Molecular characterization of enrofloxacin resistant Actinobacillus pleuropneumoniae isolates
Enrofloxacin (ER) resistant Actinobacillus pleuropneumoniae strains emerged in Taiwan in 2002. The mechanism of ER resistance in A. pleuropneumoniae has not yet been reported. A total of 48 A. pleuropneumoniae isolates were obtained from the lungs of pigs with pleuropneumonia in Taiwan between Septe...
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| Published in | Veterinary microbiology Vol. 142; no. 3-4; pp. 309 - 312 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Amsterdam
Elsevier B.V
19.05.2010
Elsevier |
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| Abstract | Enrofloxacin (ER) resistant Actinobacillus pleuropneumoniae strains emerged in Taiwan in 2002. The mechanism of ER resistance in A. pleuropneumoniae has not yet been reported. A total of 48 A. pleuropneumoniae isolates were obtained from the lungs of pigs with pleuropneumonia in Taiwan between September 2007 and April 2008. Twenty-nine isolates were found to be resistant to enrofloxacin. To understand the mechanisms of A. pleuropneumoniae's resistance to ER, enrofloxacin susceptibility of the isolates along with the mutations of the quinolone resistance-determining region (QRDR) of DNA gyrase and topoisomerase IV, qnr genes were analyzed. Enrofloxacin resistant isolates were found to carry at least one mutation in the QRDR of gyrA, leading to amino acid changes at codon 83 or 87. Efflux pump inhibitor (Phe-Arg-β-naphthylamide) decreased enrofloxacin minimum inhibitory concentration 2–16-fold, suggesting participation of efflux in ER resistance. Plasmid mediated quinolone resistance genes qnr were not detected in these isolates. In conclusion, enrofloxacin resistance of A. pleuropneumoniae may be linked to multiple target gene mutations and active effluxs. |
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| AbstractList | Enrofloxacin (ER) resistant Actinobacillus pleuropneumoniae strains emerged in Taiwan in 2002. The mechanism of ER resistance in A. pleuropneumoniae has not yet been reported. A total of 48 A. pleuropneumoniae isolates were obtained from the lungs of pigs with pleuropneumonia in Taiwan between September 2007 and April 2008. Twenty-nine isolates were found to be resistant to enrofloxacin. To understand the mechanisms of A. pleuropneumoniae's resistance to ER, enrofloxacin susceptibility of the isolates along with the mutations of the quinolone resistance-determining region (QRDR) of DNA gyrase and topoisomerase IV, qnr genes were analyzed. Enrofloxacin resistant isolates were found to carry at least one mutation in the QRDR of gyrA, leading to amino acid changes at codon 83 or 87. Efflux pump inhibitor (Phe-Arg-β-naphthylamide) decreased enrofloxacin minimum inhibitory concentration 2–16-fold, suggesting participation of efflux in ER resistance. Plasmid mediated quinolone resistance genes qnr were not detected in these isolates. In conclusion, enrofloxacin resistance of A. pleuropneumoniae may be linked to multiple target gene mutations and active effluxs. Enrofloxacin (ER) resistant Actinobacillus pleuropneumoniae strains emerged in Taiwan in 2002. The mechanism of ER resistance in A. pleuropneumoniae has not yet been reported. A total of 48 A. pleuropneumoniae isolates were obtained from the lungs of pigs with pleuropneumonia in Taiwan between September 2007 and April 2008. Twenty-nine isolates were found to be resistant to enrofloxacin. To understand the mechanisms of A. pleuropneumoniae's resistance to ER, enrofloxacin susceptibility of the isolates along with the mutations of the quinolone resistance-determining region (QRDR) of DNA gyrase and topoisomerase IV, qnr genes were analyzed. Enrofloxacin resistant isolates were found to carry at least one mutation in the QRDR of gyrA, leading to amino acid changes at codon 83 or 87. Efflux pump inhibitor (Phe-Arg-b-naphthylamide) decreased enrofloxacin minimum inhibitory concentration 2-16-fold, suggesting participation of efflux in ER resistance. Plasmid mediated quinolone resistance genes qnr were not detected in these isolates. In conclusion, enrofloxacin resistance of A. pleuropneumoniae may be linked to multiple target gene mutations and active effluxs. Enrofloxacin (ER) resistant Actinobacillus pleuropneumoniae strains emerged in Taiwan in 2002. The mechanism of ER resistance in A. pleuropneumoniae has not yet been reported. A total of 48 A. pleuropneumoniae isolates were obtained from the lungs of pigs with pleuropneumonia in Taiwan between September 2007 and April 2008. Twenty-nine isolates were found to be resistant to enrofloxacin. To understand the mechanisms of A. pleuropneumoniae's resistance to ER, enrofloxacin susceptibility of the isolates along with the mutations of the quinolone resistance-determining region (QRDR) of DNA gyrase and topoisomerase IV, qnr genes were analyzed. Enrofloxacin resistant isolates were found to carry at least one mutation in the QRDR of gyrA, leading to amino acid changes at codon 83 or 87. Efflux pump inhibitor (Phe-Arg-beta-naphthylamide) decreased enrofloxacin minimum inhibitory concentration 2-16-fold, suggesting participation of efflux in ER resistance. Plasmid mediated quinolone resistance genes qnr were not detected in these isolates. In conclusion, enrofloxacin resistance of A. pleuropneumoniae may be linked to multiple target gene mutations and active effluxs. Enrofloxacin (ER) resistant Actinobacillus pleuropneumoniae strains emerged in Taiwan in 2002. The mechanism of ER resistance in A. pleuropneumoniae has not yet been reported. A total of 48 A. pleuropneumoniae isolates were obtained from the lungs of pigs with pleuropneumonia in Taiwan between September 2007 and April 2008. Twenty-nine isolates were found to be resistant to enrofloxacin. To understand the mechanisms of A. pleuropneumoniae's resistance to ER, enrofloxacin susceptibility of the isolates along with the mutations of the quinolone resistance-determining region (QRDR) of DNA gyrase and topoisomerase IV, qnr genes were analyzed. Enrofloxacin resistant isolates were found to carry at least one mutation in the QRDR of gyrA, leading to amino acid changes at codon 83 or 87. Efflux pump inhibitor (Phe-Arg-beta-naphthylamide) decreased enrofloxacin minimum inhibitory concentration 2-16-fold, suggesting participation of efflux in ER resistance. Plasmid mediated quinolone resistance genes qnr were not detected in these isolates. In conclusion, enrofloxacin resistance of A. pleuropneumoniae may be linked to multiple target gene mutations and active effluxs.Enrofloxacin (ER) resistant Actinobacillus pleuropneumoniae strains emerged in Taiwan in 2002. The mechanism of ER resistance in A. pleuropneumoniae has not yet been reported. A total of 48 A. pleuropneumoniae isolates were obtained from the lungs of pigs with pleuropneumonia in Taiwan between September 2007 and April 2008. Twenty-nine isolates were found to be resistant to enrofloxacin. To understand the mechanisms of A. pleuropneumoniae's resistance to ER, enrofloxacin susceptibility of the isolates along with the mutations of the quinolone resistance-determining region (QRDR) of DNA gyrase and topoisomerase IV, qnr genes were analyzed. Enrofloxacin resistant isolates were found to carry at least one mutation in the QRDR of gyrA, leading to amino acid changes at codon 83 or 87. Efflux pump inhibitor (Phe-Arg-beta-naphthylamide) decreased enrofloxacin minimum inhibitory concentration 2-16-fold, suggesting participation of efflux in ER resistance. Plasmid mediated quinolone resistance genes qnr were not detected in these isolates. In conclusion, enrofloxacin resistance of A. pleuropneumoniae may be linked to multiple target gene mutations and active effluxs. |
| Author | Lin, Wen-Hsin Wang, Yu-Chih Chan, Jacky Peng-Wen Yeh, Kuang-Sheng Chen, Ter-Hsin Chang, Yi-Chih Chang, Chao-Chin Hsieh, Yi-Mei Lai, Tan-Chen Hsuan, Shih-Ling |
| Author_xml | – sequence: 1 givenname: Yu-Chih surname: Wang fullname: Wang, Yu-Chih organization: Department of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan – sequence: 2 givenname: Jacky Peng-Wen surname: Chan fullname: Chan, Jacky Peng-Wen organization: Department of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan – sequence: 3 givenname: Kuang-Sheng surname: Yeh fullname: Yeh, Kuang-Sheng organization: Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan – sequence: 4 givenname: Chao-Chin surname: Chang fullname: Chang, Chao-Chin organization: The Graduate Institute of Veterinary Public Health, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan – sequence: 5 givenname: Shih-Ling surname: Hsuan fullname: Hsuan, Shih-Ling organization: Graduate Institute of Veterinary Pathobiology, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan – sequence: 6 givenname: Yi-Mei surname: Hsieh fullname: Hsieh, Yi-Mei organization: The Graduate Institute of Veterinary Public Health, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan – sequence: 7 givenname: Yi-Chih surname: Chang fullname: Chang, Yi-Chih organization: Department of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan – sequence: 8 givenname: Tan-Chen surname: Lai fullname: Lai, Tan-Chen organization: Department of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan – sequence: 9 givenname: Wen-Hsin surname: Lin fullname: Lin, Wen-Hsin organization: School of Pharmacy, China Medical University, Taichung, Taiwan – sequence: 10 givenname: Ter-Hsin surname: Chen fullname: Chen, Ter-Hsin email: thc@dragon.nchu.edu.tw organization: The Graduate Institute of Veterinary Public Health, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan |
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| Cites_doi | 10.1016/S1286-4579(01)01534-9 10.1128/AAC.40.4.879 10.1128/JCM.41.9.4095-4100.2003 10.1016/j.vetmic.2008.05.009 10.1128/AAC.00339-07 10.1016/S0378-1135(01)00459-X 10.1016/S0378-1135(00)00206-6 10.1016/j.vetmic.2005.12.014 10.1073/pnas.92.25.11801 10.1186/BF03548158 10.1128/JCM.42.9.4344-4348.2004 10.1128/AAC.00886-08 10.1016/j.ijantimicag.2005.02.006 10.1089/mdr.2005.11.248 10.1093/jac/dkn487 10.1093/jac/dkn111 10.1128/AAC.45.3.990-991.2001 10.1016/S1369-5274(99)00008-9 10.1186/1751-0147-50-19 10.1086/505397 |
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| Keywords | Enrofloxacin resistance Quinolone resistance-determining region Actinobacillus pleuropneumoniae Efflux pump Enrofloxacin Pasteurellaceae Resistance Fluoroquinolone derivatives Bacteria Isolate Antibacterial agent Veterinary Quinolone derivatives |
| Language | English |
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| Title | Molecular characterization of enrofloxacin resistant Actinobacillus pleuropneumoniae isolates |
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