Hepatic stellate cells as key target in liver fibrosis
Progressive liver fibrosis, induced by chronic viral and metabolic disorders, leads to more than one million deaths annually via development of cirrhosis, although no antifibrotic therapy has been approved to date. Transdifferentiation (or “activation”) of hepatic stellate cells is the major cellula...
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| Published in | Advanced drug delivery reviews Vol. 121; pp. 27 - 42 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.11.2017
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Progressive liver fibrosis, induced by chronic viral and metabolic disorders, leads to more than one million deaths annually via development of cirrhosis, although no antifibrotic therapy has been approved to date. Transdifferentiation (or “activation”) of hepatic stellate cells is the major cellular source of matrix protein-secreting myofibroblasts, the major driver of liver fibrogenesis. Paracrine signals from injured epithelial cells, fibrotic tissue microenvironment, immune and systemic metabolic dysregulation, enteric dysbiosis, and hepatitis viral products can directly or indirectly induce stellate cell activation. Dysregulated intracellular signaling, epigenetic changes, and cellular stress response represent candidate targets to deactivate stellate cells by inducing reversion to inactivated state, cellular senescence, apoptosis, and/or clearance by immune cells. Cell type- and target-specific pharmacological intervention to therapeutically induce the deactivation will enable more effective and less toxic precision antifibrotic therapies.
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| AbstractList | Progressive liver fibrosis, induced by chronic viral and metabolic disorders, leads to more than one million deaths annually via development of cirrhosis, although no antifibrotic therapy has been approved to date. Transdifferentiation (or "activation") of hepatic stellate cells is the major cellular source of matrix protein-secreting myofibroblasts, the major driver of liver fibrogenesis. Paracrine signals from injured epithelial cells, fibrotic tissue microenvironment, immune and systemic metabolic dysregulation, enteric dysbiosis, and hepatitis viral products can directly or indirectly induce stellate cell activation. Dysregulated intracellular signaling, epigenetic changes, and cellular stress response represent candidate targets to deactivate stellate cells by inducing reversion to inactivated state, cellular senescence, apoptosis, and/or clearance by immune cells. Cell type- and target-specific pharmacological intervention to therapeutically induce the deactivation will enable more effective and less toxic precision antifibrotic therapies. Progressive liver fibrosis, induced by chronic viral and metabolic disorders, leads to more than one million deaths annually via development of cirrhosis, although no antifibrotic therapy has been approved to date. Transdifferentiation (or “activation”) of hepatic stellate cells is the major cellular source of matrix protein-secreting myofibroblasts, the major driver of liver fibrogenesis. Paracrine signals from injured epithelial cells, fibrotic tissue microenvironment, immune and systemic metabolic dysregulation, enteric dysbiosis, and hepatitis viral products can directly or indirectly induce stellate cell activation. Dysregulated intracellular signaling, epigenetic changes, and cellular stress response represent candidate targets to deactivate stellate cells by inducing reversion to inactivated state, cellular senescence, apoptosis, and/or clearance by immune cells. Cell type- and target-specific pharmacological intervention to therapeutically induce the deactivation will enable more effective and less toxic precision antifibrotic therapies. [Display omitted] |
| Author | Higashi, Takaaki Hoshida, Yujin Friedman, Scott L. |
| AuthorAffiliation | 2 Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan 1 Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Division of Liver Diseases, Department of Medicine, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, USA |
| AuthorAffiliation_xml | – name: 1 Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Division of Liver Diseases, Department of Medicine, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, USA – name: 2 Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan |
| Author_xml | – sequence: 1 givenname: Takaaki surname: Higashi fullname: Higashi, Takaaki organization: Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Division of Liver Diseases, Department of Medicine, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, USA – sequence: 2 givenname: Scott L. surname: Friedman fullname: Friedman, Scott L. organization: Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Division of Liver Diseases, Department of Medicine, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, USA – sequence: 3 givenname: Yujin surname: Hoshida fullname: Hoshida, Yujin email: yujin.hoshida@mssm.edu organization: Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Division of Liver Diseases, Department of Medicine, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28506744$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Alcoholic liver disease Cirrhosis Hepatitis Myofibroblast Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis |
| Title | Hepatic stellate cells as key target in liver fibrosis |
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