METTL3 inhibits hepatic insulin sensitivity via N6-methyladenosine modification of Fasn mRNA and promoting fatty acid metabolism

• Published in: Biochemical and biophysical research communications Vol. 518; no. 1; pp. 120 - 126
• Main Authors: Xie, Wei, Ma, Lei Lei, Xu, Yue Qing, Wang, Bao Hua, Li, Sai Mei
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 08.10.2019
• Subjects: blood glucose; Dependoparvovirus; Fasn; fatty acid metabolism; fatty acids; fatty-acid synthase; high fat diet; homeostasis; insulin; insulin resistance; liver; methylation; methyltransferases; METTL3; mice; N6-Methyladenosine; noninsulin-dependent diabetes mellitus; Type 2 diabetes; Type 2 diabetes; N6-Methyladenosine; METTL3; Fasn

Type 2 diabetes (T2D) is characterized by lack of insulin, insulin resistance and high blood sugar. However, the underlying mechanisms of insulin resistance during T2D development remains unclear. As the most common mRNAs modification, N6-Methyladenosine (m6A) is involved in many of pathological pro...