Multifunctional intracellular matrix metalloproteinases: implications in disease

• Published in: The FEBS journal Vol. 288; no. 24; pp. 7162 - 7182
• Main Authors: Bassiouni, Wesam, Ali, Mohammad A. M., Schulz, Richard
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.12.2021
• Subjects: Animals; cancer; Cardiomyocytes; cardiovascular disease; Cardiovascular Diseases - enzymology; Cytosol; Humans; inflammation; Intracellular; Malignancy; Matrix metalloproteinase; Matrix metalloproteinases; Matrix Metalloproteinases - metabolism; metalloproteinases; Mitochondria; Myocytes; Neoplasms - enzymology; nucleus; Oxidative stress; Pathogenesis; Protease; Proteinase; Proteins; proteolysis; sarcomere; sarcomeres; Substrates; cardiovascular disease; cytosol; inflammation; mitochondria; matrix metalloproteinase; nucleus; cancer; proteolysis; sarcomere

Matrix metalloproteinases (MMPs) are zinc‐dependent endopeptidases that were first discovered as proteases, which target and cleave extracellular proteins. During the past 20 years, however, intracellular roles of MMPs were uncovered and research on this new aspect of their biology expanded. MMP‐2 i...