Cellular Pharmacokinetic Model-Based Analysis of Genistein, Glyceollin, and MK-571 Effects on 5 (and 6)-Carboxy-2′,7′-Dichloroflourescein Disposition in Caco-2 Cells

• Published in: Journal of pharmaceutical sciences Vol. 107; no. 4; pp. 1194 - 1203
• Main Authors: Drennen, Callie, Gorse, Erin, Stratford, Robert E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2018
• Subjects: active transport; Biological Transport - physiology; Caco-2 Cells; Cell Line, Tumor; drug transport; efflux pumps; Fluoresceins - metabolism; Genistein - pharmacokinetics; Humans; intestinal secretion/transport; membrane transport; Membrane Transport Proteins - metabolism; Multidrug Resistance-Associated Proteins - metabolism; pharmacokinetics; Propionates - pharmacokinetics; Pterocarpans - pharmacokinetics; Quinolines - pharmacokinetics; transcellular transport; transporters; ABCC3; BCRP; AB; Caco-2 cells; ABCC2; transporters; CDF; active transport; drug transport; Cl; MRP; intestinal secretion/transport; transcellular transport; CDFDA; pharmacokinetics; membrane transport; efflux pumps; BA

Pharmacokinetic modeling was used to describe 5 (and 6)-carboxy-2′,7′-dichloroflourescein (CDF) disposition in Caco-2 cells following CDF or CDFDA (CDF diacetate) dosing. CDF transcellular flux was modeled by simple passive diffusion. CDFDA dosing models were based on simultaneous fitting of CDF lev...