Pharmacodynamics of Orally Administered Sustained- release Hydromorphone in Humans

• Published in: Anesthesiology (Philadelphia) Vol. 94; no. 1; pp. 63 - 73
• Main Authors: Angst, Martin S., Drover, David R., Lötsch, Jörn, Ramaswamy, Bhamini, Naidu, Sujata, Wada, D. Russell, Stanski, Donald R.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott 01.01.2001
• Subjects: Administration, Oral; Adult; Analgesia; Analgesics; Analgesics, Opioid - administration & dosage; Analgesics, Opioid - blood; Analgesics, Opioid - pharmacokinetics; Analgesics, Opioid - pharmacology; Biological and medical sciences; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Hydromorphone - administration & dosage; Hydromorphone - blood; Hydromorphone - pharmacokinetics; Hydromorphone - pharmacology; Linear Models; Male; Medical sciences; Neuropharmacology; Pain Measurement; Pain Threshold - drug effects; Pharmacology. Drug treatments; Human; Morphinan derivatives; Pharmacokinetic pharmacodynamic relationship; Controlled release form; Single dose; Oral administration; Narcotic analgesic; Hydromorphone; Analgesia; Chemotherapy; Pain; Treatment; Activity concentration relation; Immediate release form; Dosage form; Pharmacokinetics; Osmotic pump; Comparative study

The disposition kinetics of hydromorphone generally necessitates oral administration every 4 h of the conventional immediate-release tablet to provide sustained pain relief. This trial examined time course and magnitude of analgesia to experimental pain after administration of sustained-release hydr...