Long noncoding RNA UCA1 promotes chondrogenic differentiation of human bone marrow mesenchymal stem cells via miRNA-145-5p/SMAD5 and miRNA-124-3p/SMAD4 axis
Long noncoding RNA (lncRNAs) UCA1 has been known to be critical for the chondrogenic differentiation of marrow mesenchymal stem cells (MSCs). In this study, we explore the effects and mechanisms of UCA1 on the promotion of chondrogenesis of MSCs. During the processes of chondrogenic differentiation...
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| Published in | Biochemical and biophysical research communications Vol. 514; no. 1; pp. 316 - 322 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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United States
Elsevier Inc
18.06.2019
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| Abstract | Long noncoding RNA (lncRNAs) UCA1 has been known to be critical for the chondrogenic differentiation of marrow mesenchymal stem cells (MSCs). In this study, we explore the effects and mechanisms of UCA1 on the promotion of chondrogenesis of MSCs. During the processes of chondrogenic differentiation of MSCs, UCA1, miRNA-145-5p or miRNA-124-3p was overexpressed into MSCs. UCA1 substantially improved chondrogenesis of MSCs. Furthermore, UCA1 obviously down-regulated the expression of miRNA-145-5p and miRNA-124-3p, which attenuated the chondrogenic differentiation of MSCs. In addition, UCA1 significantly stimulated TGF-β pathway member SMAD5 and SMAD4, which is targeted by miRNA-145-5p and miRNA-124-3p. Collectively, these outcomes suggest that UCA1 enhances chondrogenic differentiation of MSCs via the miRNA-145-5p/SMAD5 and miRNA-124-3p/SMAD4 axis.
•UCA1 promoted the chondrogenic differentiation of MSCs.•UCA1 down-regulated miRNA-145-5p/miRNA-124-3p during this process.•miRNA-145-5p targeted SMAD5 and miRNA-124-3p targeted SMAD4. |
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| AbstractList | Long noncoding RNA (lncRNAs) UCA1 has been known to be critical for the chondrogenic differentiation of marrow mesenchymal stem cells (MSCs). In this study, we explore the effects and mechanisms of UCA1 on the promotion of chondrogenesis of MSCs. During the processes of chondrogenic differentiation of MSCs, UCA1, miRNA-145-5p or miRNA-124-3p was overexpressed into MSCs. UCA1 substantially improved chondrogenesis of MSCs. Furthermore, UCA1 obviously down-regulated the expression of miRNA-145-5p and miRNA-124-3p, which attenuated the chondrogenic differentiation of MSCs. In addition, UCA1 significantly stimulated TGF-β pathway member SMAD5 and SMAD4, which is targeted by miRNA-145-5p and miRNA-124-3p. Collectively, these outcomes suggest that UCA1 enhances chondrogenic differentiation of MSCs via the miRNA-145-5p/SMAD5 and miRNA-124-3p/SMAD4 axis. Long noncoding RNA (lncRNAs) UCA1 has been known to be critical for the chondrogenic differentiation of marrow mesenchymal stem cells (MSCs). In this study, we explore the effects and mechanisms of UCA1 on the promotion of chondrogenesis of MSCs. During the processes of chondrogenic differentiation of MSCs, UCA1, miRNA-145-5p or miRNA-124-3p was overexpressed into MSCs. UCA1 substantially improved chondrogenesis of MSCs. Furthermore, UCA1 obviously down-regulated the expression of miRNA-145-5p and miRNA-124-3p, which attenuated the chondrogenic differentiation of MSCs. In addition, UCA1 significantly stimulated TGF-β pathway member SMAD5 and SMAD4, which is targeted by miRNA-145-5p and miRNA-124-3p. Collectively, these outcomes suggest that UCA1 enhances chondrogenic differentiation of MSCs via the miRNA-145-5p/SMAD5 and miRNA-124-3p/SMAD4 axis.Long noncoding RNA (lncRNAs) UCA1 has been known to be critical for the chondrogenic differentiation of marrow mesenchymal stem cells (MSCs). In this study, we explore the effects and mechanisms of UCA1 on the promotion of chondrogenesis of MSCs. During the processes of chondrogenic differentiation of MSCs, UCA1, miRNA-145-5p or miRNA-124-3p was overexpressed into MSCs. UCA1 substantially improved chondrogenesis of MSCs. Furthermore, UCA1 obviously down-regulated the expression of miRNA-145-5p and miRNA-124-3p, which attenuated the chondrogenic differentiation of MSCs. In addition, UCA1 significantly stimulated TGF-β pathway member SMAD5 and SMAD4, which is targeted by miRNA-145-5p and miRNA-124-3p. Collectively, these outcomes suggest that UCA1 enhances chondrogenic differentiation of MSCs via the miRNA-145-5p/SMAD5 and miRNA-124-3p/SMAD4 axis. Long noncoding RNA (lncRNAs) UCA1 has been known to be critical for the chondrogenic differentiation of marrow mesenchymal stem cells (MSCs). In this study, we explore the effects and mechanisms of UCA1 on the promotion of chondrogenesis of MSCs. During the processes of chondrogenic differentiation of MSCs, UCA1, miRNA-145-5p or miRNA-124-3p was overexpressed into MSCs. UCA1 substantially improved chondrogenesis of MSCs. Furthermore, UCA1 obviously down-regulated the expression of miRNA-145-5p and miRNA-124-3p, which attenuated the chondrogenic differentiation of MSCs. In addition, UCA1 significantly stimulated TGF-β pathway member SMAD5 and SMAD4, which is targeted by miRNA-145-5p and miRNA-124-3p. Collectively, these outcomes suggest that UCA1 enhances chondrogenic differentiation of MSCs via the miRNA-145-5p/SMAD5 and miRNA-124-3p/SMAD4 axis. •UCA1 promoted the chondrogenic differentiation of MSCs.•UCA1 down-regulated miRNA-145-5p/miRNA-124-3p during this process.•miRNA-145-5p targeted SMAD5 and miRNA-124-3p targeted SMAD4. |
| Author | Wu, Zizhao Liu, Bin Wang, Qiyou Shu, Tao Yang, Bu Feng, Feng Wang, Xuan He, Lei Zhang, Shufan Pang, Mao Rong, Limin Liu, Chang |
| Author_xml | – sequence: 1 givenname: Tao surname: Shu fullname: Shu, Tao organization: Department of Spine Surgery, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510630, China – sequence: 2 givenname: Lei surname: He fullname: He, Lei organization: Department of Spine Surgery, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510630, China – sequence: 3 givenname: Xuan surname: Wang fullname: Wang, Xuan organization: Department of Spine Surgery, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510630, China – sequence: 4 givenname: Mao surname: Pang fullname: Pang, Mao organization: Department of Spine Surgery, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510630, China – sequence: 5 givenname: Bu surname: Yang fullname: Yang, Bu organization: Department of Spine Surgery, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510630, China – sequence: 6 givenname: Feng surname: Feng fullname: Feng, Feng organization: Department of Spine Surgery, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510630, China – sequence: 7 givenname: Zizhao surname: Wu fullname: Wu, Zizhao organization: Department of Spine Surgery, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510630, China – sequence: 8 givenname: Chang surname: Liu fullname: Liu, Chang organization: Department of Spine Surgery, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510630, China – sequence: 9 givenname: Shufan surname: Zhang fullname: Zhang, Shufan organization: Department of Gynaecology, Jingchu Center Hospital Affiliated to Jingchu University of Technology, Jingmen, Hubei, 448000, China – sequence: 10 givenname: Bin orcidid: 0000-0001-9295-8176 surname: Liu fullname: Liu, Bin organization: Department of Spine Surgery, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510630, China – sequence: 11 givenname: Qiyou orcidid: 0000-0001-8817-5291 surname: Wang fullname: Wang, Qiyou email: Wqiyou@163.com organization: Department of Spine Surgery, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510630, China – sequence: 12 givenname: Limin orcidid: 0000-0002-4049-870X surname: Rong fullname: Rong, Limin email: ronglm21@163.com organization: Department of Spine Surgery, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510630, China |
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| Keywords | Mesenchymal stem cell miRNA-124-3p UCA1 miRNA-145-5p SMAD Chondrogenesis |
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| Snippet | Long noncoding RNA (lncRNAs) UCA1 has been known to be critical for the chondrogenic differentiation of marrow mesenchymal stem cells (MSCs). In this study, we... |
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| SubjectTerms | bone marrow Cell Differentiation - genetics Chondrogenesis Chondrogenesis - genetics Down-Regulation Humans Mesenchymal stem cell Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - physiology mesenchymal stromal cells MicroRNAs - metabolism miRNA-124-3p miRNA-145-5p non-coding RNA RNA, Long Noncoding - genetics SMAD Smad4 Protein - genetics Smad4 Protein - metabolism Smad5 Protein - genetics Smad5 Protein - metabolism transforming growth factor beta UCA1 |
| Title | Long noncoding RNA UCA1 promotes chondrogenic differentiation of human bone marrow mesenchymal stem cells via miRNA-145-5p/SMAD5 and miRNA-124-3p/SMAD4 axis |
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