Long noncoding RNA UCA1 promotes chondrogenic differentiation of human bone marrow mesenchymal stem cells via miRNA-145-5p/SMAD5 and miRNA-124-3p/SMAD4 axis

• Published in: Biochemical and biophysical research communications Vol. 514; no. 1; pp. 316 - 322
• Main Authors: Shu, Tao, He, Lei, Wang, Xuan, Pang, Mao, Yang, Bu, Feng, Feng, Wu, Zizhao, Liu, Chang, Zhang, Shufan, Liu, Bin, Wang, Qiyou, Rong, Limin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 18.06.2019
• Subjects: bone marrow; Cell Differentiation - genetics; Chondrogenesis; Chondrogenesis - genetics; Down-Regulation; Humans; Mesenchymal stem cell; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - physiology; mesenchymal stromal cells; MicroRNAs - metabolism; miRNA-124-3p; miRNA-145-5p; non-coding RNA; RNA, Long Noncoding - genetics; SMAD; Smad4 Protein - genetics; Smad4 Protein - metabolism; Smad5 Protein - genetics; Smad5 Protein - metabolism; transforming growth factor beta; UCA1; Mesenchymal stem cell; miRNA-124-3p; UCA1; miRNA-145-5p; SMAD; Chondrogenesis

Long noncoding RNA (lncRNAs) UCA1 has been known to be critical for the chondrogenic differentiation of marrow mesenchymal stem cells (MSCs). In this study, we explore the effects and mechanisms of UCA1 on the promotion of chondrogenesis of MSCs. During the processes of chondrogenic differentiation...