Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer

• Published in: Genes & development Vol. 33; no. 11-12; pp. 591 - 609
• Main Authors: Gimple, Ryan C., Bhargava, Shruti, Dixit, Deobrat, Rich, Jeremy N.
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.06.2019
• Subjects: Animals; Brain Neoplasms - genetics; Brain Neoplasms - pathology; Brain Neoplasms - physiopathology; Brain Neoplasms - therapy; Cell Differentiation; Epigenesis, Genetic; Glioblastoma - genetics; Glioblastoma - pathology; Glioblastoma - physiopathology; Glioblastoma - therapy; Humans; Neoplastic Stem Cells - physiology; Review; Tumor Microenvironment; brain tumor; tumor-initiating cell; glioblastoma; glioblastoma stem cell; cancer stem cell

Glioblastoma ranks among the most lethal of all human cancers. Glioblastomas display striking cellular heterogeneity, with stem-like glioblastoma stem cells (GSCs) at the apex. Although the original identification of GSCs dates back more than a decade, the purification and characterization of GSCs r...