Discovery of New Fusion Inhibitor Peptides against SARS-CoV-2 by Targeting the Spike S2 Subunit

• Published in: Biomolecules & therapeutics Vol. 29; no. 3; pp. 282 - 289
• Main Authors: Kandeel, Mahmoud, Yamamoto, Mizuki, Tani, Hideki, Kobayashi, Ayako, Gohda, Jin, Kawaguchi, Yasushi, Park, Byoung Kwon, Kwon, Hyung-Joo, Inoue, Jun-ichiro, Alkattan, Abdallah
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Society of Applied Pharmacology 01.05.2021; 한국응용약물학회
• Subjects: Original; 약학; COVID-19; SARS-CoV-2; Fusion inhibitors; Antiviral drugs

A novel coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), caused a worldwide pandemic. Our aim in this study is to produce new fusion inhibitors against SARS-CoV-2, which can be the basis for developing new antiviral drugs. The fusion core comprising the heptad repeat domain...