Brain structural correlates of familial risk for mental illness: a meta-analysis of voxel-based morphometry studies in relatives of patients with psychotic or mood disorders

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 45; no. 8; pp. 1369 - 1379
• Main Authors: Zhang, Wenjing, Sweeney, John A., Yao, Li, Li, Siyi, Zeng, Jiaxin, Xu, Mengyuan, Tallman, Maxwell J., Gong, Qiyong, DelBello, Melissa P., Lui, Su, Nery, Fabiano G.
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.07.2020; Springer International Publishing
• Subjects: Bipolar disorder; Brain - diagnostic imaging; Cerebellum; Depressive Disorder, Major - diagnostic imaging; Depressive Disorder, Major - genetics; Families & family life; Frontal gyrus; Gene mapping; Genetic Predisposition to Disease; Gray Matter - diagnostic imaging; Heredity; Humans; Magnetic Resonance Imaging; Mental depression; Mental disorders; Meta-analysis; Mood; Mood Disorders; Morphometry; Neocortex; Neostriatum; Neuroimaging; Schizophrenia; Substantia grisea; Systematic review; Thalamus

Schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD) are heritable psychiatric disorders with partially overlapping genetic liability. Shared and disorder-specific neurobiological abnormalities associated with familial risk for developing mental illnesses are largely unkno...