Multimerization of Zika Virus-NS5 Causes Ciliopathy and Forces Premature Neurogenesis

• Published in: Cell stem cell Vol. 27; no. 6; pp. 920 - 936.e8
• Main Authors: Saade, Murielle, Ferrero, Diego S., Blanco-Ameijeiras, José, Gonzalez-Gobartt, Elena, Flores-Mendez, Marco, Ruiz-Arroyo, Victor M., Martínez-Sáez, Elena, Ramón y Cajal, Santiago, Akizu, Naiara, Verdaguer, Nuria, Martí, Elisa
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.12.2020
• Subjects: centrosome; ciliopathy; CNS growth; microcephaly; neural progenitor cell; Zika virus; microcephaly; Zika virus; centrosome; neural progenitor cell; CNS growth; ciliopathy

Zika virus (ZikV) is a flavivirus that infects neural tissues, causing congenital microcephaly. ZikV has evolved multiple mechanisms to restrict proliferation and enhance cell death, although the underlying cellular events involved remain unclear. Here we show that the ZikV-NS5 protein interacts wit...