Lipid–Polymer Hybrids Encapsulating Iron-Oxide Nanoparticles as a Label for Lateral Flow Immunoassays

The feasibility of using Superparamagnetic Iron Oxide Nanoparticles (SPIONs) encapsulated by lipid–polymer nanoparticles as labels in lateral flow immunoassays (LFIA) was studied. First, nanoparticles were synthesized with average diameters between 4 and 7 (nm) through precipitation in W/O microemul...

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Published inBiosensors (Basel) Vol. 11; no. 7; p. 218
Main Authors Bazsefidpar, Shayesteh, Moyano, Amanda, Gutiérrez, Gemma, Matos, María, Blanco-López, María Carmen
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.07.2021
MDPI
Subjects
Biotin
Carbodiimide
COVID-19
Encapsulation
Ethanol
Hybrids
Immunoassay
Immunoassays
Iron oxides
Labels
lateral flow immunoassays (LFIA)
lipid
Lipids
lipid–polymer hybrid nanoparticles
Microemulsions
Nanoparticles
PLGA
Polymers
Polyvinyl alcohol
Solvents
SPIONs
Surfactants
United States > US
Germany
Spain
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Abstract The feasibility of using Superparamagnetic Iron Oxide Nanoparticles (SPIONs) encapsulated by lipid–polymer nanoparticles as labels in lateral flow immunoassays (LFIA) was studied. First, nanoparticles were synthesized with average diameters between 4 and 7 (nm) through precipitation in W/O microemulsion and further encapsulated using lipid–polymer nanoparticles. Systems formulated were characterized in terms of size and shape by DLS (Nanozetasizer from Malvern) and TEM. After encapsulation, the average size was around (≈20 and 50 nm). These controlled size agglomerates were tested as labels with a model system based on the biotin–neutravidin interaction. For this purpose, the encapsulated nanoparticles were conjugated to neutravidin using the carbodiimide chemistry, and the LFIA was carried out with a biotin test line. The encapsulated SPIONs showed that they could be promising candidates as labels in LFIA test. They would be useful for immunomagnetic separations, that could improve the limits of detection by means of preconcentration.
AbstractList The feasibility of using Superparamagnetic Iron Oxide Nanoparticles (SPIONs) encapsulated by lipid–polymer nanoparticles as labels in lateral flow immunoassays (LFIA) was studied. First, nanoparticles were synthesized with average diameters between 4 and 7 (nm) through precipitation in W/O microemulsion and further encapsulated using lipid–polymer nanoparticles. Systems formulated were characterized in terms of size and shape by DLS (Nanozetasizer from Malvern) and TEM. After encapsulation, the average size was around (≈20 and 50 nm). These controlled size agglomerates were tested as labels with a model system based on the biotin–neutravidin interaction. For this purpose, the encapsulated nanoparticles were conjugated to neutravidin using the carbodiimide chemistry, and the LFIA was carried out with a biotin test line. The encapsulated SPIONs showed that they could be promising candidates as labels in LFIA test. They would be useful for immunomagnetic separations, that could improve the limits of detection by means of preconcentration.
Author Bazsefidpar, Shayesteh
Matos, María
Gutiérrez, Gemma
Moyano, Amanda
Blanco-López, María Carmen
AuthorAffiliation 1 Department of Physical and Analytical Chemistry & Institute of Biotechnology of Asturias, University of Oviedo, c/Julián Clavería 8, 33006 Oviedo, Spain; bazsefidparshayesteh@uniovi.es (S.B.); moyanoamanda@uniovi.es (A.M.)
2 Department of Chemical and Environmental Engineering & Institute of Biotechnology of Asturias, University of Oviedo, 33006 Oviedo, Spain; gutierrezgemma@uniovi.es
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CitedBy_id crossref_primary_10_3390_bios13050567
crossref_primary_10_1016_j_molliq_2024_124215
Cites_doi 10.1016/j.ymeth.2017.02.002
10.1021/acsanm.7b00025
10.1166/jnn.2019.16931
10.1038/s41598-018-30802-1
10.3390/ijms22010427
10.1016/j.bios.2019.04.043
10.3390/bios11040110
10.3390/diagnostics10050288
10.2147/IJN.S198353
10.2147/NSA.S99986
10.1186/s40824-016-0081-3
10.3390/bios10080080
10.3390/ijms16048070
10.1021/acs.analchem.0c00784
10.1039/c3an01321a
10.1039/C6LC01577H
10.1016/j.jconrel.2012.01.043
10.1016/j.jmst.2020.06.003
10.1016/j.jscs.2014.09.001
10.1016/j.trac.2018.07.010
10.1016/B978-0-12-813855-7.00006-4
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References Guo (ref_6) 2021; 60
Zia (ref_12) 2016; 9
Yamada (ref_9) 2017; 17
Bose (ref_18) 2016; 20
Estelrich (ref_11) 2015; 16
ref_21
ref_20
Salvador (ref_14) 2019; 19
Danhier (ref_19) 2012; 161
Xianyu (ref_1) 2018; 106
Farhanian (ref_15) 2018; 8
Sajid (ref_5) 2015; 19
Liu (ref_3) 2019; 136
Hu (ref_10) 2013; 138
Connolly (ref_2) 2017; 116
ref_16
Mukherjee (ref_17) 2019; 14
Chen (ref_8) 2020; 92
Haley (ref_22) 2017; 176
ref_4
ref_7
Ha (ref_13) 2018; 1
References_xml – volume: 116
  start-page: 132
  year: 2017
  ident: ref_2
  article-title: Magnetic lateral flow immunoassay test strip development—Considerations for proof of concept evaluation
  publication-title: Methods
  doi: 10.1016/j.ymeth.2017.02.002
  contributor:
    fullname: Connolly
– volume: 1
  start-page: 512
  year: 2018
  ident: ref_13
  article-title: Recent Advances Incorporating Superparamagnetic Nanoparticles into Immunoassays
  publication-title: ACS Appl. Nano Mater.
  doi: 10.1021/acsanm.7b00025
  contributor:
    fullname: Ha
– volume: 19
  start-page: 4839
  year: 2019
  ident: ref_14
  article-title: Synthesis of Superparamagnetic Iron Oxide Nanoparticles: SWOT Analysis Towards Their Conjugation to Biomolecules for Molecular Recognition Applications
  publication-title: J. Nanosci. Nanotechnol.
  doi: 10.1166/jnn.2019.16931
  contributor:
    fullname: Salvador
– volume: 8
  start-page: 1
  year: 2018
  ident: ref_15
  article-title: Large-Scale Encapsulation of Magnetic Iron Oxide Nanoparticles via Syngas Photo-Initiated Chemical Vapor Deposition
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-30802-1
  contributor:
    fullname: Farhanian
– ident: ref_20
  doi: 10.3390/ijms22010427
– volume: 136
  start-page: 60
  year: 2019
  ident: ref_3
  article-title: Signal amplification strategies for paper-based analytical devices
  publication-title: Biosens. Bioelectron.
  doi: 10.1016/j.bios.2019.04.043
  contributor:
    fullname: Liu
– ident: ref_4
  doi: 10.3390/bios11040110
– ident: ref_7
  doi: 10.3390/diagnostics10050288
– volume: 14
  start-page: 1937
  year: 2019
  ident: ref_17
  article-title: Lipid—Polymer hybrid nanoparticles as a next- generation drug delivery platform: State of the art, emerging technologies, and perspectives
  publication-title: Int. J. Nanomed.
  doi: 10.2147/IJN.S198353
  contributor:
    fullname: Mukherjee
– volume: 9
  start-page: 49
  year: 2016
  ident: ref_12
  article-title: Synthesis, characterization, applications, and challenges of iron oxide nanoparticles
  publication-title: Nanotechnol. Sci. Appl.
  doi: 10.2147/NSA.S99986
  contributor:
    fullname: Zia
– volume: 20
  start-page: 1
  year: 2016
  ident: ref_18
  article-title: Lipid-based surface engineering of PLGA nanoparticles for drug and gene delivery applications
  publication-title: Biomater. Res.
  doi: 10.1186/s40824-016-0081-3
  contributor:
    fullname: Bose
– ident: ref_21
  doi: 10.3390/bios10080080
– volume: 16
  start-page: 8070
  year: 2015
  ident: ref_11
  article-title: Iron oxide nanoparticles for magnetically-guided and magnetically-responsive drug delivery
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms16048070
  contributor:
    fullname: Estelrich
– volume: 92
  start-page: 7226
  year: 2020
  ident: ref_8
  article-title: Rapid and Sensitive Detection of anti-SARS-CoV-2 IgG, Using Lanthanide-Doped Nanoparticles-Based Lateral Flow Immunoassay
  publication-title: Anal. Chem.
  doi: 10.1021/acs.analchem.0c00784
  contributor:
    fullname: Chen
– volume: 176
  start-page: 139
  year: 2017
  ident: ref_22
  article-title: The Principles and Applications of Avidin-Based Nanoparticles in Drug Delivery and Diagnosis
  publication-title: Physiol. Behav.
  contributor:
    fullname: Haley
– volume: 138
  start-page: 6709
  year: 2013
  ident: ref_10
  article-title: Nanoparticle-based signal generation and amplification in microfluidic devices for bioanalysis
  publication-title: Analyst
  doi: 10.1039/c3an01321a
  contributor:
    fullname: Hu
– volume: 17
  start-page: 1206
  year: 2017
  ident: ref_9
  article-title: Toward practical application of paper-based microfluidics for medical diagnostics: State-of-the-art and challenges
  publication-title: Lab Chip
  doi: 10.1039/C6LC01577H
  contributor:
    fullname: Yamada
– volume: 161
  start-page: 505
  year: 2012
  ident: ref_19
  article-title: PLGA-based nanoparticles: An overview of biomedical applications
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2012.01.043
  contributor:
    fullname: Danhier
– volume: 60
  start-page: 90
  year: 2021
  ident: ref_6
  article-title: Nanomaterial Labels in Lateral Flow Immunoassays for Point-of-Care-Testing
  publication-title: J. Mater. Sci. Technol.
  doi: 10.1016/j.jmst.2020.06.003
  contributor:
    fullname: Guo
– volume: 19
  start-page: 689
  year: 2015
  ident: ref_5
  article-title: Designs, formats and applications of lateral flow assay: A literature review
  publication-title: J. Saudi Chem. Soc.
  doi: 10.1016/j.jscs.2014.09.001
  contributor:
    fullname: Sajid
– volume: 106
  start-page: 213
  year: 2018
  ident: ref_1
  article-title: Magnetic particles-enabled biosensors for point-of-care testing
  publication-title: TrAC Trends Anal. Chem.
  doi: 10.1016/j.trac.2018.07.010
  contributor:
    fullname: Xianyu
– ident: ref_16
  doi: 10.1016/B978-0-12-813855-7.00006-4
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SubjectTerms Biotin
Carbodiimide
COVID-19
Encapsulation
Ethanol
Hybrids
Immunoassay
Immunoassays
Iron oxides
Labels
lateral flow immunoassays (LFIA)
lipid
Lipids
lipid–polymer hybrid nanoparticles
Microemulsions
Nanoparticles
PLGA
Polymers
Polyvinyl alcohol
Solvents
SPIONs
Surfactants
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Title Lipid–Polymer Hybrids Encapsulating Iron-Oxide Nanoparticles as a Label for Lateral Flow Immunoassays
URI https://www.proquest.com/docview/2554441738
https://search.proquest.com/docview/2559430802
https://pubmed.ncbi.nlm.nih.gov/PMC8301895
https://doaj.org/article/f64c1412681c415e84b5fc869bd45634
Volume 11
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