Bovine lactoferrin suppresses the cathepsin-dependent pathway of SARS-CoV-2 entry in vitro

• Published in: International dairy journal Vol. 148; p. 105805
• Main Authors: Kobayashi-Sakamoto, Michiyo, Maeda, Toyonobu, Yusa, Junko, Shimada, Takahisa, Tani, Hideki, Kato, Yasumasa, Hirose, Kimiharu
• Format: Journal Article
• Language: English
• Published: 01.01.2024
• Subjects: cattle; COVID-19 infection; glycoproteins; humans; lactoferrin; mutants; peptidyl-dipeptidase A; proteinases; Pseudoviridae; serine; Severe acute respiratory syndrome coronavirus 2; viruses

Severe acute respiratory coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). The frequent appearance of variants requires adjunct strategies to combat SARS-CoV-2 infections. Lactoferrin, a naturally occurring glycoprotein, exhibits promising antiviral properties. Here, we investig...