103 start-page: 233 year: 1994 ident: 10.1016/S0168-3659(98)00187-4_BIB42 article-title: Characterization of low-temperature (i.e., <65°C) lipid transitions in human stratum corneum publication-title: J. Invest. Dermatol. doi: 10.1111/1523-1747.ep12393214 contributor: fullname: Gay – volume: 46 start-page: 19 year: 1988 ident: 10.1016/S0168-3659(98)00187-4_BIB87 article-title: Effect of primary alcohols on percutaneous absorption publication-title: Int. J. Pharm. doi: 10.1016/0378-5173(88)90004-X contributor: fullname: Tsuzuki |
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| SubjectTerms | Animals Biological and medical sciences Epidermis - anatomy & histology Epidermis - chemistry Ethanol - chemistry General pharmacology Humans Lipid layers Lipids - chemistry Medical sciences Penetration enhancers Permeability Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Proteins - metabolism Skin Skin Absorption - drug effects Spectrum Analysis Stratum corneum Water - chemistry |
| Title | Chemical enhancement of percutaneous absorption in relation to stratum corneum structural alterations |
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