Brain, the last fortress of sarcoma: Similar dismal outcome but discrepancy of timing of brain metastasis in bone and soft tissue sarcoma
Background and Objective Brain metastasis is a rare but dismal event in sarcomas. However, the pattern of occurrence and the prognostic factors associated with post‐brain metastasis survival (PBMS) are not yet well‐characterized. Methods Sarcoma patients treated at one institute within 10‐year perio...
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Published in | Journal of surgical oncology Vol. 104; no. 7; pp. 765 - 770 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.12.2011
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Background and Objective
Brain metastasis is a rare but dismal event in sarcomas. However, the pattern of occurrence and the prognostic factors associated with post‐brain metastasis survival (PBMS) are not yet well‐characterized.
Methods
Sarcoma patients treated at one institute within 10‐year period were retrospectively reviewed and those with brain metastasis were identified. The incidence of brain metastasis was demonstrated by case per person‐years and cumulative incidence curves. Univariate factors associated with PBMS were analyzed.
Results
Among 611 sarcoma patients, 20 (3.3%) developed brain metastasis. Alveolar soft part sarcoma (ASPS) and osteosarcoma were the most common subtypes. Overall, the cumulative incidence was 3.9% at 5 years and 8.4% at 10 years. However, the incidence in STS patients continued to rise up to 10 years after primary diagnosis, whereas it reached a plateau in bone sarcoma patients at 3 years. Median PBMS was 1.67 months. Univariate factors associated with better PBMS included ASPS histology, initial surgical treatment, and brain irradiation for non‐surgically treated patients.
Conclusion
Our study revealed a discrepancy in the timing of occurrence of brain metastasis between STS and bone sarcoma. However, patients with brain metastasis had a poor prognosis, implicating the brain as the last fortress of sarcoma. J. Surg. Oncol. 2011; 104:765–770. © 2011 Wiley Periodicals, Inc. |
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Bibliography: | ark:/67375/WNG-CL5K8R6P-V Yi-Sheng Chou and Chun-Yu Liu contributed equally to this study. Taiwan Clinical Oncology Research Foundation ArticleID:JSO22011 Department of Health, Taiwan (Center of Excellence for Cancer Research at Taipei Veterans General Hospital - No. DOH99-TD-C-111-007; No. DOH100-TD-C-111-007) istex:49057605F3E5543FA418A4D596C94411C091FF44 Yi‐Sheng Chou and Chun‐Yu Liu contributed equally to this study. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-4790 1096-9098 |
DOI: | 10.1002/jso.22011 |