Astroglial Plasticity in the Hippocampus is Affected by Chronic Psychosocial Stress and Concomitant Fluoxetine Treatment

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 31; no. 8; pp. 1616 - 1626
• Main Authors: Czéh, Boldizsár, Simon, Mária, Schmelting, Barthel, Hiemke, Christoph, Fuchs, Eberhard
• Format: Journal Article
• Language: English
• Published: New York, NY Nature Publishing 01.08.2006; Nature Publishing Group
• Subjects: Animals; Astrocytes - drug effects; Astrocytes - metabolism; Astrocytes - pathology; Biological and medical sciences; Chronic Disease; Fluoxetine - pharmacology; Fluoxetine - toxicity; Hippocampus - drug effects; Hippocampus - metabolism; Hippocampus - pathology; Male; Medical sciences; Neuroglia - drug effects; Neuroglia - metabolism; Neuroglia - pathology; Neuronal Plasticity - drug effects; Neuronal Plasticity - physiology; Neuropharmacology; Pharmacology. Drug treatments; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Stress, Psychological - metabolism; Stress, Psychological - pathology; Tupaia; Volumetric analysis; Psychotropic; Toxicity; hippocampal volume; Neuroglia; Central nervous system; Reuptake inhibitor; glia; Encephalon; Selective serotonin reuptake inhibitor; Number; Plasticity; Antidepressant agent; Stereology; Public health; Serotonin; Fluoxetine; antidepressant; Astrocyte; Psychosocial factor; In vitro; Stress; cell number; Chemotherapy; Chronic; Astroglia; Treatment; Neurotransmitter; Hippocampus

Analysis of post-mortem tissue from patients with affective disorders has revealed a decreased number of glial cells in several brain areas. Here, we examined whether long-term psychosocial stress influences the number and morphology of hippocampal astrocytes in an animal model with high validity fo...