Structure and Function of a Bacterial Gap Junction Analog

• Published in: Cell Vol. 178; no. 2; pp. 374 - 384.e15
• Main Authors: Weiss, Gregor L., Kieninger, Ann-Katrin, Maldener, Iris, Forchhammer, Karl, Pilhofer, Martin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 11.07.2019; Cell Press
• Subjects: Anabaena - metabolism; Bacterial Proteins - chemistry; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Carbonyl Cyanide m-Chlorophenyl Hydrazone - analogs & derivatives; Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology; Cell Communication - drug effects; cell-cell connections; Cryoelectron Microscopy; cyanobacteria; electron cryotomography; fluorescence recovery after photobleaching; Gap Junctions - chemistry; Gap Junctions - metabolism; Gap Junctions - ultrastructure; Membrane Proteins - chemistry; Membrane Proteins - genetics; Membrane Proteins - metabolism; membrane trafficking; multicellularity; Mutagenesis; septal junctions; subtomogram averaging; multicellularity; cyanobacteria; cell-cell connections; septal junctions; subtomogram averaging; membrane trafficking; electron cryotomography; fluorescence recovery after photobleaching

Multicellular lifestyle requires cell-cell connections. In multicellular cyanobacteria, septal junctions enable molecular exchange between sister cells and are required for cellular differentiation. The structure of septal junctions is poorly understood, and it is unknown whether they are capable of...