The Gene Variants of Maternal/Fetal Renin-Angiotensin System in Preeclampsia: A Hybrid Case-Parent/Mother-Control Study

• Published in: Scientific reports Vol. 7; no. 1; pp. 5087 - 9
• Main Authors: Zhang, Heng, Li, Ying-Xue, Peng, Wei-Jun, Li, Zhi-Wei, Zhang, Chun-Hua, Di, Hai-Hong, Shen, Xian-Ping, Zhu, Jun-Feng, Yan, Wei-Rong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.07.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 45; 45/23; 45/77; 631/208/205/2138; 692/499; Adult; Angiotensin; Angiotensin II; Angiotensinogen; Case-Control Studies; Female; Fetus - metabolism; Fetuses; Gene-Environment Interaction; Genetic Association Studies; Genetic Loci; Genetic Predisposition to Disease; Genotype & phenotype; Humanities and Social Sciences; Humans; Likelihood Functions; multidisciplinary; Offspring; Parents; Peptidyl-dipeptidase A; Polymorphism, Genetic; Polymorphism, Single Nucleotide - genetics; Pre-eclampsia; Pre-Eclampsia - genetics; Preeclampsia; Pregnancy; Renin; Renin-Angiotensin System - genetics; Risk Factors; Risk reduction; Science; Science (multidisciplinary)

Preeclampsia (PE) is a common pregnancy-related complication, and polymorphisms in angiotensinogen ( AGT ), angiotensin-converting enzyme ( ACE ), and angiotensin II type 1 receptor ( AT1R ) are believed to contribute to PE development. We implemented a hybrid study to investigate the influence of m...