Noninvasive Estimation of Cerebral Perfusion Pressure and Zero Flow Pressure in Healthy Volunteers: The Effects of Changes in End-Tidal Carbon Dioxide

• Published in: Anesthesia and analgesia Vol. 96; no. 3; pp. 847 - 851
• Main Authors: Hancock, Sally M., Mahajan, Ravi P., Athanassiou, Labros
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD International Anesthesia Research Society 01.03.2003; Lippincott
• Subjects: Adult; Algorithms; Biological and medical sciences; Blood Pressure - physiology; Brain; Carbon Dioxide - blood; Carbon Dioxide - metabolism; Carbon Dioxide - pharmacology; Cerebrovascular Circulation - physiology; Female; Humans; Hypercapnia - physiopathology; Investigative techniques of hemodynamics; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Middle Cerebral Artery - physiology; Human; Healthy subject; Carbon dioxide; Central nervous system; Intracranial pressure; Pressure; Blood flow; Expired gas; Hypercapnia; Perfusion; Hypocapnia; Arterial pressure; Hemodynamics; Brain (vertebrata)

Zero flow pressure (ZFP) in the cerebral circulation is defined as the arterial pressure at which flow ceases. Noninvasive methods of estimating cerebral perfusion pressure (CPP) and ZFP using transcranial Doppler ultrasonography have been described. There is a paucity of normal physiological data r...