S-Sulfhydration of ATP synthase by hydrogen sulfide stimulates mitochondrial bioenergetics

• Published in: Pharmacological research Vol. 113; no. Pt A; pp. 116 - 124
• Main Authors: Módis, Katalin, Ju, YoungJun, Ahmad, Akbar, Untereiner, Ashley A., Altaany, Zaid, Wu, Lingyun, Szabo, Csaba, Wang, Rui
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.11.2016
• Subjects: Adenosine Triphosphate - metabolism; Animals; ATP synthase; Bioenergetics; Burn; Burn injury; Cell Line; Cell Line, Tumor; Cystathionine gamma-Lyase - metabolism; Cysteine; Cysteine - metabolism; Energy Metabolism - physiology; H2S; HEK293 Cells; Hep G2 Cells; Humans; Hydrogen sulfide; Hydrogen Sulfide - metabolism; Liver - metabolism; Liver - physiology; Male; Mice; Mitochondria; Mitochondria - metabolism; Mitochondria - physiology; Mitochondrial Proton-Translocating ATPases - metabolism; Mutagenesis, Site-Directed - methods; Protein Processing, Post-Translational - physiology; S-Sulfhydration; Burn; Hydrogen sulfide; ATP synthase; Cysteine; Mitochondria; Bioenergetics; H2S; S-Sulfhydration; Burn injury; HS

[Display omitted] Mammalian cells can utilize hydrogen sulfide (H2S) to support mitochondrial respiration. The aim of our study was to explore the potential role of S-sulfhydration (a H2S-induced posttranslational modification, also known as S-persulfidation) of the mitochondrial inner membrane prot...