Model-based analyses of bioequivalence crossover trials using the stochastic approximation expectation maximisation algorithm - Dubois, Anne; Lavielle, Marc; Gsteiger, Sandro; Pigeolet, Etienne; Mentré, France (Statistics in medicine, 2011)
Keywords: Algorithms; Approximation; Bias; Bioinformatics; Clinical trials; Clinical Trials as Topic - statistics & numerical data; Computer Science; Computer Simulation - statistics & numerical data; Cross-Over Studies; Expectations; Human Growth Hormone - pharmacokinetics; Humans; Life Sciences; likelihood ratio test; Medical statistics; Models, Biological; Models, Statistical; noncompartmental bioequivalence analysis; Nonlinear Dynamics; nonlinear mixed effects model; pharmacokinetics; Quantitative Methods; Therapeutic Equivalency; two one-sided tests; Wald test; pharmacokinetics; likelihood ratio test; non-compartmental bioequivalence analysis; Wald test; nonlinear mixed effects model; two one-sided tests