Genetic and epigenetic aberrations of ABCB1 synergistically boost the acquisition of taxane resistance in esophageal squamous cancer cells

• Published in: Biochemical and biophysical research communications Vol. 526; no. 3; pp. 586 - 591
• Main Authors: Sumarpo, Anton, Ito, Kazuma, Saiki, Yuriko, Ishizawa, Kota, Wang, Ruobing, Chen, Na, Sunamura, Makoto, Horii, Akira
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.06.2020
• Subjects: ABCB1; Antineoplastic Agents - pharmacology; ATP Binding Cassette Transporter, Subfamily B - genetics; Bridged-Ring Compounds - pharmacology; Cell Line, Tumor; cell lines; Drug Resistance, Neoplasm; drug therapy; Epigenesis, Genetic - drug effects; Epigenetics; esophageal neoplasms; Esophageal Neoplasms - drug therapy; Esophageal Neoplasms - genetics; Esophageal squamous cell carcinoma; Esophageal Squamous Cell Carcinoma - drug therapy; Esophageal Squamous Cell Carcinoma - genetics; Gene amplification; Gene Amplification - drug effects; gene expression; Gene Expression Regulation, Neoplastic - drug effects; Humans; methylation; neoplasm cells; Taxane resistance; taxanes; Taxoids - pharmacology; Epigenetics; Taxane resistance; Esophageal squamous cell carcinoma; Gene amplification; ABCB1

Taxanes are applied as potent chemotherapeutic agents in the treatment of patients with esophageal cancer, but their usefulness is limited, partly because of acquisition of chemoresistance. In our previous study, we established three taxane resistant esophageal cancer cell lines; significant ABCB1 u...