T Cell-based RAS Activity and Insulin Levels in Obese Subjects with Low Grade Inflammation

• Published in: The American journal of the medical sciences Vol. 363; no. 5; p. 428
• Main Authors: Coppo, M, Bandinelli, M, Chiostri, M, Modesti, P A, Poggesi, L, Boddi, M
• Format: Journal Article
• Language: English
• Published: United States 01.05.2022
• Subjects: Angiotensin II - metabolism; C-Reactive Protein - metabolism; Cytokines - metabolism; Humans; Inflammation - metabolism; Insulin - metabolism; Insulin Resistance; Obesity; Peptidyl-Dipeptidase A - genetics; Peptidyl-Dipeptidase A - metabolism; Renin-Angiotensin System; T-Lymphocytes - metabolism; Obesity; Insulin resistance; T-cell; Angiotensin II; Renin-angiotensin system

Obesity is a major contributor to inflammation and oxidative stress that are key underlying causes for insulin resistance (IR) and diabetes. Accumulated evidence suggest that RAS may serve as a strong link between IR and obesity. We investigated RAS activity in circulating T cells by obese subjects...