Effect of Aromatase Inhibitor Therapy on Sleep and Activity Patterns in Early-stage Breast Cancer

• Published in: Clinical breast cancer Vol. 18; no. 2; pp. 168 - 174.e2
• Main Authors: Bhave, Manali A., Speth, Kelly A., Kidwell, Kelley M., Lyden, Angela, Alsamarraie, Cindy, Murphy, Susan L., Henry, N. Lynn
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2018
• Subjects: Actigraphy; Adjuvant endocrine therapy; Aged; Aged, 80 and over; AIs; Antineoplastic Agents, Hormonal - adverse effects; Aromatase Inhibitors - adverse effects; Breast - pathology; Breast - surgery; Breast Neoplasms - pathology; Breast Neoplasms - therapy; Chemotherapy, Adjuvant - adverse effects; Chemotherapy, Adjuvant - methods; Fatigue - chemically induced; Fatigue - diagnosis; Female; Humans; Mastectomy; Medication Adherence; Middle Aged; Musculoskeletal Pain - chemically induced; Musculoskeletal Pain - diagnosis; Pain Measurement; Patient Reported Outcome Measures; Patient-reported outcomes; Pilot Projects; Postmenopause; Prospective Studies; Receptors, Estrogen; Receptors, Progesterone; Sleep Wake Disorders - chemically induced; Sleep Wake Disorders - diagnosis; Treatment discontinuation; Treatment Outcome; Actigraphy; Treatment discontinuation; AIs; Patient-reported outcomes; Adjuvant endocrine therapy

Treatment-emergent side effects often affect adherence to aromatase inhibitor (AI) therapy. In the present study, we examined the sleep patterns and daytime function both objectively using actigraphy and subjectively using validated questionnaires in women receiving AI therapy. Daytime function sign...