C4d deposits on the surface of RBCs in trauma patients and interferes with their function

• Published in: Critical care medicine Vol. 42; no. 5; p. e364
• Main Authors: Muroya, Takashi, Kannan, Lakshmi, Ghiran, Ionita C, Shevkoplyas, Sergey S, Paz, Ziv, Tsokos, Maria, Dalle Lucca, Jurandir J, Shapiro, Nathan I, Tsokos, George C
• Format: Journal Article
• Language: English
• Published: United States 01.05.2014
• Subjects: Adult; Aged; Calcium - blood; Case-Control Studies; Complement Activation - physiology; Complement C3b - analysis; Complement C4b; Enzyme-Linked Immunosorbent Assay; Erythrocytes - metabolism; Female; Flow Cytometry; Humans; Injury Severity Score; Male; Middle Aged; Nitric Oxide - blood; Peptide Fragments - blood; Prospective Studies; Wounds and Injuries - blood; Wounds and Injuries - complications
• ISSN: 1530-0293
• DOI: 10.1097/CCM.0000000000000231

Complement system is activated in patients with trauma. Although complement activation is presumed to contribute to organ damage and constitutional symptoms, little is known about the involved mechanisms. Because complement components may deposit on RBCs, we asked whether complement deposits on the...