Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes

• Published in: Hepatology (Baltimore, Md.) Vol. 56; no. 3; pp. 952 - 960
• Main Authors: Abdelmalek, Manal F., Lazo, Mariana, Horska, Alena, Bonekamp, Susanne, Lipkin, Edward W., Balasubramanyam, Ashok, Bantle, John P., Johnson, Richard J., Diehl, Anna Mae, Clark, Jeanne M.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.09.2012; Wiley; Wolters Kluwer Health, Inc
• Subjects: Adenosine Triphosphate - physiology; Biological and medical sciences; Diabetes; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - physiopathology; Diabetes. Impaired glucose tolerance; Dietary Carbohydrates - administration & dosage; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Fructose - administration & dosage; Gastroenterology. Liver. Pancreas. Abdomen; Hepatology; Homeostasis; Humans; Liver cirrhosis; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Metabolic diseases; Middle Aged; Obesity; Obesity - complications; Obesity - physiopathology; Sweetening Agents - administration & dosage; Endocrinopathy; Type 2 diabetes; Human; Obesity; Purine nucleoside; Adenosine; Liver; Nutrition disorder; Homeostasis; Metabolic diseases; Fructose; Gastroenterology; Nutritional status

Fructose consumption predicts increased hepatic fibrosis in those with nonalcoholic fatty liver disease (NAFLD). Because of its ability to lower hepatic adenosine triphosphate (ATP) levels, habitual fructose consumption could result in more hepatic ATP depletion and impaired ATP recovery. The degree...