A serological survey and characterization of Getah virus in domestic pigs in Thailand, 2017–2018

• Published in: Transboundary and emerging diseases Vol. 69; no. 2; pp. 913 - 918
• Main Authors: Rattanatumhi, Khwankamon, Prasertsincharoen, Noppadol, Naimon, Nattakarn, Kuwata, Ryusei, Shimoda, Hiroshi, Ishijima, Keita, Yonemitsu, Kenzo, Minami, Shohei, Supriyono, Tran, Ngo Thuy Bao, Kuroda, Yudai, Tatemoto, Kango, Virhuez Mendoza, Milagros, Hondo, Eiichi, Rerkamnuaychoke, Worawut, Maeda, Ken, Phichitraslip, Thanmaporn
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.03.2022
• Subjects: Alphavirus - genetics; Animal populations; Animals; Antibodies; blood serum; China; Culicidae; death; Diarrhea; Domestic animals; ELISA; Female; Genomes; Getah virus; Hogs; Nucleotide sequence; nucleotide sequences; Phylogeny; pig; Polls & surveys; Populations; Pregnancy; Reproductive failure; RNA viruses; Russia; serological surveys; Serology; Sus scrofa; Swine; Thailand; Thailand - epidemiology; virus isolation; Viruses; Thailand; China; virus isolation; Getah virus; Thailand; serology; ELISA; pig
• ISSN: 1865-1674; 1865-1682; 1865-1682
• DOI: 10.1111/tbed.14042

Getah virus (GETV) is a mosquito‐borne RNA virus belonging to the family Togaviridae, genus Alphavirus. GETV infection causes diarrhoea and death in piglets, and reproductive failure and abortion in sows. This study conducted a serological survey of GETV infection among domestic pig populations in Thailand. ELISA was used to analyse 1,188 pig serum samples collected from 11 provinces of Thailand during 2017–2018, with 23.1% of the samples being positive for anti‐GETV antibodies. The positive ratio of anti‐GETV antibodies was significantly higher in nursery (67.9%) and older stages (84.5%) of pigs than in finishing stage (14.2%). Furthermore, we successfully isolated GETV from one pig serum, designated as GETV strain GETV/SW/Thailand/2017, and determined the complete genome sequence (11,689 nt). Phylogenetic analysis demonstrated that our isolate was different from the recent GETV group spreading among pig populations in East Asia and formed a cluster with two GETV strains, namely YN12031 (China, 2015) and LEIV16275Mar (Far‐East Russia, 2007). We concluded that two different GETV groups are currently spreading among pig populations in Asian countries.