ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain

• Published in: eLife Vol. 10
• Main Authors: Lim, Jormay, Tai, Hsiao-Hsin, Liao, Wei-Hao, Chu, Ya-Cherng, Hao, Chen-Ming, Huang, Yueh-Chun, Lee, Cheng-Han, Lin, Shao-Shien, Hsu, Sherry, Chien, Ya-Chih, Lai, Dar-Ming, Chen, Wen-Shiang, Chen, Chih-Cheng, Wang, Jaw-Lin
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 27.09.2021; eLife Sciences Publications, Ltd
• Subjects: Acid Sensing Ion Channels - genetics; Acid Sensing Ion Channels - metabolism; Acoustics; Animal models; Animals; ASIC1a; Brain - cytology; Brain - metabolism; Calcium imaging; calcium signal; Calcium Signaling; CHO Cells; Clinical trials; Cricetulus; Cytoskeleton; Cytoskeleton - metabolism; Doublecortin Domain Proteins; Doublecortin Protein; Experiments; Extracellular Signal-Regulated MAP Kinases - metabolism; Gene deletion; Hypothalamus; mechanoreceptor; Mechanotransduction; Mechanotransduction, Cellular; Mice; Mice, Inbred C57BL; Mice, Knockout; micropipette; Microtubule-Associated Proteins - metabolism; Neurogenesis; Neuroimaging; neuron; Neurons - metabolism; Neuropeptides - metabolism; Neuroscience; Phosphorylation; Pressure; Streaming; Time Factors; Ultrasonic imaging; Ultrasonic Waves; Ultrasound; Oregon; United States > US; mouse; ASIC1a; mechanoreceptor; neuroscience; micropipette; neuron; calcium signal; ultrasound

Accumulating evidence has shown transcranial low-intensity ultrasound can be potentially a non-invasive neural modulation tool to treat brain diseases. However, the underlying mechanism remains elusive and the majority of studies on animal models applying rather high-intensity ultrasound that cannot...