Matrix metalloproteinase-dependent shedding of syndecan-3, a transmembrane heparan sulfate proteoglycan, in Schwann cells

• Published in: Journal of neuroscience research Vol. 73; no. 5; pp. 593 - 602
• Main Authors: Asundi, Vinod K., Erdman, Robert, Stahl, Richard C., Carey, David J.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.09.2003
• Subjects: Age Factors; Animals; Animals, Newborn; Blotting, Western; cell adhesion; Cell Adhesion - physiology; Cells, Cultured; Enzyme Inhibitors - pharmacology; Fluorescent Antibody Technique; Heparan Sulfate Proteoglycans - metabolism; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases - metabolism; Membrane Glycoproteins - analysis; Membrane Glycoproteins - drug effects; Membrane Glycoproteins - genetics; Membrane Glycoproteins - metabolism; MMP; peripheral nerve; Peripheral Nerves - chemistry; Peripheral Nerves - growth & development; Peripheral Nerves - metabolism; Protein Structure, Tertiary; Proteoglycans - analysis; Proteoglycans - drug effects; Proteoglycans - genetics; Proteoglycans - metabolism; Rats; Schwann Cells - chemistry; Schwann Cells - cytology; Schwann Cells - physiology; syndecan; Syndecan-3; Transfection

Schwann cells transiently express the transmembrane heparan sulfate proteoglycan syndecan‐3 during the late embryonic and early postnatal periods of peripheral nerve development. Neonatal rat Schwann cells released soluble syndecan‐3 into the culture medium by a process that was blocked by inhibitio...