Perfluorooctanoic acid induces migration and invasion and inhibits apoptosis through the PI3K/AKT signaling pathway in human rhabdomyosarcoma cells

• Published in: Oncology reports Vol. 42; no. 4; pp. 1558 - 1568
• Main Authors: Zhang, Qian, Wang, Jianan, Chen, Chen, Kong, Yi, Yan, Hong, Duan, Jinyan, Wang, Chi, Sha, Yingjiao, Wen, Xinyu, Wang, Chengbin
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.10.2019; Spandidos Publications UK Ltd
• Subjects: Ammonium perfluorooctanoate; Analysis; Apoptosis; Cancer; Cancer metastasis; Cancer research; Cell adhesion & migration; Cell cycle; Cell division; Cell growth; Cyclin-dependent kinases; Experiments; Genes; Kinases; Laboratory animals; Medical prognosis; Metastasis; Motility; Penicillin; Phospholipids; Physiology; Pollutants; Protein expression; Protein kinases; Proteins; Rhabdomyosarcoma; Scientific equipment industry; Studies; Transcription (Genetics); Tumor proteins; Tumorigenesis; Tumors; Wound care; Wound healing; Wounds; United States; China; United States > US

The present study aimed to investigate the effects of perfluorooctanoic acid (PFOA) on tumor cell migration, invasion and apoptosis by activation of the PI3K/AKT signaling pathway in human rhabdomyosarcoma (RMS). PFOA is a persistent, synthetic organic environment pollutant, which has been previousl...