Influence of exercise on serum brain-derived neurotrophic factor concentrations in healthy human subjects

The effect of short-term exercise (15 min step-exercise) on serum brain-derived neurotrophic factor (BDNF) levels was evaluated in healthy human subjects. Results showed a short-term, significant increase in serum BDNF levels after exercise. Intra-individual differences in serum BDNF levels were rem...

Full description

Saved in:

Bibliographic Details
Published in	Neuroscience letters Vol. 431; no. 1; pp. 62 - 65
Main Authors	Tang, Siu Wa, Chu, Emily, Hui, Tomy, Helmeste, Daiga, Law, Cindy
Format	Journal Article
Language	English
Published	Shannon Elsevier Ireland Ltd 24.01.2008 Elsevier
Subjects	Adult Biological and medical sciences Brain - metabolism Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - blood Depressive Disorder - blood Depressive Disorder - physiopathology Exercise Exercise - physiology Female Fundamental and applied biological sciences. Psychology Human Humans Male Physical Fitness - physiology Sample Size Serum Up-Regulation - physiology Vertebrates: nervous system and sense organs Human Serum Brain-derived neurotrophic factor Exercise Physical exercise Brain derived neurotrophic factor
Online Access	Get full text

Cover

Loading…

Abstract	The effect of short-term exercise (15 min step-exercise) on serum brain-derived neurotrophic factor (BDNF) levels was evaluated in healthy human subjects. Results showed a short-term, significant increase in serum BDNF levels after exercise. Intra-individual differences in serum BDNF levels were remarkably small on the rest day and also when compared to rest values on the day of the exercise test. Inter-individual differences, on the other hand, were larger by comparison. The result of this study supports the need for larger sample size in studies on BDNF changes in psychiatric disorders or psychiatric drug effects.
AbstractList	The effect of short-term exercise (15 min step-exercise) on serum brain-derived neurotrophic factor (BDNF) levels was evaluated in healthy human subjects. Results showed a short-term, significant increase in serum BDNF levels after exercise. Intra-individual differences in serum BDNF levels were remarkably small on the rest day and also when compared to rest values on the day of the exercise test. Inter-individual differences, on the other hand, were larger by comparison. The result of this study supports the need for larger sample size in studies on BDNF changes in psychiatric disorders or psychiatric drug effects.The effect of short-term exercise (15 min step-exercise) on serum brain-derived neurotrophic factor (BDNF) levels was evaluated in healthy human subjects. Results showed a short-term, significant increase in serum BDNF levels after exercise. Intra-individual differences in serum BDNF levels were remarkably small on the rest day and also when compared to rest values on the day of the exercise test. Inter-individual differences, on the other hand, were larger by comparison. The result of this study supports the need for larger sample size in studies on BDNF changes in psychiatric disorders or psychiatric drug effects. The effect of short-term exercise (15 min step-exercise) on serum brain-derived neurotrophic factor (BDNF) levels was evaluated in healthy human subjects. Results showed a short-term, significant increase in serum BDNF levels after exercise. Intra-individual differences in serum BDNF levels were remarkably small on the rest day and also when compared to rest values on the day of the exercise test. Inter-individual differences, on the other hand, were larger by comparison. The result of this study supports the need for larger sample size in studies on BDNF changes in psychiatric disorders or psychiatric drug effects. The effect of short-term exercise (15 min step-exercise) on serum brain-derived neurotrophic factor (BDNF) levels was evaluated in healthy human subjects. Results showed a short-term, significant increase in serum BDNF levels after exercise. Intra-individual differences in serum BDNF levels were remarkably small on the rest day and also when compared to rest values on the day of the exercise test. Inter-individual differences, on the other hand, were larger by comparison. The result of this study supports the need for larger sample size in studies on BDNF changes in psychiatric disorders or psychiatric drug effects.
Author	Hui, Tomy Chu, Emily Law, Cindy Tang, Siu Wa Helmeste, Daiga
Author_xml	– sequence: 1 givenname: Siu Wa surname: Tang fullname: Tang, Siu Wa organization: Department of Psychiatry, University of Hong Kong, Hong Kong – sequence: 2 givenname: Emily surname: Chu fullname: Chu, Emily organization: Department of Psychiatry, University of Hong Kong, Hong Kong – sequence: 3 givenname: Tomy surname: Hui fullname: Hui, Tomy organization: Department of Psychiatry, University of Hong Kong, Hong Kong – sequence: 4 givenname: Daiga surname: Helmeste fullname: Helmeste, Daiga email: dhelmest@uci.edu organization: Department of Psychiatry, University of California, Psychiatry North Campus Zot 1681, Irvine, CA 92697-1681, USA – sequence: 5 givenname: Cindy surname: Law fullname: Law, Cindy organization: Department of Psychiatry, University of Hong Kong, Hong Kong
BackLink	http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20031970$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/18068900$$D View this record in MEDLINE/PubMed
BookMark	eNp9kc1u1DAYRS1URKeFN0DIG9glfP5JnLBAQhU_lSqxgbXlsb9oPErswXYq-vZ4mKELFl3Zi3OvrXOvyEWIAQl5zaBlwPr3-zbgOmNpOYBqGWuBjc_Ihg2KN2pU_IJsQIBsxCjhklzlvAeAjnXyBblkA_TDCLAh_jZM84rBIo0Txd-YrM_1HmjGtC50m4wPjcPk79HR-mKKJcXDzls6GVtiojbWcCjJFB9Dpj7QHZq57B7obl1M7Vm3e7QlvyTPJzNnfHU-r8nPL59_3Hxr7r5_vb35dNdY2fWl4X3XgxxQ9k6AATVxcAx6LrgzzjmhtgMTKJzolGUDGzhaIwEHw3vBlBvFNXl36j2k-GvFXPTis8V5NgHjmrUCLmRVVsE3Z3DdLuj0IfnFpAf9T04F3p4Bk62Zp2RClfPIVe-CjerIfThxNsWcE07a-vJXR7XiZ81AHxfTe31a7JhUmjFdF6th-V_48R9Pxz6eYlhV3ntMOlt_nNH5VG1rF_3TBX8AFAuynQ
CODEN	NELED5
CitedBy_id	crossref_primary_10_1179_1743132814Y_0000000428 crossref_primary_10_1016_j_neulet_2016_06_064 crossref_primary_10_3390_ijerph17093317 crossref_primary_10_1007_s00213_014_3475_8 crossref_primary_10_1016_j_jtemb_2021_126753 crossref_primary_10_1007_s11764_014_0404_0 crossref_primary_10_1155_2017_7014146 crossref_primary_10_14814_phy2_14140 crossref_primary_10_1152_jn_01028_2014 crossref_primary_10_3390_ijms21239086 crossref_primary_10_1111_cpr_70026 crossref_primary_10_1016_j_neulet_2010_09_032 crossref_primary_10_1136_bmjsem_2018_000499 crossref_primary_10_1590_S1807_59322010001100012 crossref_primary_10_3389_fpsyg_2018_01405 crossref_primary_10_1016_j_metabol_2012_08_001 crossref_primary_10_2478_hukin_2018_0040 crossref_primary_10_3389_fnrgo_2021_678541 crossref_primary_10_1080_02656736_2021_1922761 crossref_primary_10_1097_JSM_0000000000000082 crossref_primary_10_1007_s40279_017_0787_y crossref_primary_10_1007_s10072_015_2208_z crossref_primary_10_1080_01924788_2021_1910152 crossref_primary_10_1016_j_neulet_2008_10_013 crossref_primary_10_3233_JHD_170273 crossref_primary_10_1016_j_pmrj_2011_02_008 crossref_primary_10_1007_s00421_010_1461_3 crossref_primary_10_1097_JSM_0b013e31827ee6d5 crossref_primary_10_17116_jnevro2023123091131 crossref_primary_10_1038_s41598_023_31703_8 crossref_primary_10_1016_j_clinbiochem_2011_05_008 crossref_primary_10_1080_10749357_2017_1373500 crossref_primary_10_1371_journal_pone_0173672 crossref_primary_10_1016_j_bbr_2015_12_020 crossref_primary_10_3389_fncir_2016_00039 crossref_primary_10_1002_hipo_22805 crossref_primary_10_3233_JAD_181079 crossref_primary_10_1139_apnm_2018_0643 crossref_primary_10_1177_1099800414555411 crossref_primary_10_1016_j_biopsych_2008_05_005 crossref_primary_10_1016_j_psyneuen_2013_12_014 crossref_primary_10_1016_j_neubiorev_2010_07_006 crossref_primary_10_7717_peerj_2883 crossref_primary_10_1111_sms_12069 crossref_primary_10_1152_japplphysiol_00126_2015 crossref_primary_10_1016_j_eplepsyres_2011_10_012 crossref_primary_10_1016_j_neulet_2016_07_033 crossref_primary_10_1016_j_bbi_2011_04_017 crossref_primary_10_5717_jenb_2014_18_1_97 crossref_primary_10_1093_humupd_dmaa008 crossref_primary_10_1136_jim_2016_000390 crossref_primary_10_1177_1087054711417395 crossref_primary_10_1155_2017_3589271 crossref_primary_10_1016_j_neuroscience_2020_12_013 crossref_primary_10_3390_ijerph17218216 crossref_primary_10_3390_genes13071236 crossref_primary_10_1016_j_neulet_2008_12_043 crossref_primary_10_1177_147323000803600501 crossref_primary_10_1590_1414_431x20198154 crossref_primary_10_1016_j_bbr_2017_06_002 crossref_primary_10_1007_s00421_010_1658_5 crossref_primary_10_1016_j_livsci_2015_08_006 crossref_primary_10_1016_j_neulet_2012_05_025 crossref_primary_10_1038_s41598_020_77046_6 crossref_primary_10_2478_msp_2024_0038 crossref_primary_10_3390_biology12081089 crossref_primary_10_1007_BF03400934 crossref_primary_10_5352_JLS_2012_22_9_1231 crossref_primary_10_1016_j_bbi_2011_09_015 crossref_primary_10_1371_journal_pone_0064172 crossref_primary_10_1016_j_jshs_2020_01_004 crossref_primary_10_1152_japplphysiol_01378_2012 crossref_primary_10_1152_physiol_00019_2013 crossref_primary_10_2217_pme_10_33 crossref_primary_10_1371_journal_pone_0089455 crossref_primary_10_1016_j_yhbeh_2022_105233 crossref_primary_10_1017_neu_2021_47 crossref_primary_10_1371_journal_pone_0022966 crossref_primary_10_1016_j_psychres_2014_03_011 crossref_primary_10_1027_0269_8803_a000131 crossref_primary_10_1016_j_bandc_2016_08_002 crossref_primary_10_1007_s00221_021_06086_9 crossref_primary_10_1007_s12264_011_1531_5 crossref_primary_10_1016_j_jshs_2014_11_001 crossref_primary_10_1186_2193_1801_2_678 crossref_primary_10_46497_ArchRheumatol_2023_9599 crossref_primary_10_1038_s41598_021_88496_x crossref_primary_10_1007_s11920_012_0297_4 crossref_primary_10_36660_abc_20190368 crossref_primary_10_1113_expphysiol_2009_048512 crossref_primary_10_3109_15622975_2011_639800 crossref_primary_10_3233_NHA_1615 crossref_primary_10_1016_j_psyneuen_2009_07_013 crossref_primary_10_1155_2019_5413067 crossref_primary_10_3390_brainsci14040320 crossref_primary_10_1016_j_neuroscience_2019_04_054 crossref_primary_10_1016_j_resp_2018_07_011 crossref_primary_10_1177_1849454418806136 crossref_primary_10_1080_02701367_2018_1438575 crossref_primary_10_1089_acm_2013_0266 crossref_primary_10_1155_2017_7260130 crossref_primary_10_1017_neu_2021_13 crossref_primary_10_1080_16506073_2015_1012740 crossref_primary_10_1016_j_neuroscience_2017_07_031 crossref_primary_10_1249_MSS_0000000000002064 crossref_primary_10_1515_teb_2024_0038 crossref_primary_10_1016_j_neulet_2013_12_004 crossref_primary_10_1016_j_jpsychires_2014_10_003 crossref_primary_10_1016_j_neuroscience_2012_07_019 crossref_primary_10_3389_fnins_2024_1434309 crossref_primary_10_1016_j_pmrj_2016_05_004 crossref_primary_10_12968_bjnn_2008_4_11_31691 crossref_primary_10_1016_j_neulet_2010_05_058 crossref_primary_10_1155_2015_380615 crossref_primary_10_1016_j_neulet_2014_02_011 crossref_primary_10_1080_1354750X_2021_2024602 crossref_primary_10_5717_jenb_2014_18_1_61 crossref_primary_10_1016_j_psyneuen_2014_05_011 crossref_primary_10_1002_ajmg_b_32616 crossref_primary_10_15726_jkd_2011_29_1_012 crossref_primary_10_1016_j_clinbiochem_2014_11_013 crossref_primary_10_1016_j_neulet_2010_11_035 crossref_primary_10_1016_j_arr_2018_10_002 crossref_primary_10_1080_10749357_2024_2356393 crossref_primary_10_1155_2016_6860573 crossref_primary_10_12965_jer_1632808_404 crossref_primary_10_1089_cap_2011_0009 crossref_primary_10_1017_S1461145709991234 crossref_primary_10_1080_00222895_2014_983450 crossref_primary_10_1123_jsep_2019_0224 crossref_primary_10_1519_JSC_0000000000004851 crossref_primary_10_1016_j_ijcard_2012_11_055 crossref_primary_10_1016_j_beth_2018_09_007 crossref_primary_10_3389_fnagi_2017_00422 crossref_primary_10_1016_j_bbr_2022_113864 crossref_primary_10_1016_j_mehy_2012_05_002 crossref_primary_10_1016_j_pnpbp_2008_08_005 crossref_primary_10_1536_ihj_19_400 crossref_primary_10_2337_dc11_1295 crossref_primary_10_5497_wjp_v2_i4_92 crossref_primary_10_1016_j_neuroscience_2020_03_042 crossref_primary_10_1017_S1041610212001299 crossref_primary_10_1016_j_physbeh_2011_06_005 crossref_primary_10_1111_ejn_13719 crossref_primary_10_3390_biom9100630 crossref_primary_10_1038_bjp_2008_163 crossref_primary_10_18632_aging_101166 crossref_primary_10_1016_j_mhpa_2024_100578 crossref_primary_10_1016_j_physbeh_2016_08_011 crossref_primary_10_1002_hipo_20579 crossref_primary_10_1152_jn_00419_2017 crossref_primary_10_1080_10790268_2020_1816402 crossref_primary_10_1038_s41386_019_0391_y crossref_primary_10_1016_j_jaac_2013_05_018 crossref_primary_10_1007_s11892_020_01319_7 crossref_primary_10_1113_EP085682 crossref_primary_10_1080_01616412_2018_1564451 crossref_primary_10_1016_j_jpsychires_2012_05_003 crossref_primary_10_1016_j_neuroscience_2019_05_051 crossref_primary_10_29252_aassjournal_6_4_17 crossref_primary_10_3233_BPL_180069 crossref_primary_10_3389_fphys_2023_1268648 crossref_primary_10_1002_gps_2462 crossref_primary_10_1007_s00213_008_1333_2 crossref_primary_10_1007_s00421_022_05078_z crossref_primary_10_4065_mcp_2011_0252 crossref_primary_10_1016_j_nlm_2017_03_012 crossref_primary_10_2165_11534530_000000000_00000 crossref_primary_10_1016_j_bandc_2012_09_001 crossref_primary_10_13005_bpj_1760 crossref_primary_10_1589_jpts_31_550 crossref_primary_10_1016_j_neulet_2013_12_034 crossref_primary_10_1016_j_psyneuen_2010_07_013 crossref_primary_10_1016_j_physbeh_2016_12_026 crossref_primary_10_3389_fneur_2024_1505879 crossref_primary_10_3109_15622975_2010_545187
Cites_doi	10.1016/0006-3223(92)90051-Z 10.1016/j.neurobiolaging.2004.03.002 10.1016/S0166-2236(02)02143-4 10.1126/science.1129663 10.1016/S0165-1781(02)00005-7 10.1016/S0924-9338(03)00006-3 10.1016/j.brainres.2006.08.105 10.1523/JNEUROSCI.10-11-03469.1990 10.1016/j.biopsych.2005.01.008 10.1016/j.jns.2004.06.009 10.1001/archpsyc.57.9.875 10.1084/jem.189.5.865 10.1016/j.neulet.2005.12.085 10.1210/jc.2002-020838 10.1016/S0304-3940(02)00529-3 10.1056/NEJM198705213162105 10.1016/j.neures.2005.06.008 10.1523/JNEUROSCI.3741-04.2005 10.1001/archpsyc.1985.01790260086010 10.1016/S0014-5793(00)01302-8 10.1186/1479-5876-4-40 10.1016/S0165-5728(03)00121-8 10.1038/sj.mp.4001941
ContentType	Journal Article
Copyright	2007 Elsevier Ireland Ltd 2008 INIST-CNRS
Copyright_xml	– notice: 2007 Elsevier Ireland Ltd – notice: 2008 INIST-CNRS
DBID	AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8
DOI	10.1016/j.neulet.2007.11.019
DatabaseName	CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine Anatomy & Physiology
EISSN	1872-7972
EndPage	65
ExternalDocumentID	18068900 20031970 10_1016_j_neulet_2007_11_019 S0304394007011949
Genre	Journal Article
GroupedDBID	--- --K --M -~X .55 .GJ .~1 0R~ 123 1B1 1RT 1~. 1~5 29N 4.4 457 4G. 53G 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AADPK AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXLA AAXUO ABCQJ ABFNM ABFRF ABJNI ABLJU ABMAC ABTAH ABXDB ABYKQ ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE ADIYS ADMUD AEBSH AEFWE AEKER AENEX AETEA AFKWA AFTJW AFXIZ AGHFR AGUBO AGWIK AGYEJ AHHHB AHPSJ AIEXJ AIKHN AITUG AJBFU AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HMQ HVGLF HZ~ IHE J1W KOM M2V M41 MO0 MOBAO MVM N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SCC SDF SDG SDP SES SEW SNS SPCBC SSN SSZ T5K WH7 WUQ X7M YCJ ZGI ZXP ZY4 ~G- AATTM AAXKI AAYWO AAYXX ABWVN ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFJKZ AFPUW AGCQF AGQPQ AGRNS AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP BNPGV CITATION SSH EFKBS IQODW CGR CUY CVF ECM EIF NPM 7X8
ID	FETCH-LOGICAL-c456t-2656048e46d30a07f20d106232daddd37b813e3d357c18182eca40e8a26317d93
IEDL.DBID	AIKHN
ISSN	0304-3940
IngestDate	Fri Jul 11 06:09:15 EDT 2025 Thu Apr 03 07:05:49 EDT 2025 Mon Jul 21 09:11:49 EDT 2025 Tue Jul 01 00:59:11 EDT 2025 Thu Apr 24 23:04:24 EDT 2025 Fri Feb 23 02:27:49 EST 2024
IsPeerReviewed	true
IsScholarly	true
Issue	1
Keywords	Human Serum Brain-derived neurotrophic factor Exercise Physical exercise Brain derived neurotrophic factor
Language	English
License	https://www.elsevier.com/tdm/userlicense/1.0 CC BY 4.0
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c456t-2656048e46d30a07f20d106232daddd37b813e3d357c18182eca40e8a26317d93
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
PMID	18068900
PQID	70234007
PQPubID	23479
PageCount	4
ParticipantIDs	proquest_miscellaneous_70234007 pubmed_primary_18068900 pascalfrancis_primary_20031970 crossref_citationtrail_10_1016_j_neulet_2007_11_019 crossref_primary_10_1016_j_neulet_2007_11_019 elsevier_sciencedirect_doi_10_1016_j_neulet_2007_11_019
ProviderPackageCode	CITATION AAYXX
PublicationCentury	2000
PublicationDate	2008-01-24
PublicationDateYYYYMMDD	2008-01-24
PublicationDate_xml	– month: 01 year: 2008 text: 2008-01-24 day: 24
PublicationDecade	2000
PublicationPlace	Shannon
PublicationPlace_xml	– name: Shannon – name: Ireland
PublicationTitle	Neuroscience letters
PublicationTitleAlternate	Neurosci Lett
PublicationYear	2008
Publisher	Elsevier Ireland Ltd Elsevier
Publisher_xml	– name: Elsevier Ireland Ltd – name: Elsevier
References	Karege, Schwald, Cissc (bib8) 2002; 328 Yamamoto, Gurney (bib25) 1990; 10 Karege, Bondolfi, Gervasoni, Schwald, Aubry, Bertschy (bib9) 2005; 57 Wolff, Putnam, Post (bib24) 1985; 42 Andersson, Carlsen, Petersen, Skakkebaek (bib1) 2003; 88 Musselman, Marzec, Manatunga, Penna, Reemsnyder, Knight, Baron, Hanson, Nemeroff (bib16) 2000; 57 Vega, Struder, Wahrmann, Schmidt, Bloch, Hollmann (bib23) 2006; 1121 Schulz, Gold, Witte, Bartsch, Lang, Hellweg, Reer, Braumann, Heesen (bib20) 2004; 225 Gold, Schulz, Hartmann, Mladek, Lang, Hellweg, Reer, Braumann, Heesen (bib6) 2003; 138 Chen, Jing, Bath, Ieraci, Khan, Siao, Herrera, Toth, Yang, McEwen, Hempstead, Lee (bib3) 2006; 314 Nakahashi, Fujimura, Altar, Li, Kambayashi, Tandon, Sun (bib17) 2000; 470 Sairanen, Lucas, Ernfors, Castren, Castren (bib19) 2005; 25 Cotman, Berchtold (bib4) 2002; 25 Lommatzsch, Zingler, Schuhbaeck, Schloetcke, Zingler, Schuff-Werner, Christian Virchow (bib13) 2005; 26 Klein, Lavie, Meiraz, Sadeh, Lenox (bib11) 1992; 31 Cunha, Frey, Andreazza, Goi, Rosa, Goncalves, Santin, Kapczinski (bib5) 2006; 398 Karege, Perret, Bondolfi, Schwald, Bertschy, Aubry (bib7) 2002; 109 Ayache, Panelli, Byrne, Slezak, Leitman, Marincola, Stroncek (bib2) 2006; 4 Lederbogen, Horer, Hellweg, Heuser, Deuschle (bib12) 2003; 18 S.W. Tang, P. Liu, D. Helmeste, E. Chen, Plasma BDNF level in psychiatric patients and normal controls, in: World Federation of Societies of Biological Psychiatry, 2004 Asia-Pacific Congress and 41st Meeting of KSBP, 9–11 July 2004, Seoul, Korea. Luger, Deuster, Kyle, Gallucci, Montgomery, Gold, Loriaux, Chrousos (bib14) 1987; 316 Murakami, Imbe, Morikawa, Kubo, Senba (bib15) 2005; 53 A. Piccinni, D. Marazziti, M. Catena, L. Domenici, A. Del Debbio, C. Bianchi, C. Mannari, C. Martini, E. Da Pozzo, E. Shiavi, A. Mariotti, I. Roncaglia, A. Palla, G. Consoli, L. Giovannini, G. Masssimetti, L. Dell’osso, Plasma and serum brain-derived neurotrophic factor (BDNF) in depressed patients during 1 year of antidepressant treatments, J. Affect. Disord., in press [Epub ahead of print, 5 June 2007]. Kerschensteiner, Gallmeier, Behrens, Leal, Misgeld, Klinkert, Kolbeck, Hoppe, Oropeza-Wekerle, Bartke, Stadelmann, Lassmann, Wekerle, Hohlfeld (bib10) 1999; 189 Tramontina, Frey, Andreazza, Zandona, Santin, Kapczinski (bib22) 2007; 12 Andersson (10.1016/j.neulet.2007.11.019_bib1) 2003; 88 Wolff (10.1016/j.neulet.2007.11.019_bib24) 1985; 42 Cunha (10.1016/j.neulet.2007.11.019_bib5) 2006; 398 Ayache (10.1016/j.neulet.2007.11.019_bib2) 2006; 4 10.1016/j.neulet.2007.11.019_bib21 Karege (10.1016/j.neulet.2007.11.019_bib7) 2002; 109 Schulz (10.1016/j.neulet.2007.11.019_bib20) 2004; 225 Tramontina (10.1016/j.neulet.2007.11.019_bib22) 2007; 12 10.1016/j.neulet.2007.11.019_bib18 Luger (10.1016/j.neulet.2007.11.019_bib14) 1987; 316 Musselman (10.1016/j.neulet.2007.11.019_bib16) 2000; 57 Klein (10.1016/j.neulet.2007.11.019_bib11) 1992; 31 Vega (10.1016/j.neulet.2007.11.019_bib23) 2006; 1121 Sairanen (10.1016/j.neulet.2007.11.019_bib19) 2005; 25 Lederbogen (10.1016/j.neulet.2007.11.019_bib12) 2003; 18 Cotman (10.1016/j.neulet.2007.11.019_bib4) 2002; 25 Karege (10.1016/j.neulet.2007.11.019_bib9) 2005; 57 Murakami (10.1016/j.neulet.2007.11.019_bib15) 2005; 53 Gold (10.1016/j.neulet.2007.11.019_bib6) 2003; 138 Nakahashi (10.1016/j.neulet.2007.11.019_bib17) 2000; 470 Yamamoto (10.1016/j.neulet.2007.11.019_bib25) 1990; 10 Chen (10.1016/j.neulet.2007.11.019_bib3) 2006; 314 Karege (10.1016/j.neulet.2007.11.019_bib8) 2002; 328 Kerschensteiner (10.1016/j.neulet.2007.11.019_bib10) 1999; 189 Lommatzsch (10.1016/j.neulet.2007.11.019_bib13) 2005; 26
References_xml	– volume: 88 start-page: 932 year: 2003 end-page: 937 ident: bib1 article-title: Variation in levels of serum inhibin B, testosterone, estradiol, luteinizing hormone, follicle-stimulating hormone, and sex hormone-binding globulin in monthly samples from healthy men during a 17-month period: possible effects of seasons publication-title: J. Clin. Endocrinol. Metab. – volume: 1121 start-page: 59 year: 2006 end-page: 65 ident: bib23 article-title: Acute BDNF and cortisol response to low intensity exercise and following ramp incremental exercise to exhaustion in humans publication-title: Brain Res. – volume: 189 start-page: 865 year: 1999 end-page: 870 ident: bib10 article-title: Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? publication-title: J. Exp. Med. – volume: 314 start-page: 140 year: 2006 end-page: 143 ident: bib3 article-title: Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior publication-title: Science – volume: 26 start-page: 115 year: 2005 end-page: 123 ident: bib13 article-title: The impact of age, weight and gender on BDNF levels in human platelets and plasma publication-title: Neurobiol. Aging – volume: 225 start-page: 11 year: 2004 end-page: 18 ident: bib20 article-title: Impact of aerobic training on immuno-endocrine parameters, neurotrophic factors, quality of life and coordinative function in multiple sclerosis publication-title: J. Neurol. Sci. – volume: 57 start-page: 875 year: 2000 end-page: 882 ident: bib16 article-title: Platelet reactivity in depressed patients treated with paroxetine publication-title: Arch. Gen. Psychiatry – volume: 4 start-page: 40 year: 2006 ident: bib2 article-title: Comparison of proteomic profiles of serum, plasma, and modified media supplements used for cell culture and expansion publication-title: J. Transl. Med. – volume: 138 start-page: 99 year: 2003 end-page: 105 ident: bib6 article-title: Basal serum levels and reactivity of nerve growth factor and brain-derived neurotrophic factor to standardized acute exercise in multiple sclerosis and controls publication-title: J. Neuroimmunol. – volume: 316 start-page: 1309 year: 1987 end-page: 1315 ident: bib14 article-title: Acute hypothalamic-pituitary-adrenal responses to the stress of treadmill exercise. Physiologic adaptations to physical training publication-title: NEJM – reference: A. Piccinni, D. Marazziti, M. Catena, L. Domenici, A. Del Debbio, C. Bianchi, C. Mannari, C. Martini, E. Da Pozzo, E. Shiavi, A. Mariotti, I. Roncaglia, A. Palla, G. Consoli, L. Giovannini, G. Masssimetti, L. Dell’osso, Plasma and serum brain-derived neurotrophic factor (BDNF) in depressed patients during 1 year of antidepressant treatments, J. Affect. Disord., in press [Epub ahead of print, 5 June 2007]. – volume: 42 start-page: 288 year: 1985 end-page: 294 ident: bib24 article-title: Motor activity and affective illness. The relationship of amplitude and temporal distribution to changes in affective state publication-title: Arch. Gen. Psychiatry – volume: 31 start-page: 279 year: 1992 end-page: 284 ident: bib11 article-title: Increased motor activity and recurrent manic episodes: predictors of rapid relapse in remitted bipolar disorder patients after lithium discontinuation publication-title: Biol. Psychiatry – volume: 398 start-page: 215 year: 2006 end-page: 219 ident: bib5 article-title: Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes publication-title: Neurosci. Lett. – volume: 328 start-page: 261 year: 2002 end-page: 264 ident: bib8 article-title: Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets publication-title: Neurosci. Lett. – volume: 53 start-page: 129 year: 2005 end-page: 139 ident: bib15 article-title: Chronic stress, as well as acute stress, reduces BDNF mRNA expression in the rat hippocampus but less robustly publication-title: Neurosci. Res. – volume: 18 start-page: 89 year: 2003 end-page: 91 ident: bib12 article-title: Platelet counts in depressed patients treated with amitriptyline or paroxetine publication-title: Eur. Psychiatry – volume: 109 start-page: 143 year: 2002 end-page: 148 ident: bib7 article-title: Decreased serum brain-derived neurotrophic factor levels in major depressed patients publication-title: Psychiatry Res. – volume: 10 start-page: 3469 year: 1990 end-page: 3478 ident: bib25 article-title: Human platelets contain brain-derived neurotrophic factor publication-title: J. Neurosci. – reference: S.W. Tang, P. Liu, D. Helmeste, E. Chen, Plasma BDNF level in psychiatric patients and normal controls, in: World Federation of Societies of Biological Psychiatry, 2004 Asia-Pacific Congress and 41st Meeting of KSBP, 9–11 July 2004, Seoul, Korea. – volume: 470 start-page: 113 year: 2000 end-page: 117 ident: bib17 article-title: Vascular endothelial cells synthesize and secrete brain-derived neurotrophic factor publication-title: FEBS Lett. – volume: 25 start-page: 1089 year: 2005 end-page: 1094 ident: bib19 article-title: Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus publication-title: J. Neurosci. – volume: 25 start-page: 295 year: 2002 end-page: 301 ident: bib4 article-title: Exercise: a behavioral intervention to enhance brain health and plasticity publication-title: Trends Neurosci. – volume: 57 start-page: 1068 year: 2005 end-page: 1072 ident: bib9 article-title: Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity publication-title: Biol. Psychiatry – volume: 12 start-page: 230 year: 2007 end-page: 231 ident: bib22 article-title: Val66met polymorphism and serum brain-derived neurotrophic factor levels in bipolar disorder publication-title: Mol. Psychiatry – volume: 31 start-page: 279 year: 1992 ident: 10.1016/j.neulet.2007.11.019_bib11 article-title: Increased motor activity and recurrent manic episodes: predictors of rapid relapse in remitted bipolar disorder patients after lithium discontinuation publication-title: Biol. Psychiatry doi: 10.1016/0006-3223(92)90051-Z – volume: 26 start-page: 115 year: 2005 ident: 10.1016/j.neulet.2007.11.019_bib13 article-title: The impact of age, weight and gender on BDNF levels in human platelets and plasma publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2004.03.002 – volume: 25 start-page: 295 year: 2002 ident: 10.1016/j.neulet.2007.11.019_bib4 article-title: Exercise: a behavioral intervention to enhance brain health and plasticity publication-title: Trends Neurosci. doi: 10.1016/S0166-2236(02)02143-4 – volume: 314 start-page: 140 year: 2006 ident: 10.1016/j.neulet.2007.11.019_bib3 article-title: Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior publication-title: Science doi: 10.1126/science.1129663 – volume: 109 start-page: 143 year: 2002 ident: 10.1016/j.neulet.2007.11.019_bib7 article-title: Decreased serum brain-derived neurotrophic factor levels in major depressed patients publication-title: Psychiatry Res. doi: 10.1016/S0165-1781(02)00005-7 – volume: 18 start-page: 89 year: 2003 ident: 10.1016/j.neulet.2007.11.019_bib12 article-title: Platelet counts in depressed patients treated with amitriptyline or paroxetine publication-title: Eur. Psychiatry doi: 10.1016/S0924-9338(03)00006-3 – volume: 1121 start-page: 59 year: 2006 ident: 10.1016/j.neulet.2007.11.019_bib23 article-title: Acute BDNF and cortisol response to low intensity exercise and following ramp incremental exercise to exhaustion in humans publication-title: Brain Res. doi: 10.1016/j.brainres.2006.08.105 – volume: 10 start-page: 3469 year: 1990 ident: 10.1016/j.neulet.2007.11.019_bib25 article-title: Human platelets contain brain-derived neurotrophic factor publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.10-11-03469.1990 – ident: 10.1016/j.neulet.2007.11.019_bib18 – volume: 57 start-page: 1068 year: 2005 ident: 10.1016/j.neulet.2007.11.019_bib9 article-title: Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2005.01.008 – volume: 225 start-page: 11 year: 2004 ident: 10.1016/j.neulet.2007.11.019_bib20 article-title: Impact of aerobic training on immuno-endocrine parameters, neurotrophic factors, quality of life and coordinative function in multiple sclerosis publication-title: J. Neurol. Sci. doi: 10.1016/j.jns.2004.06.009 – ident: 10.1016/j.neulet.2007.11.019_bib21 – volume: 57 start-page: 875 year: 2000 ident: 10.1016/j.neulet.2007.11.019_bib16 article-title: Platelet reactivity in depressed patients treated with paroxetine publication-title: Arch. Gen. Psychiatry doi: 10.1001/archpsyc.57.9.875 – volume: 189 start-page: 865 year: 1999 ident: 10.1016/j.neulet.2007.11.019_bib10 article-title: Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? publication-title: J. Exp. Med. doi: 10.1084/jem.189.5.865 – volume: 398 start-page: 215 year: 2006 ident: 10.1016/j.neulet.2007.11.019_bib5 article-title: Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes publication-title: Neurosci. Lett. doi: 10.1016/j.neulet.2005.12.085 – volume: 88 start-page: 932 year: 2003 ident: 10.1016/j.neulet.2007.11.019_bib1 article-title: Variation in levels of serum inhibin B, testosterone, estradiol, luteinizing hormone, follicle-stimulating hormone, and sex hormone-binding globulin in monthly samples from healthy men during a 17-month period: possible effects of seasons publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2002-020838 – volume: 328 start-page: 261 year: 2002 ident: 10.1016/j.neulet.2007.11.019_bib8 article-title: Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets publication-title: Neurosci. Lett. doi: 10.1016/S0304-3940(02)00529-3 – volume: 316 start-page: 1309 year: 1987 ident: 10.1016/j.neulet.2007.11.019_bib14 article-title: Acute hypothalamic-pituitary-adrenal responses to the stress of treadmill exercise. Physiologic adaptations to physical training publication-title: NEJM doi: 10.1056/NEJM198705213162105 – volume: 53 start-page: 129 year: 2005 ident: 10.1016/j.neulet.2007.11.019_bib15 article-title: Chronic stress, as well as acute stress, reduces BDNF mRNA expression in the rat hippocampus but less robustly publication-title: Neurosci. Res. doi: 10.1016/j.neures.2005.06.008 – volume: 25 start-page: 1089 year: 2005 ident: 10.1016/j.neulet.2007.11.019_bib19 article-title: Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.3741-04.2005 – volume: 42 start-page: 288 year: 1985 ident: 10.1016/j.neulet.2007.11.019_bib24 article-title: Motor activity and affective illness. The relationship of amplitude and temporal distribution to changes in affective state publication-title: Arch. Gen. Psychiatry doi: 10.1001/archpsyc.1985.01790260086010 – volume: 470 start-page: 113 year: 2000 ident: 10.1016/j.neulet.2007.11.019_bib17 article-title: Vascular endothelial cells synthesize and secrete brain-derived neurotrophic factor publication-title: FEBS Lett. doi: 10.1016/S0014-5793(00)01302-8 – volume: 4 start-page: 40 year: 2006 ident: 10.1016/j.neulet.2007.11.019_bib2 article-title: Comparison of proteomic profiles of serum, plasma, and modified media supplements used for cell culture and expansion publication-title: J. Transl. Med. doi: 10.1186/1479-5876-4-40 – volume: 138 start-page: 99 year: 2003 ident: 10.1016/j.neulet.2007.11.019_bib6 article-title: Basal serum levels and reactivity of nerve growth factor and brain-derived neurotrophic factor to standardized acute exercise in multiple sclerosis and controls publication-title: J. Neuroimmunol. doi: 10.1016/S0165-5728(03)00121-8 – volume: 12 start-page: 230 year: 2007 ident: 10.1016/j.neulet.2007.11.019_bib22 article-title: Val66met polymorphism and serum brain-derived neurotrophic factor levels in bipolar disorder publication-title: Mol. Psychiatry doi: 10.1038/sj.mp.4001941
SSID	ssj0005154
Score	2.3493803
Snippet	The effect of short-term exercise (15 min step-exercise) on serum brain-derived neurotrophic factor (BDNF) levels was evaluated in healthy human subjects.... The effect of short-term exercise (15 min step-exercise) on serum brain-derived neurotrophic factor (BDNF) levels was evaluated in healthy human subjects....
SourceID	proquest pubmed pascalfrancis crossref elsevier
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	62
SubjectTerms	Adult Biological and medical sciences Brain - metabolism Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - blood Depressive Disorder - blood Depressive Disorder - physiopathology Exercise Exercise - physiology Female Fundamental and applied biological sciences. Psychology Human Humans Male Physical Fitness - physiology Sample Size Serum Up-Regulation - physiology Vertebrates: nervous system and sense organs
Title	Influence of exercise on serum brain-derived neurotrophic factor concentrations in healthy human subjects
URI	https://dx.doi.org/10.1016/j.neulet.2007.11.019 https://www.ncbi.nlm.nih.gov/pubmed/18068900 https://www.proquest.com/docview/70234007
Volume	431
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3LatwwFL3kAaVQQpv0MWk71aJ0p45sybK8HELDpCXZtIHsjPUwdWnsIR4Xsum398qSEwINgWyNhYV0LZ37OgfgY2Xr2qgqoZan6KDUwtFCWUZzm9UabcBI4wP6p2dydS6-XmQXW3A09cL4ssp49oczfTyt45NFXM3FumkW331SL-h6e94yUWzDbsoLiaa9uzz5tjq7rfRIssAi5ZMAOGDqoBvLvFo34AIFLkNP5-kpd_5_Qz1bVz2uWx0EL-5HpOPNdPwc9iKkJMsw6xew5dp9OFi26E5fXpNPZCzyHKPn-_DkNObSD6A5mfRJSFeTSXqJdC1BqxwuifbiEdSihf5xloy8l5urbv2zMSSI9BDjWx7byLvbk6YloavymozKf6QftI_y9C_h_PjLj6MVjcIL1CCe2tDUM_II5YS0nFUsr1Nm0XVE8GXxOLQ818oHTy3PcoMIQaXOVII5VaUS4Ygt-CvYabvWvQGirEQHxmquPVZwhZZC6VpmhutKJIbPgE-LXZrISu7FMX6XU_nZrzJskRfMzNFhKXGLZkBvRq0DK8cD7-fTPpZ3rKvEi-OBkfM7237zOV_UlxQ5m8GHyQ5K_DN9uqVqXTf0ZY5wyFvnDF4H87idqmJSFYwdPnpab-FpKFxJaCrewc7manDvER1t9By2P_9N5vEf-Af_4g_2
linkProvider	Elsevier
linkToHtml	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9UwFD_MCToQ0U3d9WPLg_gWb9ukbfo4huNOd_fiBnsrzUdZxaWX9VbYi3-75zTtdKAMfC0JDclJ8jsf-f0A3le2ro2qYm5Fgg5KLR0vlI14btNaow2YzFBAf3maLc7l54v0YgMOp7cwVFY5nv3hTB9O6_HLfJzN-app5l8pqRd0vYm3TBYP4KHE7Uu78-PPP-o84jRwSFEKAJtP7-eGIi_vepyewGRIZJ5EuPP3--nJqupw1uogd_FvPDrcS0fP4OkIKNlBGPNz2HB-G3YOPDrTVzfsAxtKPIfY-TY8Wo6Z9B1ojid1EtbWbBJeYq1naJP9FdMkHcEt2ucPZ9nAerm-bleXjWFBoocZevDoR9bdjjWehTeVN2zQ_WNdrynG072A86NPZ4cLPsoucINoas0T4uORysnMiqiK8jqJLDqOCL0sHoZW5FpR6NSKNDeID1TiTCUjp6okQzBiC_ESNn3r3S4wZTN0X6wWmpCCK3Qmla6z1AhdydiIGYhpskszcpKTNMb3cio--1aGJSK5zBzdlRKXaAb8ttcqcHLc0z6f1rG8Y1slXhv39Ny7s-y3v6OSvrjIoxnsT3ZQ4r6kZEvlXdt3ZY5giGxzBq-CefweqooyVUTR6_8e1j48XpwtT8qT49Mvb2ArlLDEPJFvYXN93bt3iJPWem_YB78AO_gQug
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Influence+of+exercise+on+serum+brain-derived+neurotrophic+factor+concentrations+in+healthy+human+subjects&rft.jtitle=Neuroscience+letters&rft.au=Tang%2C+Siu+Wa&rft.au=Chu%2C+Emily&rft.au=Hui%2C+Tomy&rft.au=Helmeste%2C+Daiga&rft.date=2008-01-24&rft.issn=0304-3940&rft.volume=431&rft.issue=1&rft.spage=62&rft_id=info:doi/10.1016%2Fj.neulet.2007.11.019&rft.externalDBID=NO_FULL_TEXT
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0304-3940&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0304-3940&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0304-3940&client=summon