Plasma YKL-40 predicts 10-year cardiovascular and all-cause mortality in individuals with type 2 diabetes

• Published in: Clinical endocrinology (Oxford) Vol. 79; no. 2; pp. 185 - 191
• Main Authors: Lin, Chih-Hung, Li, Hung-Yuan, Jiang, Yi-Der, Chang, Tien-Jyun, Chuang, Lee-Ming
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell Publishing Ltd 01.08.2013; Blackwell; Wiley Subscription Services, Inc
• Subjects: Adipokines - blood; Aged; Biological and medical sciences; Biomarkers - blood; Cardiovascular Diseases - mortality; Chitinase-3-Like Protein 1; Coronary Disease - mortality; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - mortality; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Fundamental and applied biological sciences. Psychology; Humans; Lectins - blood; Male; Medical sciences; Middle Aged; Proportional Hazards Models; Prospective Studies; Survival Analysis; Taiwan - epidemiology; Vertebrates: endocrinology; Endocrinopathy; Type 2 diabetes; Human; Cause; Prediction; Metabolic diseases; Cardiovascular disease; Endocrinology; Blood plasma

Summary Objective Elevated YKL‐40 concentrations have been observed in both coronary heart disease (CHD) and diabetes. Thus, YKL‐40 may play a role in pathogenesis of CHD in patients with diabetes. We evaluated whether plasma YKL‐40 concentration can predict all‐cause and cardiovascular mortality in...