Motility of efferent duct cilia aids passage of sperm cells through the male reproductive system

• Published in: Molecular human reproduction Vol. 27; no. 3
• Main Authors: Aprea, Isabella, Nöthe-Menchen, Tabea, Dougherty, Gerard W, Raidt, Johanna, Loges, Niki T, Kaiser, Thomas, Wallmeier, Julia, Olbrich, Heike, Strünker, Timo, Kliesch, Sabine, Pennekamp, Petra, Omran, Heymut
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 27.02.2021
• Subjects: Animals; Axonemal Dyneins - genetics; Axonemal Dyneins - metabolism; Axoneme - genetics; Axoneme - metabolism; Axoneme - ultrastructure; Cilia - genetics; Cilia - metabolism; Cilia - ultrastructure; Ciliary Motility Disorders - genetics; Ciliary Motility Disorders - metabolism; Ciliary Motility Disorders - pathology; Genetic Predisposition to Disease; Genitalia, Male - metabolism; Genitalia, Male - ultrastructure; Humans; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Transgenic; Movement; Mutation; Oligospermia - genetics; Oligospermia - metabolism; Oligospermia - pathology; Original Research; Phenotype; Sperm Motility; Spermatozoa - pathology; Spermatozoa - ultrastructure; efferent ducts / cilia / sperm / motor proteins / outer dynein arm-defects / DNAH5 / 45 male infertility / oligozoospermia / motile ciliopathy / primary ciliary dyskinesia

Motile cilia line the efferent ducts of the mammalian male reproductive tract. Several recent mouse studies have demonstrated that a reduced generation of multiple motile cilia in efferent ducts is associated with obstructive oligozoospermia and fertility issues. However, the sole impact of efferent...