The alteration of hypoxia inducible factor-1 (HIF-1) and its target genes in mood disorder patients

• Published in: Progress in neuro-psychopharmacology & biological psychiatry Vol. 43; pp. 222 - 229
• Main Authors: Shibata, Tomohiko, Yamagata, Hirotaka, Uchida, Shusaku, Otsuki, Koji, Hobara, Teruyuki, Higuchi, Fumihiro, Abe, Naoko, Watanabe, Yoshifumi
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 03.06.2013; Elsevier
• Subjects: Antidepressive Agents - therapeutic use; Aryl Hydrocarbon Receptor Nuclear Translocator - biosynthesis; Aryl Hydrocarbon Receptor Nuclear Translocator - genetics; Biological and medical sciences; Bipolar Disorder - blood; Bipolar Disorder - genetics; Depressive Disorder, Major - blood; Depressive Disorder, Major - genetics; Diagnostic and Statistical Manual of Mental Disorders; DNA, Complementary - biosynthesis; DNA, Complementary - genetics; Female; Gene expression; Gene Expression - drug effects; HIF-1; Humans; Hypoxia-Inducible Factor 1 - blood; Hypoxia-Inducible Factor 1 - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Leukocyte; Leukocytes - metabolism; Male; Medical sciences; Middle Aged; Mood disorder; Mood Disorders - genetics; Mood Disorders - psychology; Neuropharmacology; Pharmacology. Drug treatments; Psychiatric Status Rating Scales; Real-Time Polymerase Chain Reaction; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; VEGF; DSM-IV; PFKFB3; EPO; Leukocyte; VPA; Q-PCR; MDD; HIF-1; LDHA; PGK1; CBZ; HDRS; Li; Mood disorder; BDNF; VEGF; BNip3; ARNT; AhR; GLUT1,3; IGF-2; Gene expression; SSRI; GDNF; SNRI; BPD; Human; Target; Vascular endothelium growth factor; Targeting; Gene; Genetics; Transcription factor HIF1

Recent studies suggest that the dysfunction of neural plasticity is associated with mood disorders. Hypoxia-inducible factor-1 (HIF-1), which is a transcriptional activator of vascular endothelial growth factor (VEGF), activates the cellular response to hypoxia. HIF-1 is ubiquitously expressed in al...