IL-6 and PD-L1 blockade combination inhibits hepatocellular carcinoma cancer development in mouse model

• Published in: Biochemical and biophysical research communications Vol. 486; no. 2; pp. 239 - 244
• Main Authors: Liu, Hu, Shen, Jun, Lu, Kai
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 29.04.2017
• Subjects: animal models; Animals; Antibodies, Neoplasm - pharmacology; Antibodies, Neutralizing - pharmacology; Antineoplastic Combined Chemotherapy Protocols; B7-H1 Antigen - antagonists & inhibitors; B7-H1 Antigen - genetics; B7-H1 Antigen - immunology; Cancer-Associated Fibroblasts - drug effects; Cancer-Associated Fibroblasts - immunology; Cancer-Associated Fibroblasts - pathology; carcinogenesis; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - immunology; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - therapy; Cell Line, Tumor; clinical trials; Combinational therapy; Disease Models, Animal; Drug resistance; Drug Resistance, Neoplasm - drug effects; Drug Synergism; fibroblasts; Gene Expression Regulation, Neoplastic; Hepatocellular carcinoma; hepatoma; Humans; IL-6; Immune checkpoint blockades; immune response; Immunology; immunomodulators; immunosuppression; Injections, Subcutaneous; interleukin-6; Interleukin-6 - antagonists & inhibitors; Interleukin-6 - genetics; Interleukin-6 - immunology; Liver Neoplasms - genetics; Liver Neoplasms - immunology; Liver Neoplasms - pathology; Liver Neoplasms - therapy; Male; Mice; Mice, Inbred BALB C; Molecular Targeted Therapy; neoplasm cells; Signal Transduction; T-lymphocytes; therapeutics; Tumor Microenvironment - drug effects; Immune checkpoint blockades; Hepatocellular carcinoma; Immunology; Drug resistance; Combinational therapy; IL-6

Limited efficacy of immune checkpoint inhibitors in hepatocellular carcinoma (HCC) was observed in clinical trials, thus prompting investigation into combination therapy. Interleukin-6 (IL-6) has important roles in modeling immune responses in cancers. Here, we hypothesized that IL-6 blockade would...