Relationship between rs7586085, GALNT3 and CCDC170 gene polymorphisms and the risk of osteoporosis among the Chinese Han population

• Published in: Scientific reports Vol. 12; no. 1; p. 6089
• Main Authors: Zhang, Jiaqiang, Cai, Qinlei, Chen, Wangxue, Huang, Maoxue, Guan, Renyang, Jin, Tianbo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.04.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 692/699; 692/700; Bone density; Carrier Proteins - genetics; Case-Control Studies; China - epidemiology; Chromosomes; Female; GALNT3 gene; Gene polymorphism; Genetic analysis; Genetic Predisposition to Disease; Genotype; Haplotypes; Humanities and Social Sciences; Humans; Middle Aged; multidisciplinary; N-Acetylgalactosaminyltransferases - genetics; Osteoporosis; Osteoporosis - genetics; Polymorphism, Single Nucleotide; Polypeptide N-acetylgalactosaminyltransferase; Risk factors; Science; Science (multidisciplinary); Single-nucleotide polymorphism; China
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-09755-z

Osteoporosis (OP) has plagued many women for years, and bone density loss is an indicator of OP. The purpose of this study was to evaluate the relationship between the polymorphism of the rs7586085, CCDC170 and GALNT3 gene polymorphisms and the risk of OP in the Chinese Han population. Using the Agena MassArray method, we identified six candidate SNPs on chromosomes 2 and 6 in 515 patients with OP and 511 healthy controls. Genetic model analysis was performed to evaluate the significant association between variation and OP risk, and meanwhile, the multiple tests were corrected by false discovery rate (FDR). Haploview 4.2 was used for haplotype analysis. In stratified analysis of BMI ˃ 24, rs7586085, rs6726821, rs6710518, rs1346004, and rs1038304 were associated with the risk of OP based on the results of genetic models among females even after the correction of FDR ( q d  < 0.05). In people at age ≤ 60 years, rs1038304 was associated with an increased risk of OP under genetic models after the correction of FDR ( q d  < 0.05). Our study reported that GALNT3 and CCDC170 gene polymorphisms and rs7586085 are the effective risk factors for OP in the Chinese Han population.