Elemental mapping of Neuromelanin organelles of human Substantia Nigra: correlative ultrastructural and chemical analysis by analytical transmission electron microscopy and nano‐secondary ion mass spectrometry - Biesemeier, Antje; Eibl, Oliver; Eswara, Santhana; Audinot, Jean‐Nicolas; Wirtz, Tom; Pezzoli, Gianni; Zucca, Fabio A.; Zecca, Luigi; Schraermeyer, Ulrich (Journal of neurochemistry, 2016)
Keywords: Aged; Aged, 80 and over; analytical electron microscopy; correlative microscopy; Cytoplasmic Granules - metabolism; Electron Probe Microanalysis - methods; Female; Humans; Male; Mass spectrometry; Melanins - metabolism; Microscopy; Microscopy, Electron, Transmission - methods; nano‐secondary ion mass spectrometry; Neurochemistry; Parkinson Disease - metabolism; Parkinson Disease - pathology; Spectrometry, Mass, Secondary Ion - methods; Substantia Nigra - metabolism; Substantia Nigra - ultrastructure; substantia nigra neuromelanin; trace metals; nano-secondary ion mass spectrometry; correlative microscopy; trace metals; substantia nigra neuromelanin; analytical electron microscopy