M2 tumor‑associated macrophages promote tumor progression in non‑small‑cell lung cancer

• Published in: Experimental and therapeutic medicine Vol. 18; no. 6; pp. 4490 - 4498
• Main Authors: Sumitomo, Ryota, Hirai, Tatsuya, Fujita, Masaaki, Murakami, Hiroaki, Otake, Yosuke, Huang, Cheng‑Long
• Format: Journal Article
• Language: English
• Published: Athens Spandidos Publications 01.12.2019; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Alectinib; Analysis; C-reactive protein; Cancer metastasis; Cancer therapies; Cancer treatment; Cloning; Cytokines; Immunohistochemistry; Kinases; Lung cancer; Macrophages; Medical prognosis; Medical research; Metastasis; Mutation; Nivolumab; Non-small cell lung cancer; Phenotypes; Studies; Surgery; Thoracic surgery; Tumors; Vascular endothelial growth factor

Tumor-associated macrophages (TAMs) are key components of the tumor microenvironment that can be polarized into different phenotypes, including tumor-inhibiting M1 macrophages and tumor-promoting M2 macrophages. To elucidate the biological and clinical significance of M2 TAMs in non-small-cell lung...