Between the Devil and the Deep Blue Sea: Non-Coding RNAs Associated with Transmissible Cancers in Tasmanian Devil, Domestic Dog and Bivalves

Currently there are nine known examples of transmissible cancers in nature. They have been observed in domestic dog, Tasmanian devil, and six bivalve species. These tumours can overcome host immune defences and spread to other members of the same species. Non-coding RNAs (ncRNAs) are known to play r...

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Bibliographic Details
Published inNon-coding RNA Vol. 7; no. 4; p. 72
Main Authors Lister, Nicholas C., Milton, Ashley M., Hanrahan, Benjamin J., Waters, Paul D.
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 10.11.2021
MDPI
Subjects
Antigens
bivalve
Cancer
Concept Paper
CRISPR
CRISPR/Cas
Dogs
Gene expression
Immune system
Immunoglobulins
Mollusks
ncRNAs
Non-coding RNA
Population
Tasmanian devil
Telomerase
transmissible
Transplants & implants
Tumorigenesis
Tumors
Worms
Y chromosomes
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Summary:Currently there are nine known examples of transmissible cancers in nature. They have been observed in domestic dog, Tasmanian devil, and six bivalve species. These tumours can overcome host immune defences and spread to other members of the same species. Non-coding RNAs (ncRNAs) are known to play roles in tumorigenesis and immune system evasion. Despite their potential importance in transmissible cancers, there have been no studies on ncRNA function in this context to date. Here, we present possible applications of the CRISPR/Cas system to study the RNA biology of transmissible cancers. Specifically, we explore how ncRNAs may play a role in the immortality and immune evasion ability of these tumours.
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ISSN:2311-553X
2311-553X
DOI:10.3390/ncrna7040072