Correlates of neutralizing/SARS-CoV-2-S1-binding antibody response with adverse effects and immune kinetics in BNT162b2-vaccinated individuals

• Published in: Scientific reports Vol. 11; no. 1; pp. 22848 - 10
• Main Authors: Maeda, Kenji, Amano, Masayuki, Uemura, Yukari, Tsuchiya, Kiyoto, Matsushima, Tomoko, Noda, Kenta, Shimizu, Yosuke, Fujiwara, Asuka, Takamatsu, Yuki, Ichikawa, Yasuko, Nishimura, Hidehiro, Kinoshita, Mari, Matsumoto, Shota, Gatanaga, Hiroyuki, Yoshimura, Kazuhisa, Oka, Shin-ichi, Mikami, Ayako, Sugiura, Wataru, Sato, Toshiyuki, Yoshida, Tomokazu, Shimada, Shinya, Mitsuya, Hiroaki
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.11.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250/255/2514; 631/326/590/2293; 631/326/596/4130; Adult; Aged; Antibodies, Neutralizing - blood; Antibodies, Neutralizing - immunology; Antibodies, Neutralizing - pharmacology; Antibodies, Viral - blood; Antibodies, Viral - immunology; Antibody response; BNT162 Vaccine - adverse effects; BNT162 Vaccine - pharmacokinetics; COVID-19; COVID-19 - blood; COVID-19 - immunology; COVID-19 Vaccines - adverse effects; COVID-19 Vaccines - pharmacokinetics; Drug-Related Side Effects and Adverse Reactions; Female; Humanities and Social Sciences; Humans; Immune response; Immunogenicity, Vaccine - immunology; Immunoglobulin G; Immunologic Tests; Japan; Kinetics; Male; Middle Aged; mRNA; multidisciplinary; Neutralization; Prospective Studies; SARS-CoV-2 - genetics; SARS-CoV-2 - immunology; SARS-CoV-2 - pathogenicity; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Side effects; Vaccines; Virions; Japan

While mRNA vaccines against SARS-CoV-2 are exceedingly effective in preventing symptomatic infection, their immune response features remain to be clarified. In the present prospective study, 225 healthy individuals in Japan, who received two BNT162b2 doses, were enrolled. Correlates of BNT162b2-elic...