Patterns and predictors of change in outcome measures in clinical trials in scleroderma: An individual patient meta-analysis of 629 subjects with diffuse cutaneous systemic sclerosis

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 64; no. 10; pp. 3420 - 3429
• Main Authors: Merkel, P. A., Silliman, N. P., Clements, P. J., Denton, C. P., Furst, D. E., Mayes, M. D., Pope, J. E., Polisson, R. P., Streisand, J. B., Seibold, J. R.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.10.2012; Wiley; Wiley Subscription Services, Inc
• Subjects: Adult; Biological and medical sciences; Clinical outcomes; Clinical trials; Clinical Trials as Topic; Diseases of the osteoarticular system; Female; Humans; Male; Medical sciences; Middle Aged; Outcome Assessment, Health Care; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Scleroderma; Scleroderma, Diffuse - drug therapy; Treatment Outcome; Diffuse; Human; Immunopathology; Connective tissue disease; Skin disease; Prognosis; Rheumatology; Autoimmune disease; Systemic disease; Clinical trial; Skin; Predictive factor; Scleroderma

Objective To examine the range and responsiveness to change of clinical outcome measures and study predictors of clinical response in patients with diffuse cutaneous systemic sclerosis (dcSSc) in the context of clinical trials. Methods Data were combined from 629 patients with dcSSc who participated...