Direct visualization of Parkinson's disease by in vivo human brain imaging using 7.0T magnetic resonance imaging
Parkinson's disease (PD) is a neurodegenerative disorder resulting from progressive loss of dopaminergic neurons in the substantia nigra (SN) pars compacta. Therefore, imaging of the SN has been regarded to hold greatest potential for use in the diagnosis of PD. At the 7.0T magnetic resonance i...
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Published in | Movement disorders Vol. 26; no. 4; pp. 713 - 718 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.03.2011
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Parkinson's disease (PD) is a neurodegenerative disorder resulting from progressive loss of dopaminergic neurons in the substantia nigra (SN) pars compacta. Therefore, imaging of the SN has been regarded to hold greatest potential for use in the diagnosis of PD. At the 7.0T magnetic resonance imaging (MRI), it is now possible to delineate clearly the shapes and boundaries of the SN. We scanned eight early and two advanced PD patients, along with nine age‐matched control subjects, using a 7.0T MRI in an attempt to directly visualize the SN and quantify the differences in shape and boundaries of SN between PD subjects in comparison with the normal control subjects. In the normal controls, the boundaries between the SN and crus cerebri appear smooth, and clean “arch” shapes that stretch ventrally from posterior to anterior. In contrast, these smooth and clean arch‐like boundaries were lost in PD subjects. The measured correlation analyses show that, in PD patients, there is age‐dependent correlation and substantially stronger UPDRS motor score‐dependent correlation. These results suggest that, by using 7.0T MRI, it appears possible to use these visible and distinctive changes in morphology as a diagnostic marker of PD. © 2011 Movement Disorder Society |
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Bibliography: | ArticleID:MDS23465 istex:2883EE4D136531306021AE456BFFF705B1FA6953 ark:/67375/WNG-N0JHKB4V-9 Relevant conflicts of interest/financial disclosure: This work was supported by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MOST; 20090065597). Full financial disclosures and author roles can be found in the online version of this article. This work was supported by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MOST; 20090065597). Full financial disclosures and author roles can be found in the online version of this article. Relevant conflicts of interest/financial disclosure The author Zang‐Hee Cho had full access to all of the data in the study, and takes responsibility for the integrity of the data and the accuracy of the data analysis. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0885-3185 1531-8257 |
DOI: | 10.1002/mds.23465 |