SETD2 deficiency promotes renal fibrosis through the TGF‐β/Smad signalling pathway in the absence of VHL

• Published in: Clinical and translational medicine Vol. 13; no. 11; pp. e1468 - n/a
• Main Authors: Liu, Changwei, Ni, Li, Li, Xiaoxue, Rao, Hanyu, Feng, Wenxin, Zhu, Yiwen, Zhang, Wei, Ma, Chunxiao, Xu, Yue, Gui, Liming, Wang, Ziyi, Aji, Rebiguli, Xu, Jin, Gao, Wei‐Qiang, Li, Li
• Format: Journal Article
• Language: English
• Published: Hoboken John Wiley and Sons Inc 01.11.2023; Wiley
• Subjects: epigenetic regulation; renal fibrosis; SET domain‐containing 2 (SETD2); transforming growth factor‐β (TGF‐β)/Smad signalling pathway

Background Renal fibrosis is the final development pathway and the most common pathological manifestation of chronic kidney disease. Epigenetic alteration is a significant intrinsic factor contributing to the development of renal fibrosis. SET domain‐containing 2 (SETD2) is the sole histone H3K36 tr...