Is atypical follicular adenoma of the thyroid a preinvasive malignancy?

• Published in: Human pathology Vol. 34; no. 7; pp. 666 - 669
• Main Authors: Tzen, Chin-Yuan, Huang, Yu-Wen, Fu, Yao-Shi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2003; Elsevier Limited
• Subjects: Adenocarcinoma, Follicular - genetics; Adenocarcinoma, Follicular - pathology; Adenoma - chemistry; Adenoma - genetics; Adenoma - pathology; atypical adenoma of thyroid; Biomarkers, Tumor - analysis; Cancer; Diagnosis, Differential; DNA Mutational Analysis; DNA Primers - chemistry; DNA, Neoplasm - analysis; Genes, p53 - genetics; Humans; Immunohistochemistry; Mutation; p53 mutation; Point Mutation; Polymerase chain reaction; Precancerous Conditions - genetics; Precancerous Conditions - pathology; Thyroid cancer; Thyroid gland; Thyroid Neoplasms - chemistry; Thyroid Neoplasms - genetics; Thyroid Neoplasms - pathology; Tumor Suppressor Protein p53 - chemistry; Tumor Suppressor Protein p53 - genetics; Tumors; p53 mutation; PCR; atypical adenoma of thyroid

Among the follicular neoplasms of the thyroid, the definition and nature of atypical adenoma have been confusing. Despite the original speculation about the biologic behavior of preinvasive malignancies, this term is currently used as an expression of uncertainty. To examine the molecular features o...