Intrarenal Expression of miRNAs in Patients With Hypertensive Nephrosclerosis

• Published in: American journal of hypertension Vol. 23; no. 1; pp. 78 - 84
• Main Authors: Wang, Gang, Kwan, Bonnie Ching-Ha, Lai, Fernand Mac-Moune, Choi, Paul Cheung-Lung, Chow, Kai-Ming, Li, Philip Kam-Tao, Szeto, Cheuk-Chun
• Format: Journal Article
• Language: English
• Published: Basingstoke Oxford University Press 01.01.2010; Nature Publishing Group
• Subjects: Adult; Aged; Antihypertensive agents; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Blood Pressure; Cardiology. Vascular system; Cardiovascular system; Female; Glomerular Filtration Rate; Homeodomain Proteins - metabolism; Humans; hypertension; Hypertension - complications; Hypertension - physiopathology; Kidney - metabolism; Male; Medical sciences; microRNA; MicroRNAs - metabolism; Middle Aged; Nephrosclerosis - etiology; Nephrosclerosis - genetics; Nephrosclerosis - physiopathology; Pharmacology. Drug treatments; renal disease; Repressor Proteins - metabolism; Severity of Illness Index; Transcription Factors - metabolism; Up-Regulation; Zinc Finger E-box Binding Homeobox 2; Zinc Finger E-box-Binding Homeobox 1; blood pressure; microRNA; hypertension; renal disease; Human; Hypertension; Kidney disease; Urinary system disease; Cardiovascular disease; Arterial pressure; Blood pressure; Intrarenal

Background MicroRNAs (miRNAs) are non-coding, single-stranded RNA molecules that play important roles in a number of physiological and pathological processes. Previous studies showed that miRNAs targeting transcription factors ZEB1 and ZEB2 may repress epithelial–mesenchymal transition (EMT). Method...