Post-transcriptional regulation of mouse neurogenesis by Pumilio proteins

• Published in: Genes & development Vol. 31; no. 13; pp. 1354 - 1369
• Main Authors: Zhang, Meng, Chen, Dong, Xia, Jing, Han, Wenqi, Cui, Xiekui, Neuenkirchen, Nils, Hermes, Gretchen, Sestan, Nenad, Lin, Haifan
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.07.2017
• Subjects: Research Paper; mouse; neural stem cell; hippocampus; FMRP; post-transcriptional regulation; mRNA; Pumilio

Despite extensive studies on mammalian neurogenesis, its post-transcriptional regulation remains under-explored. Here we report that neural-specific inactivation of two murine post-transcriptional regulators, Pumilio 1 (Pum1) and Pum2, severely reduced the number of neural stem cells (NSCs) in the p...