Various irrigation fluids affect postoperative brain edema and cellular damage during experimental neurosurgery in rats

• Published in: Surgical neurology Vol. 66; no. 6; pp. 565 - 571
• Main Authors: Doi, Kazuhisa, Kawano, Takeshi, Morioka, Yujiro, Fujita, Yasutaka, Nishimura, Masuhiro
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.12.2006; Elsevier
• Subjects: Animals; Biological and medical sciences; Brain - drug effects; Brain - pathology; Brain - surgery; Brain edema; Brain Edema - etiology; Brain Edema - metabolism; Brain Edema - pathology; Cell Membrane Permeability - drug effects; Cerebrospinal Fluid; Irrigation; Isotonic Solutions - adverse effects; Male; Medical sciences; Neurons - drug effects; Neurons - pathology; Neurosurgery; Neurosurgical Procedures - methods; Pharmaceutical Solutions - adverse effects; Postoperative Complications; Random Allocation; Rats; Rats, Sprague-Dawley; Sodium Chloride - adverse effects; Specific Gravity - drug effects; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Tetrazolium Salts; Therapeutic Irrigation; Irrigation; TTC; HEPES; CSF; Rats; CNS; Brain edema; Cerebrospinal fluid; Neurosurgery; ATP; EB; Postoperative; Nervous system diseases; Rat; Rodentia; Cerebral disorder; Vertebrata; Mammalia; Animal; Surgery; Central nervous system disease; Cerebral edema

This study was conducted to investigate how various irrigation fluids used during neurosurgical procedures affect the degree of postoperative brain edema and cellular damage during experimental neurosurgery in rats. The cerebral cortex was exposed and incised crosswise with a surgical knife under ir...