Pharmacodynamics of Orally Administered Sustained- release Hydromorphone in Humans - Angst, Martin S.; Drover, David R.; Lötsch, Jörn; Ramaswamy, Bhamini; Naidu, Sujata; Wada, D. Russell; Stanski, Donald R. (Anesthesiology (Philadelphia), 2001)
Keywords: Administration, Oral; Adult; Analgesia; Analgesics; Analgesics, Opioid - administration & dosage; Analgesics, Opioid - blood; Analgesics, Opioid - pharmacokinetics; Analgesics, Opioid - pharmacology; Biological and medical sciences; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Hydromorphone - administration & dosage; Hydromorphone - blood; Hydromorphone - pharmacokinetics; Hydromorphone - pharmacology; Linear Models; Male; Medical sciences; Neuropharmacology; Pain Measurement; Pain Threshold - drug effects; Pharmacology. Drug treatments; Human; Morphinan derivatives; Pharmacokinetic pharmacodynamic relationship; Controlled release form; Single dose; Oral administration; Narcotic analgesic; Hydromorphone; Analgesia; Chemotherapy; Pain; Treatment; Activity concentration relation; Immediate release form; Dosage form; Pharmacokinetics; Osmotic pump; Comparative study